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| 1 | Elucidation of the ‘Honeycrisp’ pedigree through haplotype analysis with a multi-family integrated SNP linkage map and a large apple (Malus×domestica) pedigree-connected SNP data set显示文摘The apple(Malus×domestica)cultivar Honeycrisp has become important economically and as a breeding parent.An earlier study with SSR markers indicated the original recorded pedigree of‘Honeycrisp’was incorrect and‘Keepsake’was identified as one putative parent,the other being unknown.The objective of this study was to verify‘Keepsake’as a parent and identify and genetically describe the unknown parent and its grandparents.A multi-family based dense and high-quality integrated SNP map was created using the apple 8 K Illumina Infinium SNP array.This map was used alongside a large pedigree-connected data set from the RosBREED project to build extended SNP haplotypes and to identify pedigree relationships.‘Keepsake’was verified as one parent of‘Honeycrisp’and‘Duchess of Oldenburg’and‘Golden Delicious’were identified as grandparents through the unknown parent.Following this finding,siblings of‘Honeycrisp’were identified using the SNP data.Breeding records from several of these siblings suggested that the previously unreported parent is a University of Minnesota selection,MN1627.This selection is no longer available,but now is genetically described through imputed SNP haplotypes.We also present the mosaic grandparental composition of‘Honeycrisp’for each of its 17 chromosome pairs.This new pedigree and genetic information will be useful in future pedigree-based genetic studies to connect‘Honeycrisp’with other cultivars used widely in apple breeding programs.The created SNP linkage map will benefit future research using the data from the Illumina apple 8 and 20 K and Affymetrix 480 K SNP arrays. | Nicholas P Howard Eric van de Weg David S Bedford Cameron P Peace Stijn Vanderzande Matthew D Clark Soon Li Teh Lichun Cai James J Luby | 2017 | Horticulture Research2017，4，1： | 9 |
| 2 | Current and future applications of magnetic resonance imaging and spectroscopy of the brain in hepatic encepha-lopathy显示文摘肝的脑病(他) 普通 neuro 精神病学的畸形,它从肝细胞失败或 portosystemic 与肝疾病和结果复杂化病人的功课正在推延。表明他是广泛地可变的并且从温和无临床症状的骚乱包含一个系列到深昏迷。研究兴趣集中于传播导出勇气的毒素的角色,特别地氨,胀大的大脑的开发和在导致全球 CNS 消沉和混乱功能的服的 neurotransmitter 系统的变化。直到最近,服的功能的直接调查有在人是困难的。然而,当磁性的回声光谱学( 1H 太太)检测的质子在大脑生物化学变化时,新磁性的回声成像( MRI )技术在大脑体积( coregistered MRI )和损害大脑功能( fMRI )提供对变化的评价的一个非侵略的工具,包括服的 osmolytes 的直接测量,例如 myoinositol ,充斥管理对细胞的动态平衡内在的过程的使挫折和夫酸安,包括细胞内部的水的累积。这些细胞内部的 osmolytes 的集中与 hyperammonaemia 改变。有 neuropsychiatric 缺陷并且自从先生系列的严厉的检测太太的代谢物畸形相互关联向正常术后疗法回来,技术可能具有在客观耐心的监视并且在估计各种各样的治疗政体的有效性的使用。 | VP Bob Graver M Alex Dresner Daniel M Forton Serena Counsell David J Larkman Nayna Patel Howard C Thomas Simon D Taylor-Robinson | 2006 | World Journal of Gastroenterology2006，12，19： | 8 |
| 3 | Listeria monocytogenes following orthotopic liver transplantation:Central nervous system involvement and review of the literature显示文摘Listeria monocytogene is a well-recognized cause of bacteremia in immunocompromised individuals,including solid organ transplant recipients,but has been rarely reported following orthotopic liver transplantation. We describe a case of listeria meningitis that occurred within a week after liver transplantation. The patient developed a severe headache that mimicked tacrolimus encephalopathy,and was subsequently diagnosed with listeria meningitis by cerebrospinal fluid culture. The infection was successfully treated with three-week course of intravenous ampicillin. Recurrent hepatitis C followed and was successfully treated with interferon alfa and ribavirin. Fourteen cases of listeriosis after orthotopic liver transplantation have been reported in the English literature. Most reported cases were successfully treated with intravenous ampicillin. There were four cases of listeria meningitis,and the mortality of them was 50%. Early detection and treatment of listeria meningitis are the key to obtaining a better prognosis. | Shugo Mizuno Ivan R Zendejas Alan I Reed Robin D Kim Richard J Howard Alan W Hemming Denise C Schain Consuelo Soldevila-Pico Roberto J Firpi Shiro Fujita | 2007 | World Journal of Gastroenterology2007，13，32： | 2 |
| 4 | Role of microbubble ultrasound contrast agents in the non-invasive assessment of chronic hepatitis C-related liver disease显示文摘长期地感染丙肝病毒的病人经常得长期的肝疾病,对肝损伤的严厉的评价在认为病毒的根除是治疗以前被要求。这篇文章检验从标准答案肝活体检视当前可得到的各种各样的评价方法到血清学的标记和成像。超声是在临床的实践的最广泛地使用的成像形式之一并且已经是为肝疾病的一个首要的诊断工具。Microbubble 超声对比代理人允许更高的分辨率要获得的图象和对要执行的微脉管的变化的功能的评价。在确定的这些代理人的角色肝的损害的状态作为与丙肝在病人决定肝疾病的阶段和等级的一个可行方法被讨论。尽管当前限制了到专家中心,提高对比的超声将不可避免地在临床的背景增加的微水泡的可获得性。 | Scott Grier Adrian KP Lim Nayna Patel Jeremy FL Cobbold Howard C Thomas Isobel J Cox Simon D Taylor-Robinson | 2006 | World Journal of Gastroenterology2006，12，22： | 2 |
| 5 | phenomena of scintillation noise in radar-tracking system显示文摘 | Dunn J H Howard D D king A M | 1959 | Proceedings of IRE1959，47，5： | 1 |
| 6 | Chronic sub-clinical inflammation as part of the insulin resistance syn-drome:the insulin restance atherosclerosis study(IRSA)显示文摘 | Festa A D Agostion R J R Howard G | 2000 | Circulation2000，102，： | 1 |
| 7 | Total knee arthroplasty after high tibial osteotomy:no differences between medial and lateral osteotomy approaches显示文摘 | Preston S Howard J Naudie D | 2014 | Clin Orthop Relat Res2014，472，1： | 1 |
| 8 | Sand transport model of barchan dune equilibrium显示文摘 | Howard A D Morton J B Gad-el-Hak M | 1978 | Sedimentology1978，25，： | 1 |
| 9 | Research strategies for safety evaluation of nanomaterials, Part IV : Risk assessment of nanopartlcles显示文摘 | TSUJI J S MAYNARD A D HOWARD C P | 2006 | Toxicological Sciences2006，89，1： | 1 |
| 10 | Effect of cryoprotective diluent and method of freeze - thawing on survival and acrosomal of ram spermatozoa显示文摘 | Pontbriand D J G Howard M C Schiewe | 1989 | Cryobiology1989，26，： | 1 |
| 11 | Use of organic carbon and loss - on - ignition to estimate soil organic matter in different soil types and horizons显示文摘 | Howard P J A Howard D M | 1990 | Biology and Fertility of soils1990，9，： | 1 |
| 12 | Coal devolatilization and hydrogasification显示文摘 | Anthony D B Howard J B | 1976 | AICHE Journal1976，22，4： | 1 |
| 13 | A functional neuroimaging description of two deep dyslexic patients显示文摘 | Price J Howard D Patterson K | 1998 | Cogn Neurosci1998，10，3： | 1 |
| 14 | A risk-return measure of hedging effectiveness显示文摘 | d' AntonioL J | 1984 | Journal of Financial and Quantitative Analysis1984，，19： | 1 |
| 15 | Health and ecological assessment of polynuclear aromatic hydrocarbons显示文摘 | Santodonato J Howard P Basu D | 1981 | J Environ Patbol Toxicol1981，5，1： | 1 |
| 16 | Influence of bacteria on larval survivaland development in Rhagoletis(Diptera:Tephritidae)显示文摘 | Howard D J Bush G L | 1989 | An-nals of the Entomological Society of America1989，82，： | 1 |
| 17 | Double-blind,randomized,controlled trial of atosiban and rito drine in the treatment of pretterm labor: a multicenter effectiveness and safety study显示文摘 | Moutquin J M herman D S Howard C | | Am J Obstet Gynecol0，182，5： | 1 |
| 18 | The cracking of zinc spangles on hot-dipped galvanized steel显示文摘 | Jaffrey D Brone J D Howard T J | 1980 | Metal Trans B1980，11，12： | 1 |
| 19 | A Risk-return measure of hedging effectiveness显示文摘 | Howard C T Antonio L J D | 1984 | Journal of Financial and Quantitative Analysis1984，19，3： | 1 |
| 20 | Modeling from a seaport level 显示文摘 | HOWARD D L BRAGEN M J | 2004 | Mathematic and Computer Modeling Simulation2004，39，6： | 1 |
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