|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Alcohol metabolites and lipopolysaccharide: Roles in the development and/or progression of alcoholic liver disease显示文摘The onset of alcoholic liver disease (ALD) is initiated by different cell types in the liver and a number of different factors including: products derived from ethanol-induced inflammation, ethanol metabolites, and the indirect reactions from those metabolites. Ethanol oxidation results in the production of metabolites that have been shown to bind and form protein adducts, and to increase inflammatory, fibrotic and cirrhotic responses. Lipopolysaccharide (LPS) has many deleterious effects and plays a significant role in a number of disease processes by increasing inflammatory cytokine release. In ALD, LPS is thought to be derived from a breakdown in the intestinal wall enabling LPS from resident gut bacterial cell walls to leak into the blood stream. The ability of adducts and LPS to independently stimulate the various cells of the liver provides for a two-hit mechanism by which various biological responses are induced and result in liver injury. Therefore, the purpose of this article is to evaluate the effects of a two-hit combination of ethanol metabolites and LPS on the cells of the liver to increase inflamma-tion and fi brosis, and play a role in the development and/or progression of ALD. | Courtney S Schaffert Michael J Duryee Carlos D Hunter Bartlett C Hamilton 3rd Amy L DeVeney Mary M Huerter Lynell W Klassen Geoffrey M Thiele | 2009 | World Journal of Gastroenterology2009，15，10： | 20 |
| 2 | Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: an analysis of the ACCORD randomised trial显示文摘 | Faramarz Ismail-Beigi Timothy Craven Mary Ann Banerji Jan Basile Jorge Calles Robert M Cohen Robert Cuddihy William C Cushman Saul Genuth Richard H Grimm Bruce P Hamilton Byron Hoogwerf Diane Karl Lois Katz Armand Krikorian Patrick O'Connor Rodica Pop-Bus | 2010 | The Lancet2010，，9739： | 2 |
| 3 | Prevalence and clinical in plications of abnormal throid hormone metabolism in advanced heart failure显示文摘 | | 1993 | Annals of Thoracic Surgery1993，56，1： | 1 |
| 4 | Inactivation of the DNA repair gene 06 - methylguanine - DNA methyl - trans- ferase by promoter hypermethylation is associated with G to A muta- tions in K - ms in colorectal tumorigenesis 显示文摘 | Esteller M Toyota M Sanchez - CM Hamilton | 2000 | Cancer Res2000，60，9： | 1 |
| 5 | Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia显示文摘 | Esteller M Hamilton SR Burger PC | 1999 | Cancer Res1999，59，4： | 1 |
| 6 | Inactivation of theDNA repair gene O6-methylguanine DNA methyltransferase bypromoter hypermethylation is a common event in primary humanneoplasia显示文摘 | Esteller M Hamilton SR Burger PC | 1999 | Cancer Res1999，59，4： | 1 |
| 7 | Altered thyroid hormone metadolism in advanced heart failure显示文摘 | Hamilton MA Sterenson LW Lun M | 1990 | JACC1990，16，： | 1 |
| 8 | An integrated anal ytical approach for determining the origin of solid bitumens in the McArthur Basin,Northern Australia显示文摘 | George S C Llorca S M Hamilton P J | 1994 | Org Geochem1994，21，： | 1 |
| 9 | Colorimetric method for determination of sugars and related substances显示文摘 | Dubois M Gilles K A Hamilton J K | 1956 | Anal Chem1956，28，： | 1 |
| 10 | Phytoremediation of soil contaminated with low concentrations of radionuclides显示文摘 | Entry J A Vance N C Hamilton M A | 1996 | Water Air Soil Pollution1996，88，： | 1 |
| 11 | Estimating the LS factor for RUSLE through iterative slope length processing of digital elevation data 显示文摘 | Van Remortel R M Hamilton and R Hickey | 2001 | Cartography2001，30，1： | 1 |
| 12 | Development of a Psychiatric Rating Scale for Primary Depression 显示文摘 | Hamilton M | 1967 | Brit Soc Clin Psychol1967，，6： | 1 |
| 13 | A sampling method for measurement of large root systems with scanner based image analysis显示文摘 | Costa C Dwyer L M Hamilton R I | 2000 | Agronomy Journal2000，92，： | 1 |
| 14 | Questioning the author 显示文摘 | Beck I McKeown M Hamilton R | 1997 | Newark DE International Reading Association1997，，5： | 1 |
| 15 | A rating scale for depression显示文摘 | Hamilton M | 1960 | J Neurol Neuro- surg Psychiatry1960，23，1： | 1 |
| 16 | Colorimetric method for determination of sugars and related substances 显示文摘 | DUBOIS M GILLES KA HAMILTON JK | 1956 | Anal Chem1956，28，3： | 1 |
| 17 | The effect of published reports of unethical conduct on stock prices显示文摘 | RAO S M HAMILTON J B | 1996 | Journal of Business Ethics1996，，12： | 1 |
| 18 | The impact of R&D intensity on demand for specialist auditor services 显示文摘 | Godfrey M Hamilton J | 2005 | Contem- porary Accounting Research2005，22，1： | 1 |
| 19 | Finding deeply-buried deposits using geochemistry显示文摘 | Cameron E M Hamilton S M Leyboume M I | 2004 | Geochemistry: Exploration Environment Analysis2004，4，1： | 1 |
| 20 | Relationships between longissimus glycolytic potential and swine growth performance,carcass traits,and pork quality显示文摘 | Hamilton D N Miller K D Ellis M | 2003 | J Anim Sci2003，81，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员