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| 1 | Role of E3 ubiquitin ligases in lung cancer显示文摘E3 ubiquitin ligases are a large family of proteins that catalyze the ubiquitination of many protein substrates for targeted degradation by the 26S proteasome.Therefore,E3 ubiquitin ligases play an essential role in a variety of biological processes including cell cycle regulation,proliferation and apoptosis.E3 ubiquitin ligases are often found overexpressed in human cancers,including lung cancer,and their deregulation has been shown to contribute to cancer development.However,the lack of specific inhibitors in clinical trials is a major issue in targeting E3 ubiquitin ligases with currently only one E3 ubiquitin ligase inhibitor being tested in the clinical setting.In this review,we focus on E3 ubiquitin ligases that have been found deregulated in lung cancer.Furthermore,we discuss the processes in which they are involved and evaluate them as potential anti-cancer targets.By better understanding the mechanisms by which E3 ubiquitin ligases regulate biological processes and their exact role in carcinogenesis,we can improve the development of specific E3 ubiquitin ligase inhibitors and pave the way for novel treatment strategies for cancer patients. | Barbara C Snoek Leonie HAM de Wilt Gerrit Jansen Godefridus J Peters | 2013 | World Journal of Clinical Oncology2013，4，3： | 5 |
| 2 | Prevalence,Capsular Type and Antimicrobial Susceptibility of Streptococcus suis Isolated from Slaughter Pigs in Korea显示文摘 | Han D U Choi C Ham H J | 2001 | Can J Vet Res2001，65，3： | 1 |
| 3 | Human interferon-λ3 is a potent member of the type III interferon family 显示文摘 | Dellgren C Gad HH Hamming OJ | 2009 | Genes Im- mun2009，10，2： | 1 |
| 4 | Antihypertensivc therapy upregulates renin and (pro) renin receptor in the clipped kidney of Gold blatt hypertensive rats显示文摘 | Krebs C Hamming I Sadaghiani S | | 0，，06： | 1 |
| 5 | Visual scanpath dysfunction in first-degree relatives of schizophrenia probands: evidence for a vulnerability marker? 显示文摘 | Loughland C M Williams L M Hams A W | 2004 | Schizophr Res2004，67，1： | 1 |
| 6 | Feasibility of a constructed wetland and wastewater stabilisation pond system as a sewage reclamation system for agricultural reuse in a decentralised rural area 显示文摘 | Ham J H Yoon C G Jeon J H | 2007 | Water Science & Technology2007，55，12： | 1 |
| 7 | Authenticated group key transfer protocol based on secret sharing显示文摘 | Ham L Lin C | 2010 | IEEE Transactions on Computers2010，59，6： | 1 |
| 8 | Gastric emptying with gastro-oesophageal reflux显示文摘 | Di Lorenzo C Piepsz A Ham H | 1987 | Arch Dis Child1987，62，5： | 1 |
| 9 | Association of a 76 kDa polypeptide with soluble starch synthase I activity in maize (cv B73) endosperm 显示文摘 | Mu C Ham C Ko Y T | 1994 | The Plant Journal1994，6，2： | 1 |
| 10 | An Analysis of Addition and Subtraction Word Problems in American and Soviet Elementary Mathematics Textbooks 显示文摘 | Stigler J W Fuson K C Ham M | 1986 | Cognition and Instruction1986，，3： | 1 |
| 11 | Polymorphism of the beta (2)-adrenoceptor in COPD in Chinese subjects 显示文摘 | Ho L I Ham H J Chen C J | 2001 | Chest2001，120，5： | 1 |
| 12 | Comparative effects of plasma apheresis and intravenous cyclophosphamide on urinary pedocyte excretion in patients with proliferative lupus nephritis显示文摘 | Nakamura T Ushiyama C Ham M | 2002 | Clin Nephrol2002，57，2： | 1 |
| 13 | Spatial separation of HLADM/HLA-DR interactions within MIIC and phagosome-induced immune escape显示文摘 | Zwart W Griekspoor A Kuijl C Marsman M van Rheenen J Janssen H Calafat J van Ham M Janssen L van Lith M Jalink K Neefjes J | 2005 | Immunity2005，22，： | 1 |
| 14 | A Statistical analysis of the Los Angeles ambient carbon monoxide data 1955-1972 显示文摘 | Tiao G C Box G E P Hamming W J | 1975 | J Air Pollut Control Assoc1975，24，： | 1 |
| 15 | Interferon-lambda is functionally an interferon but structurally related to the interleukin-10 family显示文摘 | Gad HH Dellgren C Hamming OJ | 2009 | J Biol Chem2009，284，20： | 1 |
| 16 | Some higher-order modications of Newton's method for solving nonlinear equations显示文摘 | Ham Y Chun C Lee S G | 2008 | Journal of Computational and Applied Mathematics2008，222，： | 1 |
| 17 | Interference minimized multi-path routing with congestion control in wireless sensor networks for high-rate streaming显示文摘 | Teo J Y Ha Y J Ham C K | 2008 | IEEE Transactions on Mobile Computing2008，7，9： | 1 |
| 18 | Phased-array wavelength demultiplexer with flattened wavelength re-sponse 显示文摘 | Amersfoort M R de Boer C R van Ham F P G | 1994 | Electron Lett1994，30，4： | 1 |
| 19 | Phased-array wavelength demultiplexer with flattened wavelength response显示文摘 | Amersfoort M R Boer C R Ham F P G | 1994 | Electron Lett1994，30，4： | 1 |
| 20 | Observability, eigenvalues and Kalman filtering显示文摘 | HAM F M BROWN R C | 1983 | IEEE Trans AES1983，19，2： | 1 |
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