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| 1 | Long-term monitoring of PCDD/PCDF and other unintentionally produced POPs-Concepts and case studies from Europe显示文摘During the start-up and unstable combustion periods,even the state-of-the-art incinerators emit polychlorinated dibenzo-p-dioxins and dibenzofurans(PCDD/PCDF) in stack gases at concentrations that are up to 1000 times higher than normal operation. Therefore,incinerators and other sources with variation of PCDD/PCDF release into air cannot be reliably monitored by the conventional short-term sampling that covers only 0.1%to 0.2%of the yearly operating time.A more comprehensive monitoring regime is required.This paper describes different applications of continuous PCDD/PCDF sampling in some European countries.The cases demonstrate that flexible regimes for continuous sampling can be crafted and applied by governments or regional/local authorities.Such regimes range from a countrywide,continuous requirement for selected facility types(e.g.,waste incinerators) to a facility-specific regime that applies,for example,to new facilities for a defined time period until the facility has demonstrated continuous compliance with regulatory limits. Countries implementing the Stockholm Convention are suggested to evaluate in their Best available technology/Best environmental practice(BAT/BEP) activities the usefulness of long-term sampling by,for example,designating institutes related to the environmental ministry or regional authorities to supervise long-term sampling regimes at relevant facilities in their country/areas,beginning with priority sources(e.g.,facilities used for destruction of persistent organic pollutants(POPs) or hazardous waste processing) . This paper presents and discusses the results of the AMESA long-term monitoring system having demonstrated that in addition to PCDD/PCDF all other unintentionally produced POPs listed in the Stockholm Convention could be supervised. | REINMANN Jürgen WEBER Roland HAAG Roland | 2010 | Science China Chemistry2010，53，5： | 8 |
| 2 | Palliative chemotherapy for gastroesophageal cancer in old and very old patients: A retrospective cohort study at the National Center for Tumor Diseases, Heidelberg显示文摘AIM:To investigate the outcome of palliative chemotherapy in old patients with gastroesophageal cancer at the National Center for Tumor Diseases,Heidelberg.METHODS:Using a prospectively generated database,we retrospectively analyzed 55 patients≥70years under palliative chemotherapy for advanced gastroesophageal cancer at the outpatient clinic of the National Center for Tumor Diseases Heidelberg,Germany between January 2006 and December2013.Further requirements for inclusion were(1)histologically proven diagnosis of gastroesophageal cancer;(2)advanced(metastatic or inoperable)disease;and(3)no history of radiation or radiochemotherapy.The clinical information included Eastern Cooperative Oncology Group performance status(ECOG PS),presence and site of metastases at diagnosis,date of previous surgery and perioperative chemotherapy,start and stop date of first-line treatment,toxicities and consecutive dosage reductions of first-line treatment,response to first-line therapy,date of progression,usage of second-line therapies and date and cause of death.Survival times[progression-free survival(PFS),overall survival(OS)and residual survival(RS)]were calculated.Toxicity and safety were examined.Prognostic factors including ECOG PS,age and previousperioperative treatment were analyzed.RESULTS:Median age of our cohort was 76 years.86%of patients received a combination of two cytotoxic drugs.76 percent of patients had an oxaliplatin-based first-line therapy with the oxaliplatin and 5-fluorouracil regimen being the predominantely chosen regimen(69%).Drug modifications due to toxicity were necessary in 56%of patients,and 11%of patients stopped treatment due to toxicities.Survival times of our cohort are in good accordance with the major phaseⅢtrials that included mostly younger patients:PFS and OS were 5.8 and 9.5 mo,respectively.Survival differed significantly between patient groups with low(≤1)and high(≥2)ECOG PS(12.7 mo vs 3.8 mo,P<0.001).Very old patients(≥75 years)did not show a worse outcome in terms of survival.Patients receiving secondline treatment(51%)had a significantly longer RS than patients with best supportive care(6.8 vs 1.4 mo,P=0.001).Initial ECOG PS was a strong prognostic factor for PFS,OS and RS.CONCLUSION:Old patients with non-curable gastroesophageal cancer should be offered chemotherapy,and ECOG PS is a tool for balancing benefit and harm upfront.Second-line treatment is reasonable. | Anne Katrin Berger Stefanie Zschaebitz Christine Komander Dirk Jger Georg Martin Haag | 2015 | World Journal of Gastroenterology2015，21，16： | 6 |
| 3 | IL-1 and BMPs interactive players of cartilage matrix degradation and regeneration 显示文摘 | AIGNER T SOEDER S HAAG J | 2006 | Eur Cell Mater2006，12，： | 1 |
| 4 | A phase Ⅱ study of paclitaxel, weekly, 24-hour continuous infusion 5-fluorouracil, folinic acid and cisplatin in patients with advanced gastric cancer显示文摘 | Kollmannsberger C Quietzsch D Haag C | 2000 | Br J Cancer2000，83，4： | 1 |
| 5 | Two years of clinical experience with procera titanium crowns 显示文摘 | Milleding P Haag P Neroth B | 1998 | Int J prosthodont1998，11，： | 1 |
| 6 | Advantages of positron emission tomography in mediastinal staging of non small cell lung cancer显示文摘 | Von Haag DW Follette DM Roberts PF | 2002 | J Surg Res2002，103，2： | 1 |
| 7 | Alage bloom again显示文摘 | Haag A | 2007 | Nature2007，447，： | 1 |
| 8 | Assessing the relative efficiency of agricultural production units in the Blackland Prairie, Texas 显示文摘 | Haag S Jaska P Semple J | 1992 | Applied Economics1992，24，5： | 1 |
| 9 | Central administra- tion of ghrelin alters emotional responses in rats: behaviou- ral, electrophysiological and molecular evidence显示文摘 | Hansson C Haage D Taube M | 2011 | Neuro- science2011，180，： | 1 |
| 10 | Design of an electric propulsion system for a quadrotor unmanned aerial vehicle显示文摘 | STEPANIAK M J van GRAAS F HAAG M U | 2009 | Journal of Aircraft2009，46，3： | 1 |
| 11 | Inducing effects of dioxin-like polychlorinated biphenyls on CYP1A in the human hepatoblastoma cell line Hep G2,the rat hepatoma cell line H4IIE,and rat primary hepatocytes:Comparison of relative potencies显示文摘 | Zeiger M Haag R Hckel J | 2001 | Toxicological Sciences2001，63，1： | 1 |
| 12 | Pereutaneous venous thrombectomy using the Arrow-Trerotola pereutaneous thrombolytie device (PTD) with temporary caval filtration:in vitro investigations显示文摘 | Wildberger JE Haage P Bovelander J | 2005 | Cardiovase Intervent Radiol2005，28，2： | 1 |
| 13 | The measurement of bullet deflection by intervening objects and the study of bullet behavior after impact显示文摘 | Haag L C | 1987 | AFTE J1987，19，： | 1 |
| 14 | Echinococcus granulosus antigen B is encoded by a gene family 显示文摘 | Chemale G Haag KL Ferreira HB | 2001 | Mol Biochem Parasitol2001，116，2： | 1 |
| 15 | Duration of antihypertensive drug use and risk of dementia: A prospective cohort study 显示文摘 | M D M Haag A Hofman P J Koudstaal | 2009 | Neurology2009，，72： | 1 |
| 16 | Positive-selection vector for direct protein expression 显示文摘 | Haag A F Ostermeier C | 2009 | Biotechniques2009，46，6： | 1 |
| 17 | Memory for public events in paticnts with unilateral temporal labe epilepsy显示文摘 | Haag A Barth S Zibelius M | | 0，，： | 1 |
| 18 | Inhibition by pesticides ofstarter cultures for malolactic fermentation in wine显示文摘 | HAAG V B KREIGER S HAMMES W P | 1988 | Wein Wissens-chaft1988，43，： | 1 |
| 19 | Is there a benefit fromintensified medical and psychological interventions in patientswith functional dyspepsia not responding to conventionaltherapy? 显示文摘 | Haag S Senf W Tagay S | 2007 | Aliment Pharmacol Ther2007，25，8： | 1 |
| 20 | Polymer therapeutics: concepts and applications 显示文摘 | HAAG R KRATZ F | 2006 | Angew Chern Int Ed2006，45，8： | 1 |
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