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| 1 | Elevated miR-33a and miR-224 in steatotic chronic hepatitis Cliver biopsies显示文摘AIM:To assess the expression of selected microRNAs(miRNA) in hepatitis C,steatotic hepatitis C,noninfected steatotic and normal liver tissues.METHODS:The relative expression levels of miR-21,miR-33 a,miR-96,miR-122,miR-125 b,miR-221 and miR-224 were determined in 76 RNA samples isolated from 18 non-steatotic and 28 steatotic chronic hepatitis C(CHC and CHC-Steatosis,respectively) cases,18 non-infected,steatotic liver biopsies of metabolic origin(Steatosis) and 12 normal formalin-fixed paraffin-embedded liver tissues using TaqMan MicroRNA Assays.All CHC biopsy samples were obtained prior to initiating therapy.Patients' serum biochemical values,which included glucose,triglyceride,cholesterol,alanine aminotransferase(ALT),aspartate aminotransferase(AST),gamma-glutamyl-transferase(GGT),alkaline phosphatase(AP),were obtained and correlated with relative miRNA expression.RESULTS:When compared with control non-infected liver samples,miR-122 and miR-221 levels were reduced in CHC-Steatosis(P < 0.03) and in CHC,CHCSteatosis and Steatosis(P < 0.01).Alternatively,the expression of miR-33 a and miR-224 were elevated in CHC-Steatosis and Steatosis in comparison to control tissue(P < 0.01).The levels of miR-33 a and miR-224 in CHC-Steatosis(P < 0.02) and miR-224 in Steatosis(P < 0.001) were increased in comparison to CHC samples.By contrast,the expression of miR-21 did not differ statistically between diseased and normal liver samples.Levels of miR-33 a correlated negatively with serum AST and AP levels in Steatosis as well as with necroinflammatory grade in CHC,whereas miR-21 correlated positively with AST in Steatosis and displayed negative correlation with triglyceride level in CHC-Steatosis.In contrast,miRNA levels were not correlated with ALT,GGT,cholesterol levels or fibrosis stage.CONCLUSION:Differences in miRNA expression were observed between CHC and steatotic CHC,CHC and steatotic liver,but not between steatotic CHC and steatotic liver of metabolic origin. | Gabor Lendvai Katalin Jármay Gizella Karácsony Tünde Halász Ilona Kovalszky Kornélia Baghy Tibor Wittmann Zsuzsa Schaff András Kiss | 2014 | World Journal of Gastroenterology2014，20，41： | 2 |
| 2 | Defeat is a major stressor in males while social instability is stressful mainly in females:Towards the development of a social stress model in female rats显示文摘 | Hailer J Fuchs E Halàsz J | 1998 | Brain Research Bulletin1998，50，1： | 1 |
| 3 | Effect of bone density on vertebral strength and stiffness after percutaneous vertebroplasty 显示文摘 | Graham J Ahn C Hal N | 2007 | Spine2007，32，18： | 1 |
| 4 | Cloning and expression of the chicken interferon gamma gene显示文摘 | Dig by M R Lowent hal J W | 1995 | Interferon Cytoline Res1995，15，11： | 1 |
| 5 | Significance of urokinase and its inhibitors in the invasiveness and metastasing of malignant tumors显示文摘 | Halámková J Kiss I Tomá(s)aek J | | 0，，02： | 1 |
| 6 | The preparation of nano-sized H ZSM-5 zeolite and its application in the aromatization of methanol 显示文摘 | NI Y M SUN A M WU X L HAl G L HU J L LI T LI G X | 2011 | Microporous and Mesoporous Materials2011，143，2： | 1 |
| 7 | Voriconazole concen- trations and outcome of invasive ftmgal infections 显示文摘 | Miyakis S van Hal S J Marriott D | 2010 | Clin Microbiol lnfect2010，16，： | 1 |
| 8 | Voriconazole concentrations and outcome of invasive fungal infections显示文摘 | MIYAKIS S van HAL SJ RAY J et ol | 2010 | Clin Microbiol Infect2010，16，7： | 1 |
| 9 | The origin of ocular microtremor in man显示文摘 | Spauschus A Marsden J Hal iday DM | | 0，，04： | 1 |
| 10 | Role-Based Access Control Models显示文摘 | Ravi S Sandhu Edward J Coyne Hal L Feinstein | 1996 | IEEE Computer1996，29，2： | 1 |
| 11 | Design of an immobilized enzyme system for naringin hydrolysis at high- pressure显示文摘 | Pedro HAL Alfaia A J Marques J | 2007 | Enzyme and Microbial Technology2007，40，3： | 1 |
| 12 | Laboratory scale investigations ofalgal toxin removal by water treatment显示文摘 | Hal T Hart J Croll R | 2000 | Water EnvironmentalManagement2000，14，1： | 1 |
| 13 | Role-Based Access Control Models显示文摘 | Sandhu Ravi Coyne Edward J Feinstein Hal L | 1996 | IEEE Computer1996，29，2： | 1 |
| 14 | Root system topology and diameter distribution of species from habitats differing in inunda- tion frequency显示文摘 | Bouma T Nielsen L Van Hal J | 2001 | Functional Ecology2001，15，3： | 1 |
| 15 | Clinician ordering practices for voriconazole therapeutic drug monitoring: experiences of a referral laboratory显示文摘 | Miyakis S van Hal SJ Solvag C J | 2010 | Ther Drug Monit2010，32，： | 1 |
| 16 | Role of CX3CR1 (fractalkine receptor) in brain damage and inflammation in- duced by focal cerebral ischemia in mouse显示文摘 | De nes A Ferenczi S Hal a sz J | 2008 | J Cereb Blood Flow Metab2008，28，10： | 1 |
| 17 | Homogeneous cata-lysis of the hydrogenation of olefini compounds by ruthenium(Ⅱ)chloride显示文摘 | Hal J Pem F Harrod B | 1966 | J Am Chem Soe1966，88，： | 1 |
| 18 | Role-based access control models显示文摘 | Ravi S Sandhu Edward J Coyne Hal L Feinstein | 1996 | Computer1996，29，2： | 1 |
| 19 | Role-based access control models显示文摘 | Edward J Coyne Hal L Feinstein | 1996 | IEEE Computer1996，29，2： | 1 |
| 20 | Systematic review and meta- analysis of the significance of heterogeneous vancomycin- intermediate Staphylococcus aureus isolates显示文摘 | VAN HAL S J PATERSON DL | 2011 | Antimicrob Agents Chemother2011，55，1： | 1 |
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