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| 1 | Expression of neurocan mRNA and ultrastructure of brain tissue after cerebral ischemia and reperfusion in stroke-prone renovascular hypertensive rats treated by electroacupuncture显示文摘We established a stroke-prone renovascular hypertensive rat model by bilateral constriction of the renal artery with sliver loop clips. After ten weeks, middle cerebral artery occlusion was induced for 2 hours. The rats then received electro-acupuncture at Baihui (DU 20) and Dazhui (DU 14) after onset of ischemia for 30 days. In situ hybridization study showed that electroacupuncture significantly reduced the number of neurocan mRNA-positive cells in the ischemic penumbra and hippocampal tissues of rats. Electron microscopy results demonstrated that the structure of neurons and blood vessels in the ischemic tissues were restored with electroacupuncture. Overall, these data suggest that electroacupuncture may protect neurons against ischemic reperfusion injury in stroke-prone renovascular hypertensive rats, which may be regulated by downregulation of expression of nerve inhibitory factor neurocan mRNA. | Feng Tan Saiying Wan Haike Wu Qiwen HUO Jinliang Wang Wenlin Chen Meifeng Fang Xiaolin Liu Xuewen Wang Jingbo Sun | 2011 | Neural Regeneration Research2011，6，36： | 8 |
| 2 | Medical expenditures for colorectal cancer diagnosis and treatment: A 10-year high-level-hospital-based multicenter retrospective survey in China, 2002-2011显示文摘Objective: Colorectal cancer(CRC) causes a substantial burden of disease in China and the evidence of economic burden triggered is fundamental for priority setting. The aim of this survey was to quantify medical expenditures and the time trends for CRC diagnosis and treatment in China.Methods: From 2012 to 2014, a hospital-based multicenter retrospective survey was conducted in 13 provinces across China. For each eligible CRC patient diagnosed from 2002 to 2011, clinical information and expenditure data were extracted using a uniform questionnaire. All expenditure data were reported in Chinese Yuan(CNY)using 2011 values.Results: Of the 14,536 CRC patients included, the average age at diagnosis was 58.2 years and 15.8% were stageI cases. The average medical expenditure per patient was estimated at 37,902 CNY [95 % confidence interval(95%CI): 37,282-38,522], and the annual average increase rate was 9.2% from 2002 to 2011(P for trend <0.001), with a cumulative increase of 2.4 times(from 23,275 CNY to 56,010 CNY). The expenditure per patient in stages Ⅰ, Ⅱ, Ⅲ and Ⅳ were 31,698 CNY, 37,067 CNY, 38,918 CNY and 42,614 CNY, respectively(P<0.001). Expenditure significantly differed within various subgroups. Expenses for drugs contributed the largest proportion(52.6%).Conclusions: These conservative estimates illustrated that medical expenditures for CRC diagnosis and treatment in tertiary hospitals in China were substantial and increased rapidly over the 10 years, with drugs continually being the main expense by 2011. Relatively, medical expenditures are lower for CRC in the earlier stages. These findings will facilitate the economic evaluation of CRC prevention and control in China. | Jufang Shi Guoxiang Liu Hong Wang Ayan Mao Chengcheng Liu Lanwei Guo Huiyao Huang Jiansong Ren Xianzhen Liao Yana Bai Xiaojie Sun Xinyu Zhu Jialin Wang Bingbing Song Jinyi Zhou Lin Zhu Haike Lei Yuqin Liu Yunyong Liu Lingbin Du Yutong He Kai Zhang Ni Li Wanqing Chen Min Dai Jie He | 2019 | Chinese Journal of Cancer Research2019，31，5： | 8 |
| 3 | No expenditure difference among patients with liver cancer at stageⅠ-ⅣV:Findings from a multicenter cross-sectional study in China显示文摘Objective:The number of liver cancer patients in China accounts for more than half of the world.However,China currently lacks national,multicenter economic burden data,and meanwhile,measuring the differences among different subgroups will be informative to formulate corresponding policies in liver cancer control.Thus,the aim of the study was to measure the economic burden of liver cancer by various subgroups.Methods:A hospital-based,multicenter and cross-sectional survey was conducted during 2012・2014,covering 39 hospitals and 21 project sites in 13 provinces across China.The questionnaire covers clinical information,sociology,expenditure,and related variables.All expenditure data were reported in Chinese Yuan(CNY)using 2014 values.Results:A total of 2,223 liver cancer patients were enrolled,of whom 59.61%were late-stage cases(III-IV),and 53.8%were hepatocellular carcinoma.The average total expenditure per liver cancer patient was estimated as 53,220 CNY,including 48,612 CNY of medical expenditures(91.3%)and 4,608 CNY of non-medical expenditures(8.7%).The average total expenditures in stage I,H,m and stage IV were 52,817 CNY,50,877 CNY,50,678 CNY and 54,089 CNY(P>0.05),respectively.Non-medical expenditures including additional meals,additional nutrition care,transportation,accommodation and hired informal nursing were 1,453 CNY,839 CNY,946 CNY,679 CNY and 200 CNY,respectively.The one-year out-of-pocket expenditure of a newly diagnosed patient was 24,953 CNY,and 77.2%of the patients suffered an unmanageable financial burden.Multivariate analysis showed that overall expenditure differed in almost all subgroups(P<0.05),except for sex,clinical stage,and pathologic type.Conclusions:There was no difference in treatment expenditure for liver cancer patients at different clinical stages,which suggests that maintaining efforts on treatment efficacy improvement is important but not enough.To fiirtherly reduce the overall economic burden from liver cancer,more effort should be given to primary and secondary prevention strategies. | Haike Lei Lin Lei Jufang Shi Yongzhong Wu Ling Liang Huiyao Huang Mei He Fangzhou Bai Maomao Cao Hui Qiu Yuting Wang Chengcheng Liu Jia Du Hong Wang Yan Zhang Mengdi Cao Ji Peng Ni Li Chunfeng Qu Min Dai Wanqing Chen Jie He | 2020 | Chinese Journal of Cancer Research2020，32，4： | 7 |
| 4 | Modeling and optimization of a single-drive push–pull silicon Mach–Zehnder modulator显示文摘We present an equivalent circuit model for a silicon carrier-depletion single-drive push–pull Mach–Zehnder modulator(MZM)with its traveling wave electrode made of coplanar strip lines.In particular,the partialcapacitance technique and conformal mapping are used to derive the capacitance associated with each layer.The PN junction is accurately modeled with the fringe capacitances taken into consideration.The circuit model is validated by comparing the calculations with the simulation results.Using this model,we analyze the effect of several key parameters on the modulator performance to optimize the design.Experimental results of MZMs confirm the theoretical analysis.A 56 Gb/s on–off keying modulation and a 40 Gb/s binary phase-shift keying modulation are achieved using the optimized modulator. | Yanyang Zhou Linjie Zhou Haike Zhu Chiyan Wong Yida Wen Lei Liu Xinwan Li Jianping Chen | 2016 | Photonics Research2016，4，4： | 5 |
| 5 | Silicon high-speed binary phase-shift keying modulator with a single-drive push–pull high-speed traveling wave electrode显示文摘We demonstrate binary phase shift keying(BPSK) modulation using a silicon Mach–Zehnder modulator with aπ-phase-shift voltage(Vπ) of-4.5 V.The single-drive push–pull traveling wave electrode has been optimized using numerical simulations with a 3 dB electro-optic bandwidth of 35 GHz.The 32 Gb/s BPSK constellation diagram is measured with an error vector magnitude of 18.9%. | Jinting Wang Linjie Zhou Haike Zhu Rui Yang Yanyang Zhou Lei Liu Tao Wang Jianping Chen | 2015 | Photonics Research2015，3，3： | 4 |
| 6 | Antioxidant capacity of extract from Jiangtang Xiaozhi recipe in vitro显示文摘OBJECTIVE: To evaluate the antioxidant capacity of the extract from Jiangtang Xiaozhi recipe(JXR) of in vitro.METHODS: JXR extract was prepared according to previously reported method. In vitro antioxidant assays were used in this experiment, including 1,1-Diphenyl-2-picrylhydrazyl free radical(DPPH) radical scavenging ability, 2-2’-Azinobis-(3-ethylbenzthiazoline-6-sul phonate(ABTS) radical scavenging ability, reducing power assay, fluorescence recovery after photo bleaching assay, β-carotene bleaching assay, ferric thiocyanate assay, and thiobarbituric acid method.RESULTS: DPPH, ABTS assay showed that JXR extract had distinct effect on scavenging free radicals;reducing power and ferricreducing-antioxidant power assay showed that JXR extract possessed redox ability;β-Carotene bleaching assay and antioxidant activity in a linoleic acid system using ferric thiocyanate method, thiobarbituric acid assay indicated that JXR extract could effectively inhibit lipid peroxidation, and the effect was better than that of Vitamin C.CONCLUSION: JXR extract has significant antioxidant capacity in vitro. | Song Wang Yuan Yuan Yu Naixin Gu Haike Zhou Yunfeng Chen Xigong Wang Shuaiyu Fan Kai Ge Zhengyan Jin Long Xu Yang | 2020 | Journal of Traditional Chinese Medicine2020，40，3： | 3 |
| 7 | Solubilities of 1,2,3-trimethylbenzene and 1,2,4-trimethylbenzene and 1,3,5-trimethylbenzene in t-butyl alcohol+water mixtures and hydrophobic interaction显示文摘 | Lizhuang Zou Guanying Yang Buxing Han Ruilin Liu Haike Yan | 1999 | Science in China Series B: Chemistry1999，，4： | 1 |
| 8 | Solubilities of benzene, toluene and diphenyl in the t-butyl alcohol+water mixtures and hydrophobic interaction显示文摘 | Lizhuang Zou Guanying Yang Buxing Han Ruilin Liu Haike Yan | 1999 | Science in China Series B: Chemistry1999，，3： | 1 |
| 9 | Peripheral nerve tumors of the orbit显示文摘 | Carroll GS Haik BG Fleming JC | 1999 | Radiologic Clinics of North America1999，7，： | 1 |
| 10 | Solubility of ethane int-butanol + water mixtures and a hydrophobic interaction study显示文摘 | Peixun Li Yilin Wang Buxing Han Haike Yan Ruilin Liu | 1996 | Journal of Solution Chemistry1996，，12： | 1 |
| 11 | Superresolution reconstruction of a video captured by a vibrated time delay and integration camera 显示文摘 | Oren Haik Yitzhak Yitzhaky | 2006 | Journal of Electronic Image(S1017-9909)2006，15，2： | 1 |
| 12 | Effect of fluoroethy- lene carbonate (FEC) on the performance and surface chemistry of Si-nanowire Li-ion battery anodes显示文摘 | Etacheri V Haik O Goffer Y | 2012 | Lang- muir2012，28，1： | 1 |
| 13 | Blind restoration of atmospherically degraded images by automatic best step-edge detection显示文摘 | O Shacham O Haik Y Yitzhaky | 2007 | Pattern Recognition Letters2007，28，15： | 1 |
| 14 | Detecting and tracking mov- ing objects in long-distance imaging through turbulent me- dium显示文摘 | Chen E Haik O Yitzhaky Y | 2014 | Applied Optics2014，53，6： | 1 |
| 15 | The hatchet and bilobed flaps revisited: shedding new light on traditional concepts 显示文摘 | Zihnsky I Father N Haik J | 2012 | J Drugs Dermatol2012，11，1： | 1 |
| 16 | Modification and characterization of polystyrene-based magnetic microspheres and comparison with albumin-based magnetic microspheres显示文摘 | Yousef Haik Ching-Jen Chen | 2001 | Journal of Magnetism and Magnetic Materials2001，225，： | 1 |
| 17 | Development of magnetic device for cell separation显示文摘 | Haik Y Pai V Che C J | 1999 | J Magn Magn Mater1999，194，123： | 1 |
| 18 | Superresolution reconstruction of a video captured by a vibrated time delay and integration camera显示文摘 | Oren Haik Yitzhak Yitzhaky | 2006 | Journal of Electronic Image (ISSN: 1017-9909)2006，15，02： | 1 |
| 19 | Photodynamic therapy of cutaneous lymphoma using 5-aminolevulinic acid topical application显示文摘 | Orenstein A Haik J Tamir J | 2000 | Dermatol Surg2000，26，8： | 1 |
| 20 | Modification and Characteriza- tion of Polystyrene-Based Magnetic Microspheres and Comparison with Albumin-Based Magnetic Microspheres显示文摘 | Chatterjee J Haik Y Chen C J | 2001 | Journal of mag- netism and magnetic materials2001，225，1： | 1 |
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