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| 1 | Methodology to develop machine learning algorithms to improve performance in gastrointestinal endoscopy显示文摘Assisted diagnosis using artificial intelligence has been a holy grail in medical research for many years, and recent developments in computer hardware have enabled the narrower area of machine learning to equip clinicians with potentially useful tools for computer assisted diagnosis(CAD) systems. However, training and assessing a computer's ability to diagnose like a human are complex tasks, and successful outcomes depend on various factors. We have focused our work on gastrointestinal(GI) endoscopy because it is a cornerstone for diagnosis and treatment of diseases of the GI tract. About 2.8 million luminal GI(esophageal, stomach, colorectal) cancers are detected globally every year, and although substantial technical improvements in endoscopes have been made over the last 10-15 years, a major limitation of endoscopic examinations remains operator variation. This translates into a substantial inter-observer variation in the detection and assessment of mucosal lesions, causing among other things an average polyp miss-rate of 20% in the colon and thus the subsequent development of a number of post-colonoscopy colorectal cancers. CAD systems might eliminate this variation and lead to more accurate diagnoses. In this editorial, we point out some of the current challenges in the development of efficient computer-based digital assistants. We give examples of proposed tools using various techniques, identify current challenges, and give suggestions for the development and assessment of future CAD systems. | Thomas de Lange Pal Halvorsen Michael Riegler | 2018 | World Journal of Gastroenterology2018，24，45： | 6 |
| 2 | Professionalism Reconsidered Priorities for Physicians显示文摘 | Halvorsen J G | 1999 | Arch FamMed1999，8，： | 1 |
| 3 | The prevalence of CMA/CMPI in young children: the prevalence of allergy to egg :a population based study in young children 显示文摘 | Eggesbo M Botten G Halvorsen R | 2001 | Allergy2001，56，5： | 1 |
| 4 | Atherosclerotic Plaque Stability—What Determines the Fate of a Plaque?显示文摘 | Bente Halvorsen Kari Otterdal Tuva B. Dahl Mona Skjelland Lars Gullestad Erik ?ie P?l Aukrust | 2008 | Progress in Cardiovascular Diseases2008，，3： | 1 |
| 5 | Metacognitions and thought control strategies in unipo- lar major depression: A comparison of currently depressed, previ- ously depressed, and never - depressed individuals 显示文摘 | MARIANNE HALVORSEN ROGER HAGEN ODIN HJEM- DAL | 2015 | Cognitive Therapy and Research2015，59，1： | 1 |
| 6 | Telomerase activity is sufficient to allow transformed cells to escape from crisis显示文摘 | HALVORSEN T L LEIBOWITZ G LEVINE F | 1999 | Mol Cell Biol1999，19，： | 1 |
| 7 | Influence of mucinous component survival in colorectal adenocarcinoma:a multivariate analysis显示文摘 | Halvorsen T Seim E | 1988 | J ClinPathol1988，41，10： | 1 |
| 8 | ERG upregu-lation and related ETS transcription factors in prostate cancer 显示文摘 | Rostad K Mannelqvist M Halvorsen OJ | 2007 | Int J Oncol2007，30，1： | 1 |
| 9 | Measurements of vertical displacement in running,a methodological comparison显示文摘 | Gullstrand L Halvorsen K Tinmark F | 2009 | Gait Posture2009，30，1： | 1 |
| 10 | Grain and cellulosicethanol:history,economics,and energy policy显示文摘 | Solomon B Barnes J Halvorsen K | 2007 | Bi-omass and Bioenergy2007，31，6： | 1 |
| 11 | Extracellular matrix mineralization and osteoblast gene expression by human adipose tissue-derived stromal cells 显示文摘 | Halvorsen YD Franklin D Bond AL | 2001 | Tissue Eng2001，7，： | 1 |
| 12 | EZH2 Expression Is Associated With High Proliferation Rate and Aggressive Tumor Subgroups in Cutaneous Melanoma and Cancers of the Endometri- um, Prostate, and Breast 显示文摘 | Bachmann 1 M Halvorsen O J Collett K | 2006 | Journal of Clinical Oncology2006，24，2： | 1 |
| 13 | A systematic screening of total antioxidants in dietary plants 显示文摘 | Halvorsen B L Holte K Myhrstad M C W | 2002 | Journal of Nutrition2002，132，3： | 1 |
| 14 | Pharmacokinetic comparison of acetaminophen elixir versus suppositories in vaccinatedinfants (aged 3 to 36 months) : a single-dose, open- label, randomized, parallel-group design 显示文摘 | Walson PD Halvorsen M Edge J | 2013 | Clin Ther2013，35，2： | 1 |
| 15 | The peripheral blood mononuclear cell microRNA signature of coronary artery disease显示文摘 | Hoekstra M van der Lans CA Halvorsen B | 2010 | Biochem Biophys Res Commun2010，394，3： | 1 |
| 16 | Grain and cellulosic ethanol: History, economics and energy policy显示文摘 | Solomon B D Bames J R Halvorsen K E | 2007 | Biomass and Bioenergy2007，31，6： | 1 |
| 17 | Gastric adenocinoma; CT versus surgical staging显示文摘 | Sussman SK Halvorsen RA Jr Illescas FF | 1988 | Radiology1988，167，： | 1 |
| 18 | Chemokines and cardiovascular risk 显示文摘 | Aukrust P Halvorsen B Yndestad A | 2008 | Arterioscler Thromb Vasc Biol2008，28，11： | 1 |
| 19 | Content of redox- active compounds (ie,'antioxidants) in foods consumed in the United States显示文摘 | Halvorsen L Carlsen H Phillips M | 2006 | Am J Clin Nutr2006，84，1： | 1 |
| 20 | Cadmium blocks receptor-media- ted Jak/STAT signaling in neurons by oxidative stress显示文摘 | Monroe R K Halvorsen S W | 2006 | Free Radical Biology and Medicine2006，41，3： | 1 |
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