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| 1 | Oxygen Atom Exchange Mechanism in Reaction of OH Radical with AsO显示文摘Oxygen atom exchange reaction mechanism in the reaction of OH radicals with AsO was investigated by means of the density functional theory (DFT) with 6 311++G( 3df,3pd ) and 6 311++G( d,p ) basis sets. The calculated results suggest that the reaction between OH and AsO should make the oxygen atoms exchange rapidly because the barrier to isomerization is significantly less than the HO-AsO bond dissociation energy. | CHI Yu-juan 1, YU Hai tao 1,2** , FU Hong gang 1,2 HUANG Xu ri 2, LI Ze sheng 2 and SUN Chia chung 21. College of Chemistry and Chemical Engineering, Heilongjiang University, Harbin 150080, P. R. China 2. State Key Laboratory of T | 2002 | Chemical Research in Chinese Universities2002，18，3： | 3 |
| 2 | RESEARCH ON SUPERPLASTICITY IN SiCp/2024Al AND SiCp/8090Al-Li COMPOSITES显示文摘The superplasticity in SiCp/Al alloy and SiCp/Al Li Composites is introduced The composites are prepared by powder metallurgy and cast methods The superplastic parameters are measured Superplastic treatment processing,secondary plastic working and the study of mirostructure are conducted. | Zhang Libin, Wang Zongren (School of Materials Science and Engineering,Harbin Institute of Technology) Hai Jintao (China Academy of Machinery Science and Technology) Sano T Murakoshi Y Takahashi M Hanada K Mechanical Engineering Laboratory,AIST,MITI,J | 2001 | Chinese Journal of Mechanical Engineering2001，14，4： | 2 |
| 3 | Biomarker-guided sequential targeted therapies to overcome therapy resistance in rapidly evolving highly aggressive mammary tumors显示文摘组合指向的治疗在由堵住治疗癌症是更有效的绕过机制或导致的合成致命性。然而,他们的临床的申请被抵抗和毒性妨碍。遇见这重要挑战,我们用 ErbB2-overexpressing/PTEN-low 开发了并且测试各种各样的指向的治疗的指导 biomarker 的顺序的应用程序的一个新奇概念,高度好攻击的乳癌作为我们的模型。惊人地,从遗传上设计的鼠标与 intratumoral 异质从病人和乳房的肿瘤在两 PTEN-low/trastuzumab-resistant 乳癌支撑了 ErbB2 和下游的小径驱动器 trastuzumab 抵抗的激活。尽管 lapatinib 开始禁止了 trastuzumab 抵抗的鼠标肿瘤,肿瘤由激活表明由量的蛋白质数组出现的网络的 PI3K/mTOR 绕过抑制。有趣地,小径也是的 mTOR 的激活在 neoadjuvant 观察了表明 lapatinib 抵抗的对待 lapatinib 的病人。Trastuzumab + lapatinib 抵抗被一个 PI3K/mTOR 双 kinase 禁止者(BEZ235 ) 的顺序的申请有效地没有重要毒性克服。然而,我们的 p-RTK 数组分析证明 BEZ235 治疗在遗传上设计的老鼠肿瘤导致了增加的 ErbB2 表示和 phosphorylation,导致 BEZ235 抵抗并且在 3-D,然而并非 2-D,文化。机械学地,我们作为 BEZ235 抵抗的新奇机制识别了 ErbB2 蛋白质稳定和激活,它被随后的治疗与 lapatinib + BEZ235 联合颠倒。显著地, biomarker 指导的指向的治疗的这个顺序的应用程序在很快发展加倍的抵抗的肿瘤改变忍受极其好攻击的肿瘤的鼠标的寿命。使用的这条根本上新奇的途径有效地在一个顺序的顺序罐头指向了治疗目标和改编在在治疗期间发展抵抗的癌症的发信号的网络。 | Ozgur Sahin Qingfei Wang Samuel W Brady Kenneth Ellis Hai Wang Chia-Chi Chang Qingling Zhang Preety Priya Rui Zhu Stephen T Wong Melissa D Landis William J Muller Francisco J Esteva Jenny Chang Dihua Yu | 2014 | Cell Research2014，24，5： | 2 |
| 4 | The molecular biology and nomenclature of the activating transcription factor/cAMP responsive element binding family of transcription factors:activating transcription factor proteins and homeostasis 显示文摘 | Hai T Hartman MG | 2001 | Gene2001，273，1： | 1 |
| 5 | Activating transcription factor 3,astress-inducible gene,suppresses ras-stimulated tumorigenesis显示文摘 | LU D WOLFGANG C D HAI T | 2006 | Biol Chem2006，281，10： | 1 |
| 6 | Angiomyolipoma of the liver: significance of CT and MR dynamic study显示文摘 | Ahmadi T hai Y Takahashi M | 1998 | Abdom Imaging1998，23，5： | 1 |
| 7 | Measurements and correlations of the physical of CO_Wheavy crude oil mixtures显示文摘 | Chung Frank T H Jones Ray A Nguyen Hai T | 1988 | SPE Reservoir Engi- neering1988，40，8： | 1 |
| 8 | Effects of nitrogen and phosphorus on blue grama growth and mycorrhizal infection 显示文摘 | Hays R Reid C C P John T V St Coleman D C | 1982 | Oecologia1982，54，： | 1 |
| 9 | Hepatocellular carcinoma arising from non-alcoholic steatohepatitis:report of two cases显示文摘 | Hai S Kubo S Shuto T | 2006 | Surg Today2006，36，4： | 1 |
| 10 | Two-channel direction-detection Doppler lidar employing a charge -coupled device as a detector显示文摘 | IRGANG T D HAYS P B SKINNER W R | 2002 | Appl Opt2002，41，6： | 1 |
| 11 | A systematic review of the role of hydrolyzed infant formulas in allergy prevention显示文摘 | Hays T Wood RA | 2005 | Arch Pediatr Adolesc Med2005，159，9： | 1 |
| 12 | Artemisinin pharmacokinetics and efficacy in uncomplicated-malaria patients treated with two different dosage regimens显示文摘 | Gordi T Huong D X Hai T N | | 0，，04： | 1 |
| 13 | Developing process for coating copper particles with silver by electroless plating method 显示文摘 | HAI H T AHN J Q KIM D J | 2006 | Surf Coat Technol2006，201，6： | 1 |
| 14 | FLT3 receptors with intenal Tandem dup lications promote cell viability and proliferation by signaling through Foxo proteins显示文摘 | Blanea Scheijen Hai T Ngo Hyun Kang | 2004 | J Oncogene2004，23，19： | 1 |
| 15 | Noise-limited performance of spectral-amplitude-coding optical CDMA in fiber-optic radio highway networks显示文摘 | Emeec hai T D | 2005 | IEE Procoptoelecyron2005，152，5： | 1 |
| 16 | Sex attractants for moths of Vietnam: Field attraction by synthetic lures baited with known lep- idopteran pheromones 显示文摘 | Hai T V Vang L V Son P K | 2002 | J Chem Ecol2002，28，： | 1 |
| 17 | The cost of crime to society: New crime-specific estimates for policy and program evaluation显示文摘 | Kathryn E Mccollister Michael T French Hai Fang | 2010 | Drug and Alcohol Dependence2010，108，1： | 1 |
| 18 | Development in high-performance liquid chromatography for high-throughput profiling and metabonomic studies of biofluid samples 显示文摘 | Kaskavelis Hai P T Daykin L Janssen C A | 2003 | J Chromatogr B2003，789，： | 1 |
| 19 | Metal matrix composites in China显示文摘 | Zhang L B Hai J T | 1998 | Materials Processing Technology1998，75，： | 1 |
| 20 | The preparation of nano-sized HZSM-5 zeolite and its application in the aromatization of methanol显示文摘 | NI Y-M SUN A-M WU X-L HAI G-L HU J-L LI T LI G-X | 2011 | Microporous Mesoporous Mater2011，143，23： | 1 |
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