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| 1 | CD24 expression predicts distant metastasis in extrahepatic bile duct cancer显示文摘AIM: To evaluate the prognostic significance of CD24 expression in patients undergoing adjuvant chemoradiotherapy for extrahepatic bile duct (EHBD) cancer. METHODS: Eighty-four patients with EHBD cancer who underwent curative resection followed by adjuvant chemoradiotherapy were enrolled in this study. Postoperative radiotherapy was delivered to the tumor bed and regional lymph nodes up to a median of 40 Gy (range: 40-56 Gy). All patients also received fluoropyrimidine chemotherapy for radiosensitization during radiotherapy. CD24 expression was assessed with immunohistochemical staining on tissue microarray. Clinicopathologic factors as well as CD24 expression were evaluated in multivariate analysis for clinical outcomes including loco-regional recurrence, distant metastasisfree and overall survival. RESULTS: CD24 was expressed in 36 patients (42.9%). CD24 expression was associated with distant metastasis, but not with loco-regional recurrence nor with overall survival. The 5-year distant metastasis-free survival rates were 55.1% and 29.0% in patients with negative and positive expression, respectively (P=0.0100). On multivariate analysis incorporating N stage, histologic differentiation and CD24 expression, N stage was the only significant factor predicting distant metastasis-free survival (P=0.0089), while CD24 expression had borderline significance (P=0.0733). In subgroup analysis, CD24 expression was significantly associated with 5-year distant metastasis-free survival in node-positive patients (38.4% with negative expression vs 0% with positive expression, P=0.0110), but not in nodenegative patients (62.0% with negative expression vs 64.0% with positive expression,P=0.8599). CONCLUSION: CD24 expression was a significant predictor of distant metastasis for patients undergoing curative resection followed by adjuvant chemoradiotherapy especially for node-positive EHBD cancer. | Kyubo Kim Hye Sook Min Eui Kyu Chie Jin-Young Jang Sun Whe Kim Sae-Won Han Do-Youn Oh Seock-Ah Im Tae-You Kim Yung-Jue Bang Ja-June Jang Sung W Ha | 2013 | World Journal of Gastroenterology2013，19，9： | 2 |
| 2 | Structure and properties of miemfibrillar poly(vinyl alcohol) fibres prepared by saponification under sheafing force of poly( vinyl pivalate) 显示文摘 | Lyoo W S Ha W S | 1996 | Polymer1996，37，14： | 1 |
| 3 | Inhibition of tyrosinase and lipoxygenase activities by resveratrol and its derivatives from seeds of Paeonia lactiflora显示文摘 | Kim H J Ha S C Choi S W | 2002 | Nutraceuticals and Food2002，7，4： | 1 |
| 4 | Properties of dynamically vulcanized EPDM and LLDPE blends显示文摘 | Kim K H Cho W J Ha C S | 1996 | J Appl Polym Sci1996，59，2： | 1 |
| 5 | Application of sequence characterized amplified region(SCAR) analysis to authenticate Panax species and their adulterants显示文摘 | Wang J Ha W Y Ngan F N | 2001 | Planta ivied2001，67，8： | 1 |
| 6 | Prediction of collapse in femoral head osteonecrosis:a modified Kerboul method with use of magnetic resonance images显示文摘 | HA Y C JUNG W H KIM J R | 2006 | J Bone Joint Surg Am2006，88，3： | 1 |
| 7 | Crossover of formic acid through Nafion membranes 显示文摘 | RHEE Y W HA S Y MASEL R I | 2003 | Journal of Power Sources2003，117，12： | 1 |
| 8 | Preparation and characterization of core-shell particles containing perfluoroalkyl acrylate in the shell显示文摘 | Ha J W Park I J Lee S B | 2002 | Macromolecules2002，35，： | 1 |
| 9 | Cue reactivity and effects of exposure in abstinent posttreatment drug users显示文摘 | Ingmar HA Hein A Chris W | 1999 | J Subst Abuse Treat1999，16，： | 1 |
| 10 | Global cerebral ischemic and subsequent selective hypothermia显示文摘 | Horn M Schlote W Henrich HA | 1991 | Acta Neunpathol1991，81，： | 1 |
| 11 | Crossover of formic acid through Nation membranes 显示文摘 | Rhee Y W Ha S Y Masel R I | 2003 | Journal of Power Sources2003，117，12： | 1 |
| 12 | Dissolution of Bombyx mori silk fibroin in the calcium nitrate tetrahydrate-methanol system and aspects of wet spinning of fibroin solution 显示文摘 | Ha S W Park Y H Hudson S M | 2003 | Biomacromolecules2003，4，3： | 1 |
| 13 | MRI for Small Bowel Diseases显示文摘 | Kim K W Ha H K | 2003 | Semin Ultrasound CT MR2003，，5： | 1 |
| 14 | 显示文摘 | Ha S W Park Y H Hudson S M | 2003 | Biomacromolecules2003，4，： | 1 |
| 15 | Cloning and further sequence analysis of the spike gone of attenuated porcine epidemic diarrhea virus DR13 显示文摘 | Park S J Song D S Ha G W | 2007 | Virus Genes2007，35，： | 1 |
| 16 | 2-D acoustic Laplace-domain waveform inversion of marine field data显示文摘 | Ha W Chung W Park E | 2012 | Geophysical Journal International2012，190，1： | 1 |
| 17 | Hypocomplementemic urticarial vasculitis syndrome:an interdisciplinary challenge显示文摘 | Grotz W Babe HA Becker JU | 2009 | Dtsch Arztebl Int2009，106，46： | 1 |
| 18 | A fast BDD algorithm for large coherent fault trees analysis显示文摘 | JUNG W S HANS H HA J | 2004 | Reliability Engineering and System Safety2004，83，3： | 1 |
| 19 | Structural studies of Bombyx mori silk fibroin during regeneration from solutions and wet fiber spinning 显示文摘 | Ha S W Tonelli A E Hudson S M | 2005 | Biomacromolecules2005，6，3： | 1 |
| 20 | Activated platelets induce Weibel-Palade-body secretion and leukocyte rolling in vivo: role of P-selectin 显示文摘 | Dole VS Bergmeier W Mitchell HA | 2005 | Blood2005，106，7： | 1 |
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