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| 1 | Final efficacy analysis, interim safety analysis, and immunogenicity of a single dose of recombinant novel coronavirus vaccine (adenovirus type 5 vector) in adults 18 years and older: an international, multicentre, randomised, double-blinded, placebo-controlled phase 3 trial显示文摘Background:The Ad5-nCoV vaccine is a single-dose adenovirus type 5(Ad5)vectored vaccine expressing the SARS-CoV2 spike protein that was well-tolerated and immunogenic in phase 1 and 2 studies.In this study,we report results on the final efficacy and interim safety analyses of the phase 3 trial.Methods:This double-blind,randomised,international,placebo-controlled,endpoint-case driven,phase 3,clinical trial enrolled adults aged 18 years older at study centres in Argentina,Chile,Mexico,Pakistan,and Russia.Participants were eligible for the study if they had no unstable or severe underlying medical or psychiatric conditions;had no history of a laboratoryconfirmed SARS-CoV-2 infection;were not pregnant or breastfeeding;and had no previous receipt of an adenovirus-vectored,coronavirus,or SARS-CoV-2 vaccine.After informed consent was obtained,25 mL of whole blood was withdrawn from all eligible participants who were randomised in a 1:1 ratio to receive a single intramuscular dose of 0·5 mL placebo or a 0·5 mL dose of 5×1010 viral particle(vp)/mL Ad5-nCoV vaccine;study staff and participants were blinded to treatment allocation.All participants were contacted weekly by email,telephone,or text message to self-report any symptoms of COVID-19 illness,and laboratory testing for SARS-CoV-2 was done for all participants with any symptoms.The primary efficacy objective evaluated Ad5-nCoV in preventing symptomatic,PCR-confirmed COVID-19 infection occurring at least 28 days after vaccination in all participants who were at least 28 days postvaccination on Jan 15,2021.The primary safety objective evaluated the incidence of any serious adverse events or medically attended adverse events postvaccination in all participants who received a study injection.This trial is closed for enrolment and is registered with ClinicalTrials.gov(NCT04526990). | Scott A Halperin | 2021 | 四川生理科学杂志2021，43，10： | 2 |
| 2 | Cold and hot denaturation ofpolysoaps显示文摘 | Leckband D E Borisov 0 V Halperin A | 1998 | Macromolecules1998，31，7： | 1 |
| 3 | Membrane signa- ling by complement C5b-9,the membrane attack complex显示文摘 | NICHOI-SON-WELLER A HALPERIN J A | 1993 | Immunol Res1993，12，3： | 1 |
| 4 | Expression of alpha v and beta 3 integrin subunits in rat osteoclasts in sizu显示文摘 | Shinar DM Schmidt A Halperin D | 1993 | J Bone Miner Res1993，8，4： | 1 |
| 5 | Long-term follow-up (5-20 year) after uterine ventrosuspension for chronic pelvic pain and deep dyspareunia 显示文摘 | Halperin R Padoa A Schneider D | 2003 | Gynecol Obstet Invest2003，55，4： | 1 |
| 6 | The effect of surface regular microtopography on fretting fatigue life显示文摘 | Volchok A Halperin G Etsion I | | 0，，3： | 1 |
| 7 | Risk of thromboembolism in heart failure-analysis from the sudden cardiac death in heart failure trial (SCD-HeFT)显示文摘 | Freudenberger R S Hellkamp A S Halperin J L | 2007 | Circulation2007，115，20： | 1 |
| 8 | Sternal force-displacement relationship during cardiopulmonary resuscitation显示文摘 | GRUBEN K G GUERCI A D HALPERIN H R | 1993 | J Biomech Eng1993，115，2： | 1 |
| 9 | Canine sternal force-displacement relationship during cardiopulmonary resuacitation显示文摘 | GRUBEN K G HALPERIN H R POPEL A S | 1999 | IEEE Trans Biomed Eng1999，46，7： | 1 |
| 10 | Complications of circumcision in male neonates, infants and children: a systematic review显示文摘 | Weiss H A Larke N Halperin D | 2010 | BMC Urol2010，10，2： | 1 |
| 11 | Safety and immunogenicity of a trivalent,inactivated,mammalian cell culture-derived influenza vaccine in healthy adults,seniors,and children显示文摘 | Halperin S A Smith B Mabrouk T | 2002 | Vaccine2002，20，： | 1 |
| 12 | Abraham Flexner of Ken tucky, His Report, Medical Education in the United States and Can ada and the Historical Questions Raised by the Report显示文摘 | Halperin E C Perman J A Wilson E A | 2010 | Aca demic Medicine2010，85，： | 1 |
| 13 | Dronedarone in high-risk permanent atrial fibrillation 显示文摘 | Connolly SJ Carom A J Halperin JL | 2011 | N Engl J Med2011，365，24： | 1 |
| 14 | Use of Chinese overy cell cytotoxicity assay for the rapid diagnosis of pertussis显示文摘 | Halperin SA Bortolussi R Kasina A | 1990 | J Clin Microbiol1990，28，1： | 1 |
| 15 | Anger, Hatred and the Quest for Peace:Anger can be Constructive in Absence of Hatred 显示文摘 | HALPERIN E RUSSELL G A DWECK S C | 2011 | Journal of Conflict Resolution2011，55，2： | 1 |
| 16 | Tethered chains in polymer microstructures 显示文摘 | Halperin A Tirrell M Lodge T P | 1992 | Adv Polym Sco1992，100，： | 1 |
| 17 | Optical studies in X-irradiated high purity sodium silicate glasses显示文摘 | Mackey J H Smith H L Halperin A | 1966 | J Phys Chem Solids1966，27，： | 1 |
| 18 | Safety and immu- nogenicity of a trivalent, inactivated, mammalian cell culture de- rived influenza vaccine in healthy adults, seniors, and children 显示文摘 | HALPERIN S A SMITH B MABROUK T | 2002 | Vaccine2002，20，78： | 1 |
| 19 | Complications of circumcision in male neonates, infants and children: a sys- tematic review显示文摘 | Weiss H A Larke N Halperin D | 2010 | BMC urology2010，10，1： | 1 |
| 20 | The effect of surface regular microtopography on fretting fatigue life显示文摘 | G Halperin I Halperin | 2002 | Wear2002，253，： | 1 |
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