|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A growing field: the regulation of axonal regeneration by Wnt signaling显示文摘The canonical Wnt/β-catenin pathway is a highly conserved signaling cascade that plays critical roles during embryogenesis. Wnt ligands regulate axonal extension, growth cone guidance and synaptogenesis throughout the developing central nervous system(CNS). Recently, studies in mammalian and fish model systems have demonstrated that Wnt/β-catenin signaling also promotes axonal regeneration in the adult optic nerve and spinal cord after injury, raising the possibility that Wnt could be developed as a therapeutic strategy. In this review, we summarize experimental evidence that reveals novel roles for Wnt signaling in the injured CNS, and discuss possible mechanisms by which Wnt ligands could overcome molecular barriers inhibiting axonal growth to promote regeneration. A central challenge in the neuroscience field is developing therapeutic strategies that induce robust axonal regeneration. Although adult axons have the capacity to respond to axonal guidance molecules after injury, there are several major obstacles for axonal growth, including extensive neuronal death, glial scars at the injury site, and lack of axonal guidance signals. Research in rodents demonstrated that activation of Wnt/β-catenin signaling in retinal neurons and radial glia induced neuronal survival and axonal growth, but that activation within reactive glia at the injury site promoted proliferation and glial scar formation. Studies in zebrafish spinal cord injury models confirm an axonal regenerative role for Wnt/β-catenin signaling and identified the cell types responsible. Additionally, in vitro and in vivo studies demonstrated that Wnt induces axonal and neurite growth through transcription-dependent effects of its central mediator β-catenin, potentially by inducing regeneration-promoting genes. Canonical Wnt signaling may also function through transcription-independent interactions of β-catenin with cytoskeletal elements, which could stabilize growing axons and control growth cone movement. Therefore, these studies suggest that Wnt-induced pathways responsible for regulating axonal growth during embryogenesis could be repurposed to promote axonal growth after injury. | Armando L. Garcia Adanna Udeh Karthik Kalahasty Abigail S. Hackam | 2018 | Neural Regeneration Research2018，13，1： | 10 |
| 2 | Buflomedil reduced cardiovascular events in peripheral arterial disease显示文摘 | Hackam DG | 2008 | Evid Based Med2008，13，5： | 1 |
| 3 | Chemical changes at the surface of RTV silicone rubber coatings on insu- lators during dry-band arcing 显示文摘 | Seog-Hyeon Kim Cherney E A Hackam R | 1994 | IEEE Transactions on Die- lectrics and Electrical Insulation1994，1，1： | 1 |
| 4 | Carvedilol:a third-generationβ-blocker should be a first-choiceβ-blocker显示文摘 | DiNicolantonio JJ Hackam DG | 2012 | Expert Rev Cardiovasc Ther2012，10，1： | 1 |
| 5 | Statins and sepsis: multiple modifications at multiple levels显示文摘 | Marius Terblanche Yaniv Almog Robert S Rosenson Terry S Smith Daniel G Hackam | 2007 | The Lancet Infectious Diseases2007，，5： | 1 |
| 6 | Outdoor HV composite polymeric insulator显示文摘 | Hackam R | 1999 | IEEE Transactions on Dielectrics and Electrical Insulation1999，6，5： | 1 |
| 7 | Buflomedil reduced cardiovascular events in peri- pheral arterial disease显示文摘 | HACKAM DG | 2008 | Evid Based Med2008，13，5： | 1 |
| 8 | An- giotensin inhibition in renovascular disease: a popula- tion-based cohort study显示文摘 | Hackam D G Duong-Hua M L Mamdani M | 2008 | Am Heart J2008，156，3： | 1 |
| 9 | Emerging risk factors for atherosclerotic vascular disease:a critical review of the evidence显示文摘 | Daniel G Hackam MD Sonia S | | 0，，07： | 1 |
| 10 | Suppression mechanism of leakage current on RTV coated porcelain and silicone rubber insulators显示文摘 | Kim S H Cherney E A Hackam R | 1991 | IEEE Transactions on Power Delivery1991，4，6： | 1 |
| 11 | Emerging risk factors for atherosclerotic vascular disease 显示文摘 | Hackam DG Anand SS | 2003 | JAMA2003，290，7： | 1 |
| 12 | Emerging risk factors for atherosclerotic vascular disease:a critical review of the evidence显示文摘 | Hackam DG Anand SS | 2003 | JAMA2003，290，7： | 1 |
| 13 | ac (50 Hz) and dc electrical breakdown of vacuum gaps and with variation of air pressure in the range 10-9-10-2 Torr using OFHC copper, nickel, aluminum, and niobium parallel planar electrodes显示文摘 | Hackam R Ahcheh L | 1975 | Journal of Ap- plied Physics1975，46，2： | 1 |
| 14 | Single-stage repair of Hirschsprung's disease: A comparison of 109 patients over 5 years 显示文摘 | Hackam DJ Superina RA Pearl RH | 1997 | J Pediatr Surg1997，32，7： | 1 |
| 15 | The loss and recovery of hydrophobicity of RTV silicone rubber insulator coatings 显示文摘 | Kim S H Chemey E A Hackam R | 1990 | IEEE Transactions on Power Delivery1990，3，5： | 1 |
| 16 | Surface flashover of solid insulator in atmospheric air and in vacuum显示文摘 | Pillai A S Hackam R | 1985 | Journal of Applied Physics1985，58，1： | 1 |
| 17 | Surface flashover of solid insulators in atmospheric air and in vacuum显示文摘 | Sivathanu A Hackam R | 1985 | J Appl Phys1985，58，1： | 1 |
| 18 | Human embryonic and neuronal stem cell markers in retinoblastoma显示文摘 | Seigel GM Hackam AS Ganguly A Mandell LM Gonzalez - Fernandez F | 2007 | Mol Vis2007，13，： | 1 |
| 19 | Management of risk inperipheral artery disease:Recent therapeutic advances显示文摘 | Hackam DG Goodman SG Anand SS | 2005 | Am Heart J2005，150，1： | 1 |
| 20 | Evidence- based feeding strate- gies before and after the development of necrotizing enterocolitis 显示文摘 | Good M Sodhi CP Hackam DJ | 2014 | Expert Rev Clin Immunol2014，10，7： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员