|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Device-associated infection rates, mortality, length of stay and bacterial resistance in intensive care units in Ecuador: International Nosocomial Infection Control Consortium's findings显示文摘AIM To report the results of the International Nosocomial Infection Control Consortium(INICC) study conducted in Quito, Ecuador.METHODS A device-associated healthcare-acquired infection(DAHAI) prospective surveillance study conducted from October 2013 to January 2015 in 2 adult intensive care units(ICUs) from 2 hospitals using the United States Centers for Disease Control/National Healthcare Safety Network(CDC/NHSN) definitions and INICC methods. RESULTS We followed 776 ICU patients for 4818 bed-days. The central line-associated bloodstream infection(CLABSI) rate was 6.5 per 1000 central line(CL)-days, the ventilator-associated pneumonia(VAP) rate was 44.3 per 1000 mechanical ventilator(MV)-days, and the catheterassociated urinary tract infection(CAUTI) rate was 5.7 per 1000 urinary catheter(UC)-days. CLABSI and CAUTI rates in our ICUs were similar to INICC rates [4.9(CLABSI) and 5.3(CAUTI)] and higher than NHSN rates [0.8(CLABSI) and 1.3(CAUTI)]- although device use ratios for CL and UC were higher than INICC and CDC/NSHN's ratios. By contrast, despite the VAP rate was higher than INICC(16.5) and NHSN's rates(1.1), MV DUR was lower in our ICUs. Resistance of A. baumannii to imipenem and meropenem was 75.0%, and of Pseudomonas aeruginosa to ciprofloxacin and piperacillin-tazobactam was higher than 72.7%, all them higher than CDC/NHSN rates. Excess length of stay was 7.4 d for patients with CLABSI, 4.8 for patients with VAP and 9.2 for patients CAUTI. Excess crude mortality in ICUs was 30.9% for CLABSI, 14.5% for VAP and 17.6% for CAUTI. CONCLUSION DA-HAI rates in our ICUs from Ecuador are higher than United States CDC/NSHN rates and similar to INICC international rates. | Estuardo Salgado Yepez Maria M Bovera Victor D Rosenthal Hugo A González Flores Leonardo Pazmino Francisco Valencia Nelly Alquinga Vanessa Ramirez Edgar Jara Miguel Lascano Veronica Delgado Cristian Cevallos Gasdali Santacruz Cristian Pelaéz Celso Zaruma Diego Barahona Pinto | 2017 | World Journal of Biological Chemistry2017，8，1： | 23 |
| 2 | Role of IL-10 and TGF-β1 in local immunosuppression in HPV-associated cervical neoplasia显示文摘Cervical cancer is a worldwide disease that constitutes a significant public health problem, especially in developing countries, not only due to its high incidence but also because the most affected population comprises women who belong to marginalized socio-economic classes. Clinical and molecular research has identified immunological impairment in squamous intraepithelial cervical lesions and cervical cancer patients. Human Papillomavirus(HPV) has several mechanisms for avoiding the immune system: it down-regulates the expression of interferon and upregulates interleukin(IL)-10and transforming growth factor(TGF)-β1 to produce a local immunosuppressive environment, which, along with altered tumor surface antigens, forms an immunosuppressive network that inhibits the antitumor immune response. In this review we analyzed the available data on several deregulated cellular immune functions in patients with NIC Ⅰ, NIC Ⅱ and NIC Ⅲ and cervical cancer. The effects of immunosuppressive cytokines on innate immune response, T-cell activation and cellular factors that promote tumor cell proliferation in cervical cancer patients are summarized. We discuss the functional consequences of HPV E2, E6, and E7 protein interactions with IL-10 and TGF-β1 promoters in the induction of these cytokines and postulate its effect on the cellular immune response in squamous intraepithelial cervical lesions and cervical cancer patients. This review provides a comprehensive picture of the immunological functions of IL-10 and TGF-β1 in response to HPV in humans. | Kirvis Torres-Poveda Margarita Bahena-Román Claudia Madrid-González Ana I Burguete-García Víctor Hugo Bermúdez-Morales Oscar Peralta-Zaragoza Vicente Madrid-Marina | 2014 | World Journal of Clinical Oncology2014，5，4： | 21 |
| 3 | Advances in InGaAs/InP single-photon detector systems for quantum communication显示文摘Single-photon detectors(SPDs)are the most sensitive instruments for light detection.In the near-infrared range,SPDs based on III–V compound semiconductor avalanche photodiodes have been extensively used during the past two decades for diverse applications due to their advantages in practicality including small size,low cost and easy operation.In the past decade,the rapid developments and increasing demands in quantum information science have served as key drivers to improve the device performance of single-photon avalanche diodes and to invent new avalanche quenching techniques.This Review aims to introduce the technology advances of InGaAs/InP single-photon detector systems in the telecom wavelengths and the relevant quantum communication applications,and particularly to highlight recent emerging techniques such as high-frequency gating at GHz rates and free-running operation using negative-feedback avalanche diodes.Future perspectives of both the devices and quenching techniques are summarized. | Jun Zhang Mark A Itzler Hugo Zbinden Jian-Wei Pan | 2015 | Light(Science & Applications)2015，4，1： | 21 |
| 4 | 现代夯土墙体施工技术研究与实践显示文摘传统夯土建筑是指以木制或石制杵、锤等工具,将原状土质材料逐层夯实形成承重墙体的建筑。现代夯土建筑技术对传统夯土建筑中夯筑材料、夯筑机具、夯筑工艺等方面进行了改良,以提高夯土房屋的安全性与耐久性。在国际生土建筑研究和应用中心的指导下,结合试点工程的研究与实践,重点对如何科学选择、配置夯土材料及墙体夯筑工艺的改良情况做了说明。 | 周铁钢 彭道强 穆钧 Hugo Charly Gasnier Quentin Arya Romain Chansavang | 2012 | 施工技术2012，41，8： | 20 |
| 5 | -765G > C COX-2 polymorphism may be a susceptibility marker for gastric adenocarcinoma in patients with atrophy or intestinal metaplasia显示文摘AIM: To investigate the relationship between the -765G > C COX-2 polymorphism and the development of different gastric lesions: atrophy or intestinal metaplasia and gastric adenocarcinoma. METHODS: A cross-sectional study was performed involving 320 Portuguese individuals (210 without evidence of neoplastic disease, 73 patients with gastric adenocarcinomas and 37 with atrophy or intestinal metaplasia) using a PCR-RFLP method. RESULTS: -765C allele was overrepresented in the patients with gastric adenocarcinoma (51%) when compared either with the control group (38%) or patients with atrophy or intestinal metaplasia (27%). Callele was found to be very common in our population (0.22), and a multivariate logistic regression analysis revealed nearly 3-fold increased risk for the progression to gastric adenocarcinoma in patients with atrophy or intestinal metaplasia carrying the -765C allele (OR = 2.67, 95% CI = 1.03-6.93; P = 0.04).considered as another susceptibility marker for gastric adenocarcinoma development in patients with atrophy or intestinal metaplasia. | Carina Pereira Hugo Sousa Paula Ferreira Maria Fragoso Luís Moreira-Dias Carlos Lopes Rui Medeiros Mário Dinis-Ribeiro | 2006 | World Journal of Gastroenterology2006，12，34： | 16 |
| 6 | Cytokines,cytokine gene polymorphisms and Helicobacter pylori infection:Friend or foe?显示文摘Helicobacter pylori(H.pylori)is a flagellated,spiralshaped,microaerophilic Gram-negative bacillus that colonises the gastric mucosa of more than 50%of the human population.Infection is a risk factor for gastritis,ulcer disease and stomach cancer.Immunity against H.pylori is mainly related to Th1/Th17 skewing,and the activation of regulatory T cells is the main strategy used to limit inflammatory responses,which can result in the pathogen persistence and can lead to chronic gastrointestinal diseases,including cancer.Furthermore,host genetic factors that affect cytokines may determine differences in the susceptibility to many diseases.In this review,we present the cytokine profiles and the main cytokine gene polymorphisms associated with resistance/susceptibility to H.pylori and discuss how such polymorphisms may influence infection/disease outcomes. | Camila A Figueiredo Cintia Rodrigues Marques Ryan dos Santos Costa Hugo Bernardino F da Silva Neuza M Alcantara-Neves | 2014 | World Journal of Gastroenterology2014，20，18： | 11 |
| 7 | Clinical and pathological characterization of epstein-barr virus-associated gastric carcinomas in portugal显示文摘AIM To determine the prevalence of epstein-barr virus(eb V)-associated gastric carcinomas in the North Region of Portugal and to study its clinicopathological characteristics. METHODS We have performed a retrospective study including a total of 179 consecutive patients with gastric cancer(GC) submitted to gastrectomy during 2011 at the Portuguese Oncology Institute of Porto. Clinical and pathological data was collected from individual clinical records and inserted on a database with unique codification. Tumour tissues were collected from the institutional tumour bank. eb V was detected by in situ hybridization for the detection of eb V-encoded small RNAs(ebe Rs) and eb V latent proteins(LMP1 and LMP2 A) were detected by immunohistochemistry.RESULTS The analysis showed that eb V-associated gastric carcinomas(eb Va GC) represents 8.4%(15/179) of all GC cases, with a significant differential distribution among histological types(P < 0.001): 100%(3/3) of medullary carcinomas, 100%(1/1) of adenosquamous carcinoma, 8.7%(8/92) of tubular adenocarcinomas, 8.0%(2/25) of mixed carcinomas and 2%(1/51) in poorly cohesive carcinomas. The analysis revealed a higher predominance of eb Va GC in the upper third and middle(cardia, fundus and body) of the stomach(P = 0.041), a significant lower number of regional lymph nodes invasion(P = 0.025) and a tendency for better prognosis(P = 0.222). eb V latent protein expression revealed that all eb Va GC cases were LMP1-negative, nevertheless 6 cases(40%) expressed LPM2 A, which reveals that these cases show a distinct eb V-Latency profile(latency II-like).CONCLUSION eb Va GC represents 8.4% of all GC in the North Region of Portugal. The eb V-infected patients have specific clinic-pathological features that should be further explored to develop new strategies of management and treatment. | Joana Ribeiro Andreia Oliveira Mariana Malta Claudia Oliveira Fernanda Silva Ana Galaghar Luís Pedro Afonso Maria Cassiano Neves Rui Medeiros Pedro Pimentel-Nunes Hugo Sousa | 2017 | World Journal of Gastroenterology2017，23，40： | 9 |
| 8 | 多发性脑膜瘤的临床和组织学特点显示文摘 | 黄红光 詹仁雅 R Buhl H H Hugo H M Mehdorn | 2005 | 中华神经外科杂志2005，21，8： | 8 |
| 9 | A phylogenetic and taxonomic re-evaluation of the Bipolaris - Cochliobolus - Curvularia Complex显示文摘Three genera,Cochliobolus,Bipolaris and Curvularia form a complex that contains many plant pathogens,mostly on grasses(Poaceae)with a worldwide distribution.The taxonomy of this complex is confusing as frequent nomenclatural changes and refinements have occurred.There is no clear morphological boundary between the asexual genera Bipolaris and Curvularia,and some species show intermediate morphology.We investigated this complex based on a set of ex-type cultures and collections from northern Thailand.Combined gene analysis of rDNA ITS(internal transcribed spacer),GPDH(glyceraldehyde 3-phosphate dehydrogenase),LSU(large subunit)and EF1-α(translation elongation factor 1-α)shows that this generic complex divides into two groups.Bipolaris and Cochliobolus species clustered in Group 1 along with their type species,whereas Curvularia species(including species named as Bipolaris,Cochliobolus and Curvularia)clustered in Group 2,with its generic type.The nomenclatural conflict in this complex is resolved giving priority to the more commonly used established generic names Bipolaris and Curvularia.Modern descriptions of the genera Bipolaris and Curvularia are provided and species resolved in this study are transferred to one of these genera based on their phylogeny. | Dimuthu S.Manamgoda Lei Cai Eric H.C.McKenzie Pedro W.Crous Hugo Madrid Ekachai Chukeatirote Roger G.Shivas Yu Pei Tan Kevin D.Hyde | 2012 | Fungal Diversity2012，，5： | 7 |
| 10 | The Muruntau gold deposit(Uzbekistan)--A unique ancient hydrothermal system in the southern Tien Shan显示文摘The Muruntau gold deposit in the Central Kyzylkum,Uzbekistan is one of the largest single gold deposits worldwide.Data available from the literature are reviewed with the aim to(1) integrate the present knowledge on this unique deposit from Russian and English literature;(2) show the considerable progress made in the understanding of the genesis of the Muruntau deposit during the last decades;and(3) point to problems still open for future research.Deposit formation occurred through a multi-stage process involving sedimentation,regional metamorphism including thrusting,magmatism with formation of hornfels aureoles and several stages of hydrothermal activity.According to recent knowledge,synsedimentary or pure metamorphic formation of gold mineralization seems unlikely.The role of granite magmatism occurring roughly within the same time interval as the main hydrothermal gold precipitation remains uncertain.There are no signs of interaction of matter between the magma(s) and the hydrothermal system(s).On the other hand,there was an intense,high-temperature(above 400 ℃)fluid- wall rock interaction resulting in the formation of gold-bearing,cone-like stockworks with veins,veinlets and gold-bearing metasomatites.Several chemical and isotope indicators hint at an involvement of lower-crustal or mantle-related sources as well as of surface waters in ore formation.Deposit formation through brecciation involving explosion,hydrothermal or tectonic breccias might explain these data.Further investigations on breccia formation as well as on the exact timing of relevant sedimentary,metamorphic,magmatic and hydrothermal events are recommended. | Ulf Kempe Torsten Graupner Reimar Seltmann Hugo de Boorder Alla Dolgopolova Maarten Zeylmans van Emmichoven | 2016 | Geoscience Frontiers2016，7，3： | 7 |
| 11 | m TOR signaling in liver regeneration: Rapamycin combined with growth factor treatment显示文摘AIM: To investigate the effects of mammalian target of rapamycin(mT OR) inhibition on liver regeneration and autophagy in a surgical resection model.METHODS: C57BL/6 mice were subjected to a 70% partial hepatectomy(PH) and treated intraperitoneally every 24 h with a combination of the m TOR inhibitor rapamycin(2.5 mg/kg per day) and the steroid dexamethasone(2.0 mg/kg per day) in phosphate bufferedsaline(PBS) or with PBS alone as vehicle control. In the immunosuppressant group, part of the group was treated subcutaneously 4 h prior to and 24 h after PH with a combination of human recombinant interleukin 6(IL-6; 500 μg/kg per day) and hepatocyte growth factor(HGF; 100 μg/kg per day) in PBS. Animals were sacrificed 2, 3 or 5 d after PH and liver tissue and blood were collected for further analysis. Immunohistochemical staining for 5-Bromo-2'-deoxyuridine(Brd U) was used to quantify hepatocyte proliferation. Western blotting was used to detect hepatic microtubule-associated protein 1 light chain 3(LC3)-Ⅱ protein expression as a marker for autophagy. Hepatic gene expression levels of proliferation-, inflammation- and angiogenesisrelated genes were examined by real-time reverse transcription-polymerase chain reaction and serum bilirubin and transaminase levels were analyzed at the clinical chemical core facility of the Erasmus MC-University Medical Center.RESULTS: m TOR inhibition significantly suppressed regeneration, shown by decreased hepatocyte proliferation(2% vs 12% Brd U positive hepatocyte nuclei at day 2, P < 0.01; 0.8% vs 1.4% at day 5, P = 0.02) and liver weight reconstitution(63% vs 76% of initial total liver weight at day 3, P = 0.04), and furthermore increased serum transaminase levels(aspartate aminotransferase 641 U/L vs 185 U/L at day 2, P = 0.02). Expression of the autophagy marker LC3-Ⅱ, which was reduced during normal liver regeneration, increased after mT OR inhibition(46% increase at day 2, P = 0.04). Hepatic gene expression showed an increased inflammation-related response [tumor necrosis factor(TNF)-α 3.2-fold upregulation at day 2, P = 0.03; IL-1Ra 6.0-fold upregulation at day 2 and 42.3-fold upregulation at day 5, P < 0.01] and a reduced expression of cell cycle progression and angiogenesis-related factors(HGF 40% reduction at day 2; vascular endothelial growth factor receptor 2 50% reduction at days 2 and 5; angiopoietin 1 60% reduction at day 2, all P ≤ 0.01). Treatmentwith the regeneration stimulating cytokine IL-6 and growth factor HGF could overcome the inhibitory effect on liver weight(75% of initial total liver weight at day 3, P = 0.02 vs immunosuppression alone and P = 0.90 vs controls) and partially reversed gene expression changes caused by rapamycin(TNF-α and IL-1Ra levels at day 2 were restored to control levels). However, no significant changes in hepatocyte proliferation, serum injury markers or autophagy were found.CONCLUSION: mT OR inhibition severely impairs liver regeneration and increases autophagy after PH. These effects are partly reversed by stimulation of the IL-6 and HGF pathways. | Suomi MG Fouraschen Petra E de Ruiter Jaap Kwekkeboom Ron WF de Bruin Geert Kazemier Herold J Metselaar Hugo W Tilanus Luc JW van der Laan Jeroen de Jonge | 2013 | World Journal of Transplantation2013，3，3： | 6 |
| 12 | 增殖性抗原Ki-67、增殖细胞核抗原、Ki-S1在幕上星形细胞瘤的诊断价值比较显示文摘增殖性抗原Ki-67、增殖细胞核抗原、Ki-S1在幕上星形细胞瘤的诊断价值比较傅伟明Heinz-HermannHugo正确判断颅内星形细胞瘤的性质是提高临床疗效,延长患者生存期的关键之一。1993年WHO制定星形细胞瘤分级标准的目的就在于通过形态学的... | 傅伟明 Hugo,H-H | 1997 | 中华病理学杂志1997，26，3： | 6 |
| 13 | Gastric cancer in a Caucasian population: Role of pepsinogen C genetic variants显示文摘瞄准:在胃蛋白酶原 C (PGC ) 基因学习插入 / 删除多型性的角色,为胃粘膜的终端区别的一个有效标记,在到胃的损害的开发的危险性。方法:没有肿瘤的疾病的证据,学习与已知的胃的损害的 99 件样品和 127 件样品被执行。PCR 被采用, 6 多态的等位基因被放大:等位基因 1 (510 bp ) ,等位基因 2 (480 bp ) ,等位基因 3/4 (450/460 bp ) ,等位基因 5 (400 bp ) 并且等位基因 6 (310 bp ) 。结果:我们的结果表明等位基因 6 搬运人似乎对任何胃的损害的发展有保护(或 = 0.34;P<0.001 ) ,与象萎缩或肠的组织变形那样的胃的腺癌联系的 non-dysplastic 损害(或 = 0.28;P<0.001 ) 或侵略 GC (或 = 0.39;P = 0.004 ) 。结论:我们的学习表明等位基因 6 搬运人地位在胃的损害的发展有一个保护的角色,可能由于它有 PGC 的更高的表示的协会。而且,在控制组的等位基因 6 搬运人的频率比在亚洲人口获得了高是远的,它可能代表在白种人和亚洲人口之间的基因差距。 | Ana L Pinto-Correia Hugo Sousa Maria Fragoso Luís Moreira-Dias Carlos Lopes Rui Medeiros Mário Dinis-Ribeiro | 2006 | World Journal of Gastroenterology2006，12，31： | 6 |
| 14 | Cooperative interactions between nano-antennas in a high-Q cavity for unidirectional light sources显示文摘We analyse the resonant mode structure and local density of states in high-Q hybrid plasmonic-photonic resonators composed of dielectric microdisks hybridized with pairs of plasmon antennas that are systematically swept in position through the cavity mode.On the one hand,this system is a classical realization of the cooperative resonant dipole–dipole interaction through a cavity mode,as is evident through predicted and measured resonance linewidths and shifts.At the same time,our work introduces the notion of‘phased array’antenna physics into plasmonic-photonic resonators.We predict that one may construct large local density of states(LDOS)enhancements exceeding those given by a single antenna,which are‘chiral’in the sense of correlating with the unidirectional injection of fluorescence into the cavity.We report an experiment probing the resonances of silicon nitride microdisks decorated with aluminium antenna dimers.Measurements directly confirm the predicted cooperative effects of the coupled dipole antennas as a function of the antenna spacing on the hybrid mode quality factors and resonance conditions. | Kevin G.Cognee Hugo M.Doeleman Philippe Lalanne A.F.Koenderink | 2019 | Light(Science & Applications)2019，8，1： | 6 |
| 15 | Freeform imaging systems:Fermat's principle unlocks'first time right'design显示文摘For more than 150 years,scientists have advanced aberration theory to describe,analyze and eliminate imperfections that disturb the imaging quality of optical components and systems.Simultaneously,they have developed optical design methods for and manufacturing techniques of imaging systems with ever-increasing complexity and performanee up to the point where they are now including optical elements that are unrestricted in their surface shape.These so-called optical freeform elements offer degrees of freedom that can greatly extend the functionalities and further boost the specifications of state-of-the-art imaging systems.However,the drastically increased number of surface coefficients of these freeform surfaces poses severe challenges for the optical design process,such that the deployme nt of freeform optics remained limited until today.In this paper,we present a deterministic direct optical design method for freeform imaging systems based on differential equations derived from Fermats principle and solved using power series.The method allows calculating the optical surface coefficients that ensure minimal image blurring for each individual order of aberrations.We demonstrate the systematic,deterministic,scalable,and holistic character of our method with catoptric and catadioptric design examples.As such we introduce a disruptive methodology to design optical imaging systems from scratch,we largely reduce the 'trial-and-error',approach in present-day optical design,and we pave the way to a fast-track uptake of freeform elements to create the nextgeneratio n high-end optics.We include a user application that allows users to experience this unique design method hands-on. | Fabian Duerr Hugo Thienpont | 2021 | Light(Science & Applications)2021，10，6： | 5 |
| 16 | Totally intracorporeal robot-assisted urinary diversion for bladder cancer(part 2).Review and detailed characterization of the existing intracorporeal orthotopic ileal neobladder显示文摘Objective:To review the most used intracorporeal orthotopic ileal neobladder(ICONB)after radical cystectomy for bladder cancer and create a unified compendium of the different alternatives,including new consistent images.Methods:We performed a non-systematic review of the literature with the keywords“bladder cancer”,“urinary diversion”,“radical cystectomy”,and“neobladder”.Results:Forty studies were included in the analysis.The most frequent type of ICONB was the modified Studer“U”neobladder(70%)followed by the Hautmann“W”modified neobladder(7.5%),the“Y”neobladder(5%),and the Padua neobladder(5%).The operative time to perform a urinary diversion ranged from 124 to 553 min.The total estimated blood loss ranged from 200 to 900 mL.The rate of positive surgical margins ranged from 0%to 8.1%.Early minor and major complication rates ranged from 0%to 100%and from 0%to 33%,respectively.Late minor and major complication rates ranged from 0%to 70%and from 0%to 25%,respectively.Conclusion:The most frequent types of ICONB are Studer“U”neobladder,Hautmann“W”neobladder,“Y”neobladder,and the Padua neobladder.Randomized studies comparing the performance of the different types of ICONB,the performance in an intra or extracorporeal manner,or the performance of an ICONB versus ICIC are lacking in the literature.To this day,there are not sufficient quality data to determine the supremacy of one technique.This manuscript represents a compendium of the most used ICONB with detailed descriptions of the technical aspects,operative and perioperative outcomes,and new consistent images of each technique. | Hugo Otaola-Arca Kulthe Ramesh Seetharam Bhat Vipul R.Patel Marcio Covas Moschovas Marcelo Orvieto | 2021 | Asian Journal of Urology2021，8，1： | 5 |
| 17 | Incretins and selective renal sodium-glucose co-transporter 2 inhibitors in hypertension and coronary heart disease显示文摘Hyperglycemia is associated with an increased risk of cardiovascular disease,and the consequences ofintensive therapy may depend on the mechanism of the anti-diabetic agent(s)used to achieve a tight control.In animal models,stable analogues of glucagon-like peptide-1(GLP-1)were able to reduce body weight and blood pressure and also had favorable effects on ischemia following coronary reperfusion.In a similar way,dipeptidyl peptidase IV(DPPIV)showed to have favorable effects in animal models of ischemia/reperfusion.This could be due to the fact that DPPIV inhibitors were able to prevent the breakdown of GLP-1 and glucose-dependent insulinotropic polypeptide,but they also decreased the degradation of several vasoactive peptides.Preclinical data for GLP-1,its derivatives and inhibitors of the DPPIV enzyme degradation suggests that these agents may be able to,besides controlling glycaemia,induce cardio-protective and vasodilator effects.Notwithstanding the many favorable cardiovascular effects of GLP-1/incretins reported in different studies,many questions remain unanswered due the limited number of studies in human beings that aim to examine the effects of GLP-1 on cardiovascular endpoints.For this reason,long-term trials searching for positive cardiovascular effects are now in process,such as the CAROLINA and CARMELINA trials,which are supported by small pilot studies performed in humans(and many more animal studies)with incretin-based therapies.On the other hand,selective renal sodium-glucose co-transporter 2 inhibitors were also evaluated in the prevention of cardiovascular outcomes in type 2 diabetes.However,it is quite early to draw conclusions,since data on cardiovascular outcomes and cardiovascular death are limited and long-term studies are still ongoing.In this review,we will analyze the mechanisms underlying the cardiovascular effects of incretins and,at the same time,we will present a critical position about the real value of these compounds in the cardiovascular system and its protection. | Ramiro A Sanchez Hugo Sanabria Cecilia de los Santos Agustin J Ramirez | 2015 | World Journal of Diabetes2015，6，11： | 5 |
| 18 | Smart Grid Cyber Security: An Overview of Threats and Countermeasures显示文摘 | Carlos Lopez Arman Sargolzaei Hugo Santana Carlos Huerta | 2015 | Journal of Energy and Power Engineering2015，9，7： | 5 |
| 19 | Unraveling the Biochemical and Molecular Networks Involved in Maize Cell Habituation to the Cellulose Biosynthesis Inhibitor Dichlobenil显示文摘面对纤维素生合成禁止者 dichlobenil (DCB ) 涉及玉米细胞的使习惯到生长的生物化学、分子的过程被调查。DCB 在活跃、静止的生长阶段两个都影响纤维素的合成并且改变几 CesA 基因的表示。这些, ZmCesA5 和 ZmCesA7 似乎在使熟习起一个主要作用房间到生长面对 DCB。作为在纤维素的减小的后果,涉及 hydroxycinnamates 的合成的几基因的表示被增加,导致有 ferulic 和 p-coumaric 酸的高水平的房间墙。proteomic 分析表明到 DCB 的使习惯在几条新陈代谢的小径被连接到修正。最后,使熟习房间在除去的谷胱甘肽 S-transferase 介绍减小活动和抗氧化剂活动。到纤维素生合成要求的如此的关键进程的骚乱的植物房间改编在几个新陈代谢的网络变化,以便修改房间墙建筑学和新陈代谢,并且面对禁止者幸存。一些这些修正在这份报纸被描述。 | Hugo Melida Antonio Encina Jesus Alvarez Jose Luis Acebes David Caparros-Ruiz | 2010 | Molecular Plant2010，3，5： | 5 |
| 20 | Brazilian biosafety law and the new breeding technologies显示文摘Globally,the area of land cultivated with genetically modified(GM)crops has increased a thousand-fold over the last two decades.Although this technology has become important for food production,the regulatory frameworks that underpin these outcomes are based on a list of requirements for a risk assessment that differ from country to country.In recent years,policymakers have had the opportunity to learn from the controversies over transgenics to create effective regulatory milestones for emerging technologies,allowing them to reach their potential for a more sustainable agriculture,ensuring food security.In Brazil,Law No.11.105 of 24 March 2005 established a framework with four main organizations responsible for risk assessment and management.However,most of new breeding technologies did not exist at that time and were not considered in this law.In2016,Normative Resolution No.16 of the National Biosafety Technical Commission(CTNBio)was established to address this gap based on the evaluation of the products obtained through these techniques(termed Innovative Precision Improvement Techniques in the resolution),in a case-by-case consultation system.Briefly,if the product is designated to be a GM,the developer will have to go through the biosafety requirements and will be approved only after CTNBio risk assessment.If the product is designated not to be GM(for the purposes of the legislation),then it can be registered using the existing procedures.Currently,152 GM products are commercially approved in Brazil.In 2018,CTNBio assessed the first consultation on commercial release of plants generated using the new breeding technologies and has subsequently approved six products.It is expected that many institutions would be able to participate in Brazilian and world markets,developing and introducing new biotechnological solutions and products through a more sustainable approach and without facing public disapproval,a common issue for GM crops. | Alexandre Lima NEPOMUCENO Renata FUGANTI-PAGLIARINI Maria Sueli Soares FELIPE Hugo Bruno Correa MOLINARI Edivaldo Domingues VELINI Eduardo Romano de Campos PINTO Maria Lucia Zaidan DAGLI Galdino ANDRADE FILHO Patricia Machado Bueno FERNANDES | 2020 | Frontiers of Agricultural Science and Engineering2020，7，2： | 5 |
您所在的机构暂未开通此部分的功能，请联系管理员