6篇
您的检索式：作者名="Haakonsson"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Metabolic programming determines the lineage-differentiation fate of murine bone marrow stromal progenitor cells显示文摘Enhanced bone marrow adipogenesis and impaired osteoblastogenesis have been observed in obesity,suggesting that the metabolic microenvironment regulates bone marrow adipocyte and osteoblast progenitor differentiation fate.To determine the molecular mechanisms,we studied two immortalized murine cell lines of adipocyte or osteoblast progenitors(BMSCs^adipo and BMSC^sosteo,respectively)under basal and adipogenic culture conditions.At baseline,BMSCs^adipo,and BMSCs^osteo exhibit a distinct metabolic program evidenced by the presence of specific global gene expression,cellular bioenergetics,and metabolomic signatures that are dependent on insulin signaling and glycolysis in BMSCs^osteo versus oxidative phosphorylation in BMSCs^adipo.To test the flexibility of the metabolic program,we treated BMSCsadipo with parathyroid hormone,S961(an inhibitor of insulin signaling)and oligomycin(an inhibitor of oxidative phosphorylation).The treatment induced significant changes in cellular bioenergetics that were associated with decreased adipocytic differentiation.Similarly,12 weeks of a high-fat diet in mice led to the expansion of adipocyte progenitors,enhanced adipocyte differentiation and insulin signaling in cultured BMSCs.Our data demonstrate that BMSC progenitors possess a distinct metabolic program and are poised to respond to exogenous metabolic cues that regulate their differentiation fate. | Michaela Tencerova Elizabeth Rendina-Ruedy Ditte Neess Nils Faergeman Florence Figeac Dalia Ali Morten Danielsen Anders Haakonsson Clifford J.Rosen Moustapha Kassem | 2019 | Bone Research2019，7，4： | 1 |
| 2 | PPAR/ and the global map of adipogenesis and beyond 显示文摘 | Lefterova MI Haakonsson AK Lazar MA | 2014 | Trends En- docrinol Metab2014，25，6： | 1 |
| 3 | A co-evolutionary perspective on the drivers of international sourcing of pharmaceuti- cal R&D to India 显示文摘 | Haakonsson S J Jensen P D Q Mudambi S M | 2013 | Journal of Economic Geography2013，13，4： | 1 |
| 4 | The Changing Governance Structures of the Global Pharmaceutical Value Chain 显示文摘 | Haakonsson S | 2009 | Competition and Chance2009，，1： | 1 |
| 5 | A co-evolution- aryperspective on the drivers of international sourcing of pharma- ceutical R&D to India 显示文摘 | Haakonsson S J Jensen P D Q Mudambi S M | 2013 | Journal of Economic Geography2013，13，4： | 1 |
| 6 | How Failure to Align Organizational Climate and Leadership Style Affects Performance显示文摘 | HAAKONSSON D D BURTON R M OBEL B | 2008 | Man- agement Decision2008，46，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员