| 1 | Improved immunogenicity of a tuberculosis DNA vaccine encoding ESAT6 by DNA priming and protein boosting显示文摘The study evaluated the immune response elicited by a DNA vaccine encoding EbAT6 protein of Mycobacterium tuberculosis by DNA prime-protein boost protocol. BALB/c mice were respectively vaccinated with plasmid DNA encoding ESAT6 protein, with ESAT6 protein in IFA adjuvant, or a combined DNA prime-protein boost regimen. While DNA immunization induced The-polarized immune response, protein-in-adjuvant vaccination elicited a Thz-dominant response. When animals were primed with DNA and boost with protein, both antibodies and Th-cell proliferative response were significantly enhanced. Moreover, production of The-type cytokine (IFN-gamma) was increased significantly by DNA priming-protein boosting. | WangQM SunSH HuZL YinM XiaoCJ ZhangJC | 2005 | 第二军医大学学报2005，26，5： | 1 |
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