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| 1 | Serelaxin increases the antifibrotic action of rosiglitazone in a model of hepatic fibrosis显示文摘AIM To determine the effect of combined serelaxin and rosiglitazone treatment on established hepatic fibrosis.METHODS Hepatic fibrosis was induced in mice by carbon tetrachloride administration for 6 wk, or vehicle alone(nonfibrotic mice). For the final 2 wk, mice were treated with rosiglitazone, serelaxin, or both rosiglitazone and serelaxin. Serum liver enzymes and relaxin levels were determined by standard methods. The degree of liver collagen content was determined by histology and immunohistochemistry. Expression of type?Ⅰ?collagen was determined by quantitative PCR. Activation of hepatic stellate cells was assessed by alpha-smoothmuscle actin(SMA) levels. Liver peroxisome proliferator activated receptor-gamma coactivator 1 alpha(PGC1α) was determined by Western blotting.RESULTS Treatment of mice with CCl4 resulted in hepatic fibrosis as evidenced by increased liver enzyme levels(ALT and AST), and increased liver collagen and SMA. Monotherapy with either serelaxin or rosiglitazone for 2 wk was generally without effect. In contrast, the combination of serelaxin and rosiglitazone resulted in significantly improved ALT levels(P < 0.05). Total liver collagen content as determined by Sirius red staining revealed that only combination treatment was effective in reducing total liver collagen(P < 0.05). These results were supported by immunohistochemistry for type?Ⅰ?collagen, in which only combination treatment reduced fibrillar collagen levels(P < 0.05). The level of hepatic stellate cell activation was modestly, but significantly, reduced by serelaxin treatment alone, but combination treatment resulted in significantly lower SMA levels. Finally, while hepatic fibrosis reduced liver PGC1α levels, the combination of serelaxin and rosiglitazone resulted in restoration of PGC1α protein levels.CONCLUSION The combination of serelaxin and rosiglitazone treatment for 2 wk was effective in significantly reducing established hepatic fibrosis, providing a potential new treatment strategy. | Robert G Bennett Ronda L Simpson Frederick G Hamel | 2017 | World Journal of Gastroenterology2017，23，22： | 2 |
| 2 | Collaborate with your customers and win显示文摘 | Hamel G Doz Y L Prahalad C K | 1989 | Harvard Business Review1989，，61： | 1 |
| 3 | Health care co- sts and mortality associated with nosocomial diarrheadue to Clostridium difficile显示文摘 | Kyne L Hamel MB Polavaram R | 2002 | Clin Infect Dis2002，34，3： | 1 |
| 4 | YKL-40,a secreted glycoprotein, promotes tumorangiogenesis 显示文摘 | Shao R Hamel K Petersen L | 2009 | Oncogene2009，28，50： | 1 |
| 5 | Endoglin expression on human microvascular endothelial cells association with betaglycan and formation of higher order complexes with TGF-beta signaling receptors显示文摘 | Wong S H Hamel L Chevalier S | 2000 | Eur J Biochem2000，267，17： | 1 |
| 6 | NH3, N2O and CH4 emissions during passively aerated composting of straw-rich pig manure显示文摘 | Szanto G L Hamelers H M Rulkens W H | 2007 | Bioresource Technology2007，98，14： | 1 |
| 7 | Carboplatin nanocapsules:a highly cytoloxic, phospholipid- based formulation of carboplatin 显示文摘 | HAMELERS I H L LOENEN E V STAFFttORST R W H M | 2006 | Mol Carlcer Ther2006，5，8： | 1 |
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| 10 | The quest for resilience显示文摘 | Hamel G Valikangas L | | 0，，09： | 1 |
| 11 | Ancient signals: comparative genomics of plant MAPK and MAPKK gene families 显示文摘 | Hamel L P Nicole M C Sritubtim S | 2006 | Trends Plant Sci2006，11，4： | 1 |
| 12 | Angioimmunoblastic lymphadenopathy followingciprofloxacin administration显示文摘 | Knoops L van den Neste E Hamels J | 2002 | Acta Clin Belg2002，57，2： | 1 |
| 13 | Benign and Malignant Phyllodes Tumors, Mammographic and Sonographic Findings 显示文摘 | Liberman L Bonaccio E Hamele - Benal D | 1996 | Radiology1996，198，1： | 1 |
| 14 | Collaborate with your competitors and win 显示文摘 | HAMEL G D WVES L PRAHALAD C K | 1989 | Harvard Business Review1989，，12： | 1 |
| 15 | YKL-40, a secreted glycoprotein, promotes tumor angiogenesis 显示文摘 | Shao R_ Hamel K Petersen L et o1 | 2009 | Oncogene2009，28，50： | 1 |
| 16 | Comparison between different strategies of covalent attachment of DNA to glass surfaces to build DNA microarrays显示文摘 | ZAMMATTEO N JEANMART L HAMELS S | 2000 | Anal Chem2000，280，1： | 1 |
| 17 | Detection and characterization of Porcine circovirus associated with postweaning multisystemic wasting syndrome in Pigs显示文摘 | Nayar GPS Hamel A Lin L | 1997 | Can Vet J1997，38，： | 1 |
| 18 | Nucleotide sequence of the porcine circovirus associated with postweaning multisystemic was- ting syndrome in pigs显示文摘 | Hamel A L Lin L L Nayar G P | 1998 | J Virol1998，72，： | 1 |
| 19 | Characterization of endoglin on mouse uterine stromal cells显示文摘 | Ouellette MJ Hamel L Tremblay N | 1999 | Reprod Fertil1999，117，2： | 1 |
| 20 | A review: the anaerobic treatment of sewage in UASB and EGSB reactors 显示文摘 | Seghezzo L Zeeman G van IAer J B Hamelers H V M Lettinga G | 1998 | Bioresource Technology1998，65，3： | 1 |
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