|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Effect of hepatitis C virus infection on expression of several cancer-associated gene products in hepatocellular carcinoma显示文摘NTRODUCTIONOurpreviousstudiesbyseroepidemiological,molecularepidemiologicalandimmunopathologicalmethodshaverevealedthathepa... | YANG Jian Min, WANG Rong Quan, BU Bao Guo, ZHOU Zi Cheng, FANG Dian Chun and LUO Yuan Hui | 1999 | World Journal of Gastroenterology1999，5，1： | 42 |
| 2 | Correlation of Seven Biological Factors(Hsp90α,p53,MDM2,Bcl-2,Bax,Cytochrome C,and Cleaved caspase3)with Clinical Outcomes of ALK+ Anaplastic Large-cell Lymphoma显示文摘Objective To explore correlation of seven apoptosis‐related proteins (Hsp90α,p53,MDM2,Bcl‐2,Bax,Cytochrome C,and Cleaved caspase3) with clinical outcomes of ALK+ anaplastic large‐cell lymphoma (ALCL).Methods Using immunohistochemistry and immunofluorescence double staining methods,the expressions of these seven apoptosis‐associated proteins were studied to clarify their relationship with clinical outcomes of 36 ALK+ and 25 ALK‐ systemic ALCL patients enrolled between 1996 and 2006.The relationship of these apoptosis‐regulating proteins with NPM‐ALK status was also evaluated with the tyrosine inhibitor herbimycin A (HA) in vitro by immunocytochemistry,Western blotting and flow cytometric assays.Results The presence of Hsp90α‐,MDM2‐,Bax‐,Cytochrome C,and Cleaved caspase3‐positive tumor cells was found significantly different in ALK+ and ALK‐ ALCLs ,which was correlated with highly favorable clinical outcome.The Bcl‐2‐ and p53‐positive tumor cells were found in groups of patients with unfavorable prognosis.Inhibition of NPM‐ALK by HA could reactivate the p53 protein and subsequent apoptosis‐related proteins and therefore induced apoptosis in ALK+ ALCL cells.Conclusion Our results suggest that these seven proteins might be involved in apoptosis regulation and associated with clinical outcome of ALK+ systemic ALCLs.We also reveal a dynamic chain relation that NPM‐ALK regulates p53 expression and subsequent apoptosis cascade in ALK+ ALCLs. | LI Hui Ling HUANG Xue Ping ZHOU Xin Hua JI Tian Hai WU Zi Qing WANG Zhi Qiang JIANG Hui Yong LIU Fan Rong ZHAO Tong | 2011 | Biomedical and Environmental Sciences2011，24，6： | 9 |
| 3 | Handgrip Strength as a Predictor of Nutritional Status in Chinese Elderly Inpatients at Hospital Admission显示文摘Objective To assess nutritional status and define gender-and age-specific handgrip strength(HGS) cut-point values for malnutrition or nutritional risk in elderly inpatients. Methods A cross-sectional study of 1,343 elderly inpatients was conducted in the Chinese PLA General Hospital. Nutrition Risk Screening(NRS 2002) and Subjective Global Assessment(SGA) were administered. Anthropometric measurements and blood biochemical indicators were obtained using standard techniques. The gender-and age-specific receiver operating characteristic(ROC) curves were constructed to evaluate the HGS for nutritional status by SGA and NRS 2002. Sensitivity, specificity, and areas under the curves(AUCs) were calculated. Results According to NRS 2002 and SGA, 63.81% of elderly inpatients were at nutritional risk and 28.22% were malnourished. Patients with higher HGS had an independently decreased risk of malnutrition and nutritional risk. The AUCs varied between 0.670 and 0.761. According to NRS 2002, the optimal HGS cut-points were 27.5 kg(65-74 years) and 21.0 kg(75-90 years) for men and 17.0 kg(65-74 years) and 14.6 kg(75-90 years) for women. According to SGA, the optimal HGS cut-points were 24.9 kg(65-74 years) and 20.8 kg(75-90 years) for men and 15.2 kg(65-74 years) and 13.5 kg(75-90 years) for women. Conclusion Elderly inpatients had increased incidence of malnutrition or nutritional risk. HGS cut-points can be used for assessing nutritional status in elderly inpatients at hospital admission in China. | ZHANG Xin Sheng LIU Ying Hua ZHANG Yong XU Qing YU Xiao Ming YANG Xue Yan LIU Zhao LI Hui Zi LI Feng XUE Chang Yong | 2017 | Biomedical and Environmental Sciences2017，30，11： | 9 |
| 4 | Prognostic value of clinical characteristics and immunophenotypic biomarkers in 115 patients with primary central nervous system lymphoma显示文摘 | CHEN Bo-bin XU Xiao-ping SHEN Lin HAN Tian-jie LIN Zhi-guang CHEN Zi KANG Hui HUANG Bo LIN Guo-wei | 2013 | Chinese Medical Journal2013，，3： | 6 |
| 5 | Role of PLC-PIP2 and cAMP-PKA Signal Pathways in Radiation-induced Immune-suppressing Effect显示文摘Objective The purpose of the present study was to observe the changes in CD4+CD25+Nrp1+Treg cells after irradiation with different doses and explore the possible molecular mechanisms involved. Methods ICR mice and mouse lymphoma cell line(EL-4 cells) was used. The expressions of CD4,CD25,Nrp1,calcineurin and PKC-α were detected by flow cytometry. The expressions of TGF-β1,IL-10,PKA and cAMP were estimated with ELISA. Results At 12 h after irradiation,the expression of Nrp1 increased significantly in 4.0 Gy group,compared with sham-irradiation group(P<0.05) in the spleen and thymus,respectively,when ICR mice received whole-body irradiation(WBI). Meanwhile the synthesis of Interleukin 10(IL-10) and transforming growth factor-β1(TGF-β1) increased significantly after high dose irradiation(HDR)(> or = 1.0 Gy). In addition,the expression of cAMP and PKA protein increased,while PKC-α,calcineurin decreased at 12h in thymus cells after 4.0 Gy X-irradiation. While TGF-β1 was clearly inhibited when the PLC-PIP2 signal pathway was stimulated or the cAMP-PKA signal pathway was blocked after 4.0 Gy X-irradiation,this did not limit the up-regulation of CD4+CD25+Nrp1+Treg cells after ionizing radiation. Conclusion These results indicated that HDR might induce CD4+CD25+Nrp1+Treg cells production and stimulate TGF-β1 secretion by regulating signal molecules in mice. | DONG Juan Cong CHENG Guang Hui SHAN Yu Xing WU Ning SHAO Ming Long LI Peng Wu JIN Shun Zi | 2014 | Biomedical and Environmental Sciences2014，27，1： | 5 |
| 6 | Exposure Effects of Terahertz Waves on Primary Neurons and Neuron-like Cells Under Nonthermal Conditions显示文摘Objective This study aimed to explore the potential effects of terahertz(THz) waves on primary cultured neurons from 4 rat brain regions(hippocampus, cerebral cortex, cerebellum, and brainstem)and 3 kinds of neuron-like cells(MN9 D, PC12, and HT22 cells) under nonthermal conditions.Methods THz waves with an output power of 50(0.16 THz) and 10(0.17 THz) m W with exposure times of 6 and 60 min were used in this study. Analysis of temperature change, neurite growth, cell membrane roughness, micromorphology, neurotransmitters and synaptic-related proteins(SYN and PSD95) was used to evaluate the potential effects.Results Temperature increase caused by the THz wave was negligible. THz waves induced significant neurotransmitter changes in primary hippocampal, cerebellar, and brainstem neurons and in MN9 D and PC12 cells. THz wave downregulated SYN expression in primary hippocampal neurons and downregulated PSD95 expression in primary cortical neurons.Conclusion Different types of cells responded differently after THz wave exposure, and primary hippocampal and cortical neurons and MN9 D cells were relatively sensitive to the THz waves. The biological effects were positively correlated with the exposure time of the THz waves. | TAN Sheng Zhi TAN Peng Cheng LUO Lan Qing CHI Yun Liang YANG Zi Long ZHAO Xue Long ZHAO Li DONG Ji ZHANG Jing YAO Bin Wei XU Xin Ping TIAN Guang CHEN Jian Kui WANG Hui PENG Rui Yun | 2019 | Biomedical and Environmental Sciences2019，32，10： | 5 |
| 7 | Attractor for Lattice System of Dissipative Zakharov Equation显示文摘我们认为一个无限的格子的解决方案的 asymptotic 行为是消散的 Zakharov 方程的动态系统。由介绍在空格和建立的制服的内部产品和标准在“解决方案的尾巴结束”估计的新重量,我们克服 Sobolev 协议在无限的格子系统下面嵌入的缺乏引起的一些困难,并且证明全球引起注意的人的存在;然后由在有限维的空间使用元素分解和一个多面体的盖住的性质,我们为全球引起注意的人的 Kolmogorov ɛ-entropy 获得上面的界限;最后,我们在场全球引起注意的人的上面的半连续性。 | Fu Qi YIN Sheng Fan ZHOU Zi Gen OUYANG Cui Hui XIAO | 2009 | Acta Mathematica Sinica,English Series2009，25，2： | 4 |
| 8 | Multi-channel phasemeter and its application in the heterodyne laser interferometry显示文摘The mission to detect gravitational wave in space requires a not only sophisticated but also ultra-precise laser interferometric measurement system.Within a single spacecraft,tens of interferometric beat signals are generated at the same time and they also need to be processed simultaneously.In this paper,a multi-channel phasemeter which can parallelly process the signals is constructed.The test shows that a sensitivity of 2Π rad/√Hz could be achieved in the frequency range of 0.1 to 10 Hz.We also utilize the phasemeter to evaluate the performance of a heterodyne laser interferometer. | LIU He Shan DONG Yu Hui LUO Zi Ren LI Yu Qiong JIN Gang | 2015 | Science China(Technological Sciences)2015，58，4： | 4 |
| 9 | A NOVEL STEROID FROM EICHHORNIA CRASSIPES显示文摘6(?)-Hydroxy-stigmasta-4,22-diene-3-one 1,a novel steroid,was isolated from the Eichhornia Crassipes.Its structure was deter-mined by 1H and 13C NMR spectroscopy and further confirmed by authen-tic sample,which was synthesized from stigmasterol 2. | Hou Ming WU Hui Qiang ZHOU Sheng yu HUANG Kan MA Xia Fei LAO State Key Laboratory of Bio-organic and Natural Products Chemistry Shanghai Institute of Organic Chemistry,Academia Sinica 345 LingLing Lu,Shanghai 200032Shu Wen YU Wen Hao SUN Zi Wen YU Shanghai Institute of Plant Physiology Academia Sinica,Shanghai 200032 | 1991 | Chinese Chemical Letters1991，2，7： | 3 |
| 10 | Probing cytotoxicity of CdSe and CdSe/CdS quantum dots显示文摘CdSe 和 CdSe/CdS 量点(QD ) 的毒性由帮助超声的方法综合了在 vitro 并且在 vivo 被调查。五根人的房间线被用来由 MTT 生存能力,红血房间溶血,流动 cytometry,和荧光成像的试金估计同样准备的 CdSe 和 CdSe/CdS 的 cytotoxicity。结果证明这些 QD 可能由他们在在房间周期的 S 和 G2 阶段的影响是细胞毒素的。QD 的 cytotoxicity 两个都取决于物理化学的性质并且与目标房间有关。 | Yan Jie Bao Jun Jun Li Yi Ting Wang Lei Yu Lei Lou Wei Ji Du Zi Qiang Zhu Hui Peng Jian Zhong Zhu | 2011 | Chinese Chemical Letters2011，22，7： | 2 |
| 11 | Preparation and chiral recognitio of a novel chiral stationary phase for HPLC,based on mono(6~A-N-1-(2-hydroxyl)-phenylethylimino-6~A-deoxy)-β-cyclodextrin and covalently bonded silica gel显示文摘新奇 chiral 静止阶段(CSP ) 被使不能调动准备单音(6A-N-1-(2 氢氧根)-phenylethyl-imino-6A-deoxy)- 尾 -cyclodextrin 到经由一个更长的分隔符的硅石胶化的表面上。这 chiral 静止阶段在反向阶段的条件下面为许多 chiral 混合物展出了好 enantioselectivity。 | Xiao Ping Chen Zhi Ming Zhou Hao Yuan Zi Hui Meng | 2008 | Chinese Chemical Letters2008，19，7： | 2 |
| 12 | Clinical Practice Guideline of Acupuncture for Bell's Palsy显示文摘Backgroud: Acupuncture is common used for Bell's palsy in clinic, however, recent systematic reviews all shows that there is no sufficient evidence to support the effectiveness of acupuncture for Bell's palsy because ofthe poor quality and heterogeneity. It's urgently necessary to develop a guideline of acupuncture for Bell's palsy based on principles of evidence-based medicine to optimize acupuncture treating,standardize outcomes evaluating and to improve the quality of acupuncture for patients with Bell's palsy under general circumstances.Objective: To improve the accuracy of diagnosing and managing Bell's palsy, optimize acupuncture treating and outcomes evaluating for patients with Bell's palsy, and to improve the quality of acupuncture for patients with Bell's palsy in most instances.Methods: This guideline was developed using an explicit and transparent a priori protocol based on supporting evidences and experts' consensus. The guideline developing Group followed the protocol through all stages of the development process: proposed clinical questions,searched clinical evidences, evaluated levels of evidences, developed recommendations, peer reviewed and consummated, and finally formed the draft of this guideline.Results:(1)The guideline development group made a Grade A recommendation that ①With a course of Bell's palsy within 3 months, the patients with mild facial palsy may be treated with any one of acupuncture, western drugs, or acupuncture combing with western drugs,whereas the patients with severe facial palsy may be treated with acupuncture or acupuncture combing with western drugs. With a course of more than 3 months, acupuncture is more suitable.②Acupuncture should be applied as early as possible for Bell's palsy.③The principle of selecting acupoints for Bell's palsy is to select local points, points of corresponding meridians and those according to differentiation. Generally,the points of yangming meridians are the main ones. ④The various methods of acupuncture and moxibustion are adopted for Bell's palsy,including filiform needling, moxibustion, electro-acupuncture, etc. Two or more methods are usually used together in clinical practice.(2) The development group formed expert consensus on the principles of acupuncture treatment for Bell' palsy. Bell's palsy is suitably treated according to the stages, differentiation and symptoms. | Xi Wu Ying Li Yi-Hui Zhu Hui Zheng Qin Chen Xue-Zhi Li Ling Luo Fang Zeng Wen-Jing Huang Ling Zhao Xiao-Dong Wu Hong Zhao Ming-Jie Zi Xu Guo Si-Yuan Zhou Hui-Juan Tan Fan-Rong Liang | 2015 | World Journal of Traditional Chinese Medicine2015，1，4： | 2 |
| 13 | A new nor-sesquiterpene lactone from Ainsliaea fulvioides显示文摘新 nor-sesquiterpene 内酯 ainsliatone A (1 ) 从 Ainsliaea fulvioides 的天线部分被孤立。它的结构被分光镜的方法和单个水晶的 X 光检查衍射分析的基础建立。 | Yan Wang Ming Lu Xu Hui Zi Jin Jian Jun Fu Xiao Jia Hu Jiang Jiang Qin Shi Kai Yan Yun Heng Shen Wei Dong Zhang | 2009 | Chinese Chemical Letters2009，20，5： | 2 |
| 14 | Cis-2-dodecenoic Acid Mediates Its Synergistic Effect with Triazoles by Interfering with Efflux Pumps in Fluconazole-resistant Candida albicans显示文摘Objective To evaluate the synergy of the Burkholderia signaling molecule cis-2-dodecenoic acid(BDSF) and fluconazole(FLU) or itraconazole(ITRA) against two azole-resistant C. albicans clinical isolates in vitro and in vivo. Methods Minimum inhibitory concentrations(MICs) of antibiotics against two azole-resistant C. albicans were measured by the checkerboard technique, E-test, and time-kill assay. In vivo antifungal synergy testing was performed on mice. Analysis of the relative gene expression levels of the strains was conducted by quantitative reverse-transcription polymerase chain reaction(qR T-PCR). Results BDSF showed highly synergistic effects in combination with FLU or ITRA with a fractional inhibitory concentration index of ≤ 0.08. BDSF was not cytotoxic to normal human foreskin fibroblast cells at concentrations of up to 300 μg/mL. The qR T-PCR results showed that the combination of BDSF and FLU/ITRA significantly inhibits the expression of the efflux pump genes CDR1 and MDR1 via suppression of the transcription factors TAC1 and MRR1, respectively, when compared with FLU or ITRA alone. No dramatic difference in the mR NA expression levels of ERG1, ERG11, and UPC2 was found, which indicates that the drug combinations do not significantly interfere with UPC2-mediated ergosterol levels. In vivo experiments revealed that combination therapy can be an effective therapeutic approach to treat candidiasis. Conclusion The synergistic effects of BDSF and azoles may be useful as an alternative approach to control azole-resistant Candida infections. | YANG Dong Liang HU Yan Ling YIN Zi Xin ZENG Gui Sheng LI Dan ZHANG Yu Qian XU Zhen Hua GUAN Xiao Ming WENG Li Xing WANG Lian Hui | 2019 | Biomedical and Environmental Sciences2019，32，3： | 2 |
| 15 | Integrated emergency department and general intensive care unit management on health outcomes显示文摘The emergency department(ED)should reliably provide the required medical treatment to patients who are in an emergency or are critically ill.However,the ED faced two challenges in China. | Shan-Lin Mao Zi Ge Hui Zhao Yan-Xue Wang Jun Cao Zhi-Jie Xia | 2021 | Chinese Medical Journal2021，，21： | 2 |
| 16 | Anthranilic acid derivatives from Inula japonica显示文摘三新 anthranilic 衍生物, N-heneicosanoylanthranilic 酸(1b ) 和 N-docosanoylanthranilic 酸(1c ) 从 Inula 装饰用的梨树 Thunb 的天线部分被孤立。他们的结构被分光镜、化学的方法建立。 | Jiang Jiang Qin Hui Zi Jin Jian Jun Fu Xiao Jia Hu Yan Zhu Yun Heng Shen Shi Kai Yan Wei Dong Zhang | 2008 | Chinese Chemical Letters2008，19，5： | 2 |
| 17 | Amination of electron deficient aryl chlorides promoted by nano sized Mg(OH)_2 under transition metals free condition显示文摘这份报纸论述缺乏的芳基氯化物由 Mg 支持了的电子的胺化作用反应(哦) 2 没有转变金属。仅仅用 stoichiometric, nano 的数量缩放 Mg (哦) 2,对中等孤立的收益好能在 150 在 24 h 以后在 N-methylpyrrolidone (NMP ) | Zhi Hao Cui Zi Hui Meng Yan Qing Mi Peng Wang Qi Wang Lin Man Zhao Ke Jian Cui Fang Yu Zhi Bin Xu | 2012 | Chinese Chemical Letters2012，23，2： | 2 |
| 18 | Effect of muscarinic blocker on enhancing action of fructus aurantilii immaturus in the intestinal myoelectric activity in dogs显示文摘Subjectheadingsfurctusaurantiimmaturus;smalintestine;atropine;electrophysiologyAbstractAIMToinvestigatetheefectofFructusAuran... | HUANG Zi He 1, YANG De Zhi 2, WEI Yi Quan 2 and LUO Yin Hui 1 | 1997 | World Journal of Gastroenterology1997，3，2： | 2 |
| 19 | Different mechanisms of improving CH_(3)NH_(3)PbI_(3) perovskite solar cells brought by fluorinated or nitrogen doped graphdiyne显示文摘Fluorinated and nitrogen-doped graphdiyne(F/N-GDY)have been used in the active layer of perovskite solar cells(PSCs)for the first time.The introduction of heteroatoms turns out to be an effective method for boosted solar cells performance,which increases by 32.8%and 33.0%,better than the pristine or GDY doped PSCs.The enhanced performance can be attributed firstly to the superiority of F/N-GDY originated from the unique structure and optoelectronic properties of GDY.Then,both can further reduce surface defects and improve surface and bulk crystallinity than pristine GDY.What's more,efficiency increase caused by F-GDY is mainly attributed to the improvement of fill factor(FF),while the higher short-circuit current(Jsc)plays more important role by N-GDY doping.Most importantly,the detailed mechanism brought about by doping of F-GDY or N-GDY is expounded by systematical characterizations,especially the synchrotron radiation technique.Doping of F-GDY causes Pb and forms new Pb-F bonds between F-GDY and Pb ions.Doping of N-GDY or GDY brings about Pb(N-GDY doping induces more deviation than that of GDY due to the participation of imine N),improving its electron density and conductivity. | Huan Huang Bing Liu Dan Wang Rongli Cui Xihong Guo Ying Li Shouwei Zuo Zi Yin Huanhua Wang Jing Zhang Hui Yuan Lirong Zheng Baoyun Sun | 2022 | Nano Research2022，15，1： | 2 |
| 20 | Robust stability for stochastic Hopfield neural networks with time delays显示文摘 | Wang Zi Dong Shu Hui Sheng Fang Jian An | 2006 | Nonlinear Analysis: Real World Applications2006，7，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员