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| 1 | Application of poly-lactide-co-glycolide-microspheres in the transarterial chemoembolization in an animal model of hepatocellular carcinoma显示文摘AIM:To introduce an animal model of hepatocellular carcinoma (HCC) in ACI-rats, and to evaluate the therapeutic effects of Poly-lactide-co-glycolide(PIcg)-microspheres in the transarterial chemoembolization (TACE) in this model, as well the value of this model in the experiments of interventional therapy. | Jochen Truebenbach Florian Graepler Philippe Pereira Peter Huppert Thomas Eul Gundula Wiemann Claus Claussen | 2003 | World Journal of Gastroenterology2003，9，1： | 24 |
| 2 | 同种移植大鼠肝细胞癌模型的建立及其磁共振表现显示文摘目的 采取同种移植技术 ,在ACI大鼠建立 1种理想的、适合于介入治疗和MRI观察的肝细胞癌模型。方法 在 1只雄性ACI大鼠背部皮下注射MorrisHepatoma 392 4A肝癌细胞。 13d后从生长的肿瘤中切取 1mm3 瘤块移植到另外的雄性ACI大鼠左肝包膜下 (共 12只 ) ,移植术后 14d利用MRI观察肿瘤体积及其特征 ,并取肿瘤标本做病理切片检查。结果 移植术后 14d时 ,MR检查见所有ACI大鼠肝内均长出孤立性结节状肿瘤 ,不伴有转移和腹水 ,肿瘤平均体积为 (0 .0 90±0 .0 0 8)cm3 。在所有被移植大鼠中 ,病灶在T1WI上呈低信号 ,在T2 WI上呈高信号。病理切片检查示肿瘤内无明显坏死和出血 ,其周围血管丰富。结论 该种建立肝细胞癌动物模型的方法操作简便 ,易于重复 ,移植成功率高 ,肿瘤生长速度适宜 ,无转移和腹水 ,MR检查效果良好 ,尤其适于肝癌介入治疗的研究。 | 钱骏 冯敢生 Truebenbach Jochen Pereira Philippe Huppert Peter Claussen Claus | 2002 | 中华放射学杂志2002，36，5： | 15 |
| 3 | ACI大鼠肝细胞癌模型在介入治疗实验中的初步应用显示文摘目的 评价在ACI大鼠肝细胞癌模型进行多种介入治疗方案的疗效及该模型在介入治疗实验中的应用价值。方法 在 5 8只雄性ACI大鼠肝包膜下植入MorrisHepatoma 3 92 4A肝癌瘤块( 1mm3) ,移植术后 13d行MR检查 ,测量肿瘤体积 (V1) ,第 14天时 ,经腹部切开术及胃十二指肠动脉逆行插管而采取以下介入治疗方案 :(A)丝裂霉素 4只 ;(B)降解淀粉 4只 ;(C)碘油 5只 ;(D)肝动脉结扎 4只 ;(E)丝裂霉素 +降解淀粉 4只 ;(F)丝裂霉素 +动脉结扎 5只 ;(G)丝裂霉素 +碘油 5只 ;(H)降解淀粉 +动脉结扎 4只 ;(I)碘油 +动脉结扎 4只 ;(J)丝裂霉素 +聚丙交酯复合乙交酯 (poly lactid co glycolid ,Plcg)微球 4只 ;(K)丝裂霉素 +碘油 +动脉结扎 4只 ;(L)丝裂霉素 +降解淀粉 +动脉结扎4只 ;(M) 0 9%生理盐水 (对照组 ,7只 )。 13d后再次行磁共振检查以确定肿瘤体积 (V2 )变化 ,并对各组间V2 /V1的比值进行比较。结果 肝癌移植率为 10 0 %。介入治疗后肿瘤体积与治疗前肿瘤体积之比 (V2 /V1)分别为A组 4 5 0 ,B组 12 73 ,C组 15 84,D组 10 17,E组 90 2 0 ,F组 7 16,G组 4 0 8,H组 3 45 ,I组 9 99,J组 2 86,K组 3 76,L组 7 71,M组 2 7 12。与对照组相比 ,采取A、G、H、J和K组方法能明显抑制肿瘤生长 ( χ2 值分别为 5 | 钱骏 Truebenbach Jochen Eul Thomas Graepler Florian Pereira Philippe Huppert Peter 冯敢生 Claussen Claus | 2003 | 中华放射学杂志2003，37，1： | 5 |
| 4 | 聚丙交酯复合乙交酯微球经肝动脉化疗栓塞术治疗肝癌的动物实验显示文摘目的 :在肝细胞癌动物模型上观察聚丙交酯复合乙交酯 (PLcG)微球经肝动脉化疗栓塞术 (TACE)治疗肝癌的疗效。方法 :在雄性ACI大鼠 ( 15例 )肝包膜下植入MorrisHepatoma 392 4A肝癌小瘤块 ( 1mm3) ,移植术后 13天时行磁共振检查。再经正中腹切开术和经胃十二指肠动脉逆行插管进行以下介入治疗 :治疗组A( 40mgPLcG + 0 .0 5mg丝裂霉素 ,4例 )、对照组B( 0 .0 5mg丝裂霉素 + 0 .0 4mg碘化油 +肝动脉结扎 ,4例 )和对照组C( 1.5ml生理盐水 ,7例 )。插管术后 13天再次行磁共振术观察肝肿瘤体积变化。结果 :在C组 ,肿瘤体积在实验期间增长 2 7.12倍 ,在B组 ,肿瘤体积增长 3.76倍 ,而在A组 ,肿瘤体积仅增长 2 .87倍。A组与C组肿瘤体积增长率在t检验时均有显著性差异 (P <0 .0 5 )。结论 :在动物实验中将PLcG微球运用于TACE可明显抑制肝肿瘤生长。 | 钱骏 冯敢生 TruebenbachJ Pereira PL Huppert PE Graepler F Eul T Claussen CD | 2001 | 放射学实践2001，16，6： | 4 |
| 5 | Ipsilateral breast tumor recurrence in early stage breast cancer patients treated with breast conserving surgery and adjuvant radiation therapy: Concordance of biomarkers and tumor location from primary tumor to in-breast tumor recurrence显示文摘BACKGROUND Patients with an in-breast tumor recurrence(IBTR)after breast-conserving therapy have a high risk of distant metastasis and disease-related mortality.Classifying clinical parameters that increase risk for recurrence after IBTR remains a challenge.AIM To describe primary and recurrent tumor characteristics in patients who experience an IBTR and understand the relationship between these characteristics and disease outcomes.METHODS Patients with stage 0-II breast cancer treated with lumpectomy and adjuvant radiation were identified from institutional databases of patients treated from 2003-2017 at our institution.Overall survival(OS),disease-free survival,and local recurrence-free survival(LRFS)were estimated using the Kaplan Meier method.We identified patients who experienced an isolated IBTR.Concordance of hormone receptor status and location of tumor from primary to recurrence was evaluated.The effect of clinical and treatment parameters on disease outcomes was also evaluated.RESULTS We identified 2164 patients who met the eligibility criteria.The median follow-up for all patients was 3.73[interquartile range(IQR)2.27-6.07]years.Five-year OS was 97.7%(95%CI:96.8%-98.6%)with 28 deaths;5-year LRFS was 98.0%(97.2-98.8)with 31 IBTRs.We identified 37 patients with isolated IBTR,19(51.4%)as ductal carcinoma in situ and 18(48.6%)as invasive disease,of whom 83.3%had an in situ component.Median time from initial diagnosis to IBTR was 1.97(IQR:1.03-3.5)years.Radiotherapy information was available for 30 of 37 patients.Median whole-breast dose was 40.5 Gy and 23 patients received a boost to the tumor bed.Twenty-five of thirty-two(78.1%)patients had concordant hormone receptor status,HER-2 receptor status,and estrogen receptor(ER)(P=0.006)and progesterone receptor(PR)(P=0.001)status from primary to IBTR were significantly associated.There were no observed changes in HER-2 status from primary to IBTR.The concordance between quadrant of primary to IBTR was 10/19[(62.2%),P=0.008].Tumor size greater than 1.5 cm(HR=0.44,95%CI:0.22-0.90,P=0.02)and use of endocrine therapy upfront(HR=0.36,95%CI:0.18-0.73,P=0.004)decreased the risk of IBTR.CONCLUSION Among patients with early stage breast cancer who had breast conserving surgery treated with adjuvant RT,ER/PR status and quadrant were highly concordant from primary to IBTR.Tumor size greater than 1.5 cm and use of adjuvant endocrine therapy were significantly associated with decreased risk of IBTR. | Juhi M Purswani Fauzia Shaikh S Peter Wu Jennifer Chun Kim Freya Schnabel Nelly Huppert Carmen A Perez Naamit K Gerber | 2020 | World Journal of Clinical Oncology2020，11，1： | 2 |
| 6 | Aging and lymphocyte subpopulations: whole blood analysis of immune markers in a large population sample of healthy elderly individuals 显示文摘 | Huppert FA Solomou W O' Connor S | 1998 | Exp Gerontol1998，33，6： | 1 |
| 7 | G-quadruplexes : the begin- ning and end of UTRs 显示文摘 | Huppert JL Bugant A Kumari S | 2008 | Nucleic Acids Res2008，36，19： | 1 |
| 8 | The generation of granitic magmas by intrusion of basalt in to continental crust显示文摘 | Huppert H Sparks T S J | 1988 | Journal of Petrology1988，29，3： | 1 |
| 9 | Molecular profiling of angiogenesis with targeted ultrasound imaging:early assessment of antiangiogenic therapy effects显示文摘 | Palmowski M Huppert J Ladewig G | 2008 | Mol Cancer Ther2008，7，： | 1 |
| 10 | Adhesion of different bifidobacteria strains to human enterocyte-like Caco-2 cells and comparison with in vivo study 显示文摘 | Crociani J Grill J P Huppert M | 1995 | Appl Microbiol1995，21，： | 1 |
| 11 | The Ohsessive-complusive inventory : development and validation of a short version 显示文摘 | Foa EB Huppert JD Leiberg S | 2002 | Psy- cholo Assess2002，14，： | 1 |
| 12 | Axisymmetric particle-driven gravity currents显示文摘 | BONNECAZE R T HALLWORTH M A HUPPERT H E and LISTER J R | 1998 | J Fluid Mech1998，294，： | 1 |
| 13 | The effect of rotation on axisymmetric gravity currents 显示文摘 | UNGARISH M and HUPPERT H E | 1998 | J Fluid Mech1998，362，： | 1 |
| 14 | Rho5p downregulates the yeast cell integrity pathway 显示文摘 | Schmitz H P Huppert S Lorberg A | 2002 | Journal of Cell Science2002，115，15： | 1 |
| 15 | Putative DNA quadru- plex formation within the human c-kit oncogene显示文摘 | Rankin S Reszka AP Huppert J | 2005 | J Am Chem Soc2005，127，10： | 1 |
| 16 | Benign paroxysmal positioning vertigo:along-term follow-up(6-17 years)of 125 patients显示文摘 | Brandt T Huppert D Hecht J | | 0，，： | 1 |
| 17 | Long-term course of Meniere's disease revisited 显示文摘 | Huppert D Strupp M Brandt T | 2010 | Acta Otolaryngol2010，130，6： | 1 |
| 18 | Response versus re- mission in obsessive-compulsive disorder 显示文摘 | Simpson H B Huppert J D Petkova E | 2006 | J Clin Psychiatry2006，67，2： | 1 |
| 19 | The OCI-R:validation of the subscales in a clinical sample 显示文摘 | Huppert J Walther MR Hajcak G | 2007 | J Anxiety Disord2007，21，： | 1 |
| 20 | The slumping of gravity currents显示文摘 | HUPPERT H E and SIMPSON J E | 1980 | J Fluid Mech1980，99，： | 1 |
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