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| 1 | AZF microdeletions and partial deletions of AZFc region on the Y chromosome in Moroccan men显示文摘瞄准:第一次评估 Y 染色体的频率,并且讨论 AZF 删除的临床的意义微删除和在摩洛哥的人的 AZFc 区域的部分删除的出现。方法:我们屏蔽了 Y 染色体微删除和不肥沃的人的一个连续的组的 AZFc 区域的部分删除(n = 149 ) 并且控制(100 个肥沃的人, 76 个 normospermic 人) 。AZFa, AZFb, AZFc 和 AZFc 区域的部分删除被聚合酶链反应(PCR ) 根据确定的协议分析。结果:在为微删除屏蔽的 127 个不肥沃的人之中,四个题目被发现有微删除:二 AZFc 删除和二 AZFb+AZFc 删除。所有删除仅仅在 azoospermic 题目被发现(4/48, 8.33%) 。全面 AZFc 删除频率是低的(4/127, 3.15%) 。AZF 微删除没在 oligoasthenoteratozoospermia (燕麦) 或控制被观察。AZFc (gr/gr ) 的部分删除总共部分 AZFc 删除(gr/gr ) 在控制组被发现的 149 个不肥沃的人(4.70%) 中的 7 个和 7 的被观察(7/176, 3.98%) 。另外,二 b2/b3 删除在二个 azoospermic 题目被识别(2/149, 1.34%) 然而并非在控制组。结论:我们的结果建议 Y 染色体 AZF 微删除的频率与严重 spermatogenic 失败在个人被提高并且 gr/gr 删除没与 spermatogenic 失败被联系。 | Laila Imken Brahim El Houate Abdelaziz Chafik Halima Nahili Redouane Boulouiz Omar Abidi Elbakkay Chadli Noureddine Louanjli Abdelouhab Elfath Mohammed Hassar Ken McElreavey Abdelhamid Barakat Hassan Rouba | 2007 | Asian Journal of Andrology2007，9，5： | 22 |
| 2 | Emotion processing in Parkinson's disease: a blood oxygenation level-dependent functional magnetic resonance imaging study显示文摘Parkinson's disease is a neurodegenerative disorder caused by loss of dopamine neurons in the substantia nigra pars compacta. Tremor, rigidity, and bradykinesia are the major symptoms of the disease. These motor impairments are often accompanied by affective and emotional dysfunctions which have been largely studied over the last decade. The aim of this study was to investigate emotional processing organization in the brain of patients with Parkinson's disease and to explore whether there are differences between recognition of different types of emotions in Parkinson's disease. We examined 18 patients with Parkinson's disease(8 men, 10 women) with no history of neurological or psychiatric comorbidities. All these patients underwent identical brain blood oxygenation level-dependent functional magnetic resonance imaging for emotion evaluation. Blood oxygenation level-dependent functional magnetic resonance imaging results revealed that the occipito-temporal cortices, insula, orbitofrontal cortex, basal ganglia, and parietal cortex which are involved in emotion processing, were activated during the functional control. Additionally, positive emotions activate larger volumes of the same anatomical entities than neutral and negative emotions. Results also revealed that Parkinson's disease associated with emotional disorders are increasingly recognized as disabling as classic motor symptoms. These findings help clinical physicians to recognize the emotional dysfunction of patients with Parkinson's disease. | Mohammed Benzagmout Sa?d Boujraf Badreeddine Alami Hassane Ali Amadou Halima El Hamdaoui Amine Bennani Mounir Jaafari Ismail Rammouz Mustapha Maaroufi Rabia Magoul Driss Boussaoud | 2019 | Neural Regeneration Research2019，14，4： | 6 |
| 3 | Sclareol and linalyl acetate are produced by glandular trichomes through the MEP pathway显示文摘Sclareol,an antifungal specialized metabolite produced by clary sage,Salvia sclarea,is the starting plant natural molecule used for the hemisynthesis of the perfume ingredient ambroxide.Sclareol is mainly produced in clary sage flower calyces;however,the cellular localization of the sclareol biosynthesis remains unknown.To elucidate the site of sclareol biosynthesis,we analyzed its spatial distribution in the clary sage calyx epidermis using laser desorption/ionization mass spectrometry imaging(LDI–FTICR-MSI)and investigated the expression profile of sclareol biosynthesis genes in isolated glandular trichomes(GTs).We showed that sclareol specifically accumulates in GTs’gland cells in which sclareol biosynthesis genes are strongly expressed.We next isolated a glabrous beardless mutant and demonstrate that more than 90%of the sclareol is produced by the large capitate GTs.Feeding experiments,using 1-13 C-glucose,and specific enzyme inhibitors further revealed that the methylerythritol-phosphate(MEP)biosynthetic pathway is the main source of isopentenyl diphosphate(IPP)precursor used for the biosynthesis of sclareol.Our findings demonstrate that sclareol is an MEP-derived diterpene produced by large capitate GTs in clary sage emphasing the role of GTs as biofactories dedicated to the production of specialized metabolites. | Camille Chalvin Stephanie Drevensek Françoise Gilard Caroline Mauve Christel Chollet Halima Morin Edith Nicol Eva Heripre Lucie Kriegshauser Bertrand Gakiere Michel Dron Abdelhafid Bendahmane Adnane Boualem | 2021 | Horticulture Research2021，8，1： | 2 |
| 4 | Dietary betaine activates hepatic VTGⅡexpression in laying hens associated with hypomethylation of GR gene promoter and enhanced GR expression显示文摘Background: Vitellogenin(VTG) is a precursor of egg yolk proteins synthesized within the liver of oviparous vertebrates. Betaine is an important methyl donor that is reported to improve egg production of laying hens with an unclear mechanism. In the present study, we fed betaine-supplemented diet(0.5%) to laying hens for 4 wk and investigated its effect on VTGII expression in the liver.Results: Betaine did not affect chicken weight, but significantly(P < 0.05) increased egg laying rate accompanied with a significant(P < 0.05) increase in hepatic concentration and plasma level of VTGI. Plasma estrogen level did not change,but the hepatic expression of estrogen receptor α(ERα) mR NA was significantly(P < 0.05) up-regulated. Betaine did not affect the protein content of ERα, but significantly(P < 0.05) increased hepatic expression of glucocorticoid receptor(GR)at both mR NA and protein levels. Also, ERα/GR interaction tended to be enhanced in the liver nuclear lysates of betainesupplemented hens as determined by co-immunoprecipitation. Furthermore, dietary betaine supplementation significantly increased(P < 0.05) the hepatic expression of methyl-transfer enzymes, such as BHMT, GNMT, and DNMT1,which was associated with higher SAM/SAH ratio and hypomethylation of GR promoter regions.Conclusions: Betaine activates hepatic VTGII expression in association with modified DNA methylation of GR gene promoter, GR expression and ERα/GR interaction. Activation of hepatic VTGII expression may contribute, at least partly, to improved egg production in betaine-supplemented hens. | Nagmeldin A.Omer Yun Hu Yan Hu Abdulrahman A.Idriss Halima Abobaker Zhen Hou Haibo Dong Ruqian Zhao | 2018 | Journal of Animal Science and Biotechnology2018，9，2： | 2 |
| 5 | Preservation of Juniperus thurifera L.:a rare endangered species in Algeria through in vitro regeneration显示文摘Juniperus thurifera L.is an endemic Cupres saceae from the Aure`s Mountains of north eastern Algeria and endangered,in part,due to the scarcity of viable seeds It is threatened by other abiotic factors and the lack of an effective management strategy will increase its risk o extinction.The dearth of information on its in vitro regeneration impedes its application in forest managemen programs.We therefore developed a micropropagation protocol using microcuttings with auxiliary buds.Cuttings were grown on different combinations of media supplemented with plant growth regulators at different concentrations.The highest number of shoots and branches regenerated from original shoots was obtained on Woody Plant Medium(WPM)supplemented with 6-benzylaminopurine(BAP)(0.5 mg L^(-1))and 2,4-dichlorophe noxyacetic acid(2,4-D)(0.25 mg L^(-1)).The best elongation of shoots was achieved with WPM supplemented with0.5 mg L^(-1)of BAP and 0.25 or 1 mg L^(-1) of 2,4-D.On the second subculture,shoots had a higher number of branches than those of the first.The highest rooting rate,38.8%,was obtained with shoots cultured in 1/2 Murashige and Skoog(MS)medium supplemented with 5.0 mg L^(-1)each of indol-3-butyric(IBA)and naphthalene acetic acid(NAA).Similarly,the highest root numbers and lengths were produced on 1/2 MS medium supplemented with IBA and NAA(5.0 mg L^(-1)each).During transfer to acclimatization,rates of plant losses of 50% occurred.The second part of the experiment showed that the best shoot callusing was on WPM supplemented with BAP and 2,4-D,with either the combination 0.5+0.25 or 0.25+0.25 mg L^(-1).The results of this research provide a starting point for further studies on in vitro regeneration of J.thurifera for the sustainable management of its unique ecosystem in the Mediterranean basin. | Nadia Khater Halima Benbouza | 2019 | Journal of Forestry Research2019，30，1： | 2 |
| 6 | Optimization of a reliable, fast, cheap and sensitive silver staining method to detect SSR markers in poly- aerylarnide gels显示文摘 | Halima B Jacquemin J M Baudoin J P | 2006 | Biotechnology Agronomy Society and Environment2006，10，2： | 1 |
| 7 | Prognostic value of high-sensitivity C-reactive protein in assessing intrahospital outcome of unstable angina显示文摘 | Kammoun I | 2003 | Tunis Med2003，81，8： | 1 |
| 8 | GABAergic neurosteroids: The “endogenous benzodiazepines” of acute liver failure显示文摘 | Samir Ahboucha Halima Gamrani Glen Baker | 2011 | Neurochemistry International2011，，7： | 1 |
| 9 | Pre-clinical models of human cerebral small vessel disease: Utility for clinical application显示文摘 | Atticus H H John F B Halima K | 2012 | Journal of Neurological Sciences2012，322，12： | 1 |
| 10 | Comparison study of ammonia and COD adsorption on zeolite,activated carbon and composite materials in landfill leachate treatment显示文摘 | Azhar A Halima Hamidi A Azizb Megat Azmi Megat Joharib | 2010 | Desalination2010，17，2： | 1 |
| 11 | A comparative study between parabolic trough collector and linear Fresnel reflector technologies显示文摘 | Najla E1 Gharbi Halima Derbal Sofiane Bouaichaoui Noureddine Said | 2011 | Ener gy Procedia2011，，6： | 1 |
| 12 | Inhaled cor- ticosteroids in idiopathic pulmonary hemosiderosis: 2 cas- escortieosteroids 显示文摘 | Ben Halima N Karray A Krichen A | 2003 | Tunis M ed2003，81，4： | 1 |
| 13 | Functional properties of peptides obtained from whey proteins by ficin extract hydrolysis显示文摘Enzymatic whey proteins concentrates (WPC) hydrolysis under optimal conditions of ficin crude extract (FCE) in two ratios E/S (0.5 and 1%) was studied,assessing the impact of hydrolysis on WPC by determination degree of hydrolysis (DH),Fast proteins liquid chromatography (FPLC),Tricine SDS-PAGE,antioxidant activity at sampling time beside,and technological properties (solubility,emulsifying activity index (EAI) and foaming activity (FA)) at the best condition (maximum DH and antioxidant activity) other side.Results showed,in the first 30 min,DH reached 22.76% at E/S (1%) with a total degradation of α-lactalbumin (α-La) and almost of β-lactoglobulin (β-Lg).A significant increase in antioxidant activity and solubility was observed,while not for EAI,and FA.These results indicate for the first time that β-Lg is susceptible to hydrolyse by FCE that rarely found for other enzymes.Ficin hydrolysates showed very relevant performance,and suggest that could be appropriate production of functional ingredients. | Afaf Kheroufi María E.Brassesco Débora A.Campos Halima Boughellout Manuela E.Pintado | 2022 | Food Bioscience2022，47，3： | 1 |
| 14 | Robust and stable indirect fuzzy adaptive control for SISO nonlinear systems 显示文摘 | Halima D B Chtourou M | 2009 | International Multi- Conference on Systems Signals and Devices2009，9，6： | 1 |
| 15 | Cellular basis of Alzheimer's disease显示文摘 | Bali J Halima SB Felmy B | 2010 | Ann Indian Acad Neurol2010，13，2： | 1 |
| 16 | Comparison study of ammonia and COD adsorption on zeolite, activated carbon and composite materials in landfill leachate treatment 显示文摘 | Azhar A Halima Hamidi A Azizb Megat Azmi Megat Joharib | 2010 | De- salination2010，262，13： | 1 |
| 17 | Robust and stable indirect fuzzy adaptive control for SISO nonlinear systems显示文摘 | Halima D B Chtourou M | 2009 | International Multiconference on Systems Signals and Devices2009，9，6： | 1 |
| 18 | Indicators of oxidative stress in weanling and pubertal rats following exposure to nicotine via milk 显示文摘 | HALIMA BA | 2010 | Hum Exp Toxicol2010，29，6： | 1 |
| 19 | Social science research in malaria prevention, management and control in the last two decades: An overview显示文摘 | Halima Abdullah Mwenesi | 2005 | Acta Tropica2005，，3： | 1 |
| 20 | Physiologicalresponses of salt stress and osmoprotection withproline in two strains of lactococci isolated fromearners milk in Southern Algeria显示文摘 | Faiza B Halima Z Nour-Eddine K | 2011 | AfricanJournal of Biotechnology2011，10，19： | 1 |
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