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| 1 | Magnetoelectric effect generated through electron transfer from organic radical to metal ion显示文摘Magnetoelectric(ME)materials induced by electron transfer are extremely rare.Electron transfer in these materials invariably occurs between the metal ions.In contrast,ME properties induced by electron transfer from an organic radical to a metal ion have never been observed.Here,we report the ME coupling effect in a mononuclear molecule-based compound[(CH_(3))_(3)NCH_(2)CH_(2)Br][Fe(Cl_(2)An)_(2)(H_(2)O)_(2)](1)[Cl_(2)An=chloranilate,(CH_(3))_(3)NCH_(2)CH_(2)Br+=(2-bromoethyl)trimethylammonium].Investigation of the mechanism revealed that the ME coupling effect is realized through electron transfer from the Cl_(2)An to the Fe ion.Measurement of the magnetodielectric(MD)coefficient of 1 indicated a positive MD of up to~12%at 103.0Hz and 370 K,which is very different from that of ME materials with conventional electron transfer for which the MD is generally negative.Thus,the current work not only presents a novel ME coupling mechanism,but also opens a new route to the synthesis of ME coupling materials. | Xiaolin Liu Qiang Liu Haixia Zhao Guilin Zhuang Yanping Ren Tao Liu Lasheng Long Lansun Zheng | 2023 | National Science Review2023，10，4： | 0 |
| 2 | Mup-knockout mice generated through CRISPR/ Cas9-mediated deletion for use in urinary protein analysis显示文摘主要尿蛋白质(MUP ) 是在老鼠尿的最丰富的蛋白质种类,为超过 90% 全部的蛋白质内容的财务。21 Mup 基因和 21 pseudogenes 在染色体 4 上在约 2 megabase 对(Mbp ) 的一个区域被聚类。一个 Mup 大美人老鼠模型将极大地在老鼠尿的 proteomic 分析的领域里便于研究。这里,我们用 CRISPR/Cas9 系统报导 2.2 Mbp 的 Mup 基因簇的成功的大美人。同型结合的 Mup 大美人老鼠幸存到成人生活并且没展出明显的缺点。non-MUP 的 proteomes 的模式在同型结合的 Mup 大美人老鼠的尿蛋白质类似于钠 dodecyl 硫酸盐 polyacrylamide 胶化电气泳动判定的野类型的老鼠的那些。连接酶的 immunosorbent 试金的敏感显著地在 Mup 大美人提高了老鼠检测尿蛋白质是的 non-MUP。简言之,我们开发了一个 Mup 大美人老鼠模型。这个老鼠模型将是有用的因为测试那的尿 biomarker 的研究可以为人有关联。 | Haixia Yang Wei Zhang Shan Lu Guangqing Lu Hongjuan Zhang Yinghua Zhuang Yue Wang Mengqiu Dong Yu Zhang Xingang Zhou Peng Wang Lei Yu Fengchao Wang Liang Chen | 2016 | Acta Biochimica et Biophysica Sinica2016，48，5： | 0 |
| 3 | A Smart Wearable Ring Device for Sensing Hand Tremor of Parkinson’s Patients显示文摘Parkinson’s disease(PD)is a very common neurodegenerative disease that occurs mostly in the elderly.There are many main clinical manifestations of PD,such as tremor,bradykinesia,muscle rigidity,etc.Based on the current research on PD,the accurate and convenient detection of early symptoms is the key to detect PD.With the development of microelectronic and sensor technology,it is much easier to measure the barely noticeable tremor in just one hand for the early detection of Parkinson’s disease.In this paper,we present a smart wearable device for detecting hand tremor,in which MPU6050(MIDI Processing Unit)consisting of a 3-axis gyroscope and a 3-axis accelerometer is used to collect acceleration and angular velocity of fingers.By analyzing the time of specific finger movements,we successfully recognized the tremor signals with high accuracy.Meanwhile,with Bluetooth 4.0(Bluetooth Low Energy,BLE)and networking terminal ability,tremor data can be transferred to a monitoring device in real time with extremely lowenergy consumption.The experimental results have shown that the proposed device(smart ring)is convenient for long-term tremor detection which is vital for early detection and treatment for Parkinson’s disease. | Haixia Yang Yixian Shen Wei Zhuang Chunming Gao Dong Dai Weigong Zhang | 2021 | Computer Modeling in Engineering & Sciences2021，，3： | 0 |
| 4 | Mup-knockout mice generated through CRISPR/Cas9-mediated deletion for use in urinary protein analysis显示文摘The originally published version of this manuscript contained incomplete funding information. The funding information has since been updated to read as follows. | Haixia Yang Wei Zhang Shan Lu Guangqing Lu Hongjuan Zhang Yinghua Zhuang Yue Wang Mengqiu Dong Yu Zhang Xingang Zhou Peng Wang Lei Yu Fengchao Wang Liang Chen | 2019 | Acta Biochimica et Biophysica Sinica2019，51，6： | 0 |
| 5 | RNF6 promotes chronic myelogenous leukemia cell proliferation and migration by stabilizing vimentin via multiple atypical ubiquitinations显示文摘Chronic myelogenous leukemia(CML)is a malignancy from bone marrow myeloid stem cells mainly driven by the fusion gene BCR-ABL.In addition to BCR-ABL,other genes including RNF6 are also dysregulated in CML cells.1 RNF6,a ubiquitin ligase of the RING family,promotes various cancer cell proliferation,chemoresistance,and tumor growth in vivo by targeting various proteins for ubiquitination and degradation,including SHP1,TLE3,FOXA1,and MAD1.^(2) However,its specific mechanism in CML is not known. | Hongxia Zhang Yueya Zhong Yuanming He Yujia Xu Ying Ren Haixia Zhuang Tong Sun Zhigang Zhu Xinliang Mao | 2024 | Genes & Diseases2024，11，1： | 0 |
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