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| 1 | Alcohol metabolites and lipopolysaccharide: Roles in the development and/or progression of alcoholic liver disease显示文摘The onset of alcoholic liver disease (ALD) is initiated by different cell types in the liver and a number of different factors including: products derived from ethanol-induced inflammation, ethanol metabolites, and the indirect reactions from those metabolites. Ethanol oxidation results in the production of metabolites that have been shown to bind and form protein adducts, and to increase inflammatory, fibrotic and cirrhotic responses. Lipopolysaccharide (LPS) has many deleterious effects and plays a significant role in a number of disease processes by increasing inflammatory cytokine release. In ALD, LPS is thought to be derived from a breakdown in the intestinal wall enabling LPS from resident gut bacterial cell walls to leak into the blood stream. The ability of adducts and LPS to independently stimulate the various cells of the liver provides for a two-hit mechanism by which various biological responses are induced and result in liver injury. Therefore, the purpose of this article is to evaluate the effects of a two-hit combination of ethanol metabolites and LPS on the cells of the liver to increase inflamma-tion and fi brosis, and play a role in the development and/or progression of ALD. | Courtney S Schaffert Michael J Duryee Carlos D Hunter Bartlett C Hamilton 3rd Amy L DeVeney Mary M Huerter Lynell W Klassen Geoffrey M Thiele | 2009 | World Journal of Gastroenterology2009，15，10： | 20 |
| 2 | A sampling method for measurement of large root systems with scanner based image analysis显示文摘 | Costa C Dwyer L M Hamilton R I | 2000 | Agronomy Journal2000，92，： | 1 |
| 3 | First Paper:Measurementof the Oil-film Thickness between the Piston Ringsand Liner of a Small Diesel Engine显示文摘 | Hamilton G M Moore S L | 1974 | Proceedings ofthe Institution of Mechanical Engineering1974，188，1： | 1 |
| 4 | Directed evolution of ionizing radiation resistance in Escherichia coli 显示文摘 | Harris D R Pollock S V Wood E A Goiffon R J Klingele A J Cabot E L Schackwitz W Martin J Eggington J Durfee T J Middle C M Norton J E Popelars M C Li H Klugman S A Hamilton L L Bane L B Pennacchio L A Albert T J Perna N T Cox M M Battista J R | 2009 | Journal of Bacteriology2009，191，16： | 1 |
| 5 | Feline ilial fractures:a prospective study of dorsal plating and comparisonwith lateral plating显示文摘 | Langley-Hobbs S J Meeson R L Hamilton M H | 2009 | Vet Surg2009，38，： | 1 |
| 6 | Isolation and identification of volatiles and condensable material in raw beef with supercritical carbon dioxide extraction显示文摘 | KING M F HAMILTON B L MATTHEWS M A | 1993 | J Agric Food Chem1993，41，： | 1 |
| 7 | The role of computed tomography for localization of parathyroid adenomas显示文摘 | Zald P B Hamilton B E Larsen M L | 2008 | Laryngoscope2008，118，8： | 1 |
| 8 | Modelling the impact of zooplankton grazing on phytoplankton biomass during a dinoflagellate bloom in the Swan River Estuary, Western Australia 显示文摘 | Griffm S L Herzfeld M Hamilton D P | 2001 | Ecological Engineering2001，162，： | 1 |
| 9 | A simulation program for modeling an air-conditioning system显示文摘 | Hamilton J M J L Miller | 1990 | ASHRAE Transactions1990，96，1： | 1 |
| 10 | Morphology and yield response to weed pressure by corn hybrids differing in canopy architecture显示文摘 | Begna S H Hamilton R I Dwyer L M | 2001 | Eur J Agron2001，14，4： | 1 |
| 11 | Phage lambda cDNA cloning vectors for subtractive hybridization,fusion-protein synthesis and Cre-loxP automatic plasmid subcloning显示文摘 | Palazzolo M J Hamilton B A Ding D L | 1990 | Gene1990，1，： | 1 |
| 12 | Protein kinase C beta II mRNA levels decrease in the striatum and cortex of transgenic Huntington's disease mice 显示文摘 | Harris A S Denovan-Wright E M Hamilton L C | 2001 | J Psychiatry Neurosci2001，26，： | 1 |
| 13 | A sampling method form easurement of large root systems with scanner based image analysis显示文摘 | Costa C Dwy er L M Hamilton R I | 2000 | Agronomy Journal2000，92，： | 1 |
| 14 | Brain tumor database, a free relational database for collection and analysis of brain tumor patient information显示文摘 | Bergamino M Hamilton DJ Castelletti L | 2015 | Health Informatics J2015，21，1： | 1 |
| 15 | mVps34 is activated following high-resistance contractions显示文摘 | MACKENZIE M G HAMILTON D L MURRAY J T | 2009 | J Physiol2009，587，1： | 1 |
| 16 | Early, single ehlorhexidine application reduces ventilator-associated pneumonia in trauma patients显示文摘 | Grap M J Munro C L Hamilton V A | 2011 | Heart Lung2011，40，5： | 1 |
| 17 | mVps34 is activated by an acute bout of resistance exercise显示文摘 | MACKENZIE M G HAMILTON D L MURRAY J T | 2007 | Biochem Soc Trans2007，35，5： | 1 |
| 18 | Suppression of skeletal muscle lipo protein lipase activity during physical inactivity: A molecular rea- son to maintain daily low-intensity aetivity显示文摘 | BEY L HAMILTON M T | 2003 | J Physiol2003，551，2： | 1 |
| 19 | Colorimetric method for determination of sugars and related substances 显示文摘 | DUBOIS M GILLES K A HAMILTON l K | 1956 | ANAL CHEM1956，28，3： | 1 |
| 20 | Leafy reduced-stature maize for short-season environments:morphological aspects of inbred lines显示文摘 | Modarres A M Hamilton R I Dwyer L M | 1997 | Euphytica1997，96，2： | 1 |
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