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2篇 您的检索式：作者名="HOU Hanbin"

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		题名	作者	年代	出处	被引量
	1	Cigarette smoke‑induced malignant transformation via STAT3 signalling in pulmonary epithelial cells in a lung‑on‑a‑chip model显示文摘Background Chronic obstructive pulmonary disease(COPD)is a severe public health problem.Cigarette smoke(CS)is a risk factor for COPD and lung cancer.The underlying molecular mechanisms of CS-induced malignant transformation of bronchial epithelial cells remain unclear.In this study,we describe a lung-on-a-chip to explore the possible mechanistic link between cigarette smoke extract(CSE)-associated COPD and lung cancer.Methods An in vitro lung-on-a-chip model was used to simulate pulmonary epithelial cells and vascular endothelial cells with CSE.The levels of IL-6 and TNF-αwere tested as indicators of inflammation using an enzyme-linked immune sorbent assay.Apical junction complex mRNA expression was detected with qRT-PCR as the index of epithelial-to-mesenchymal transition(EMT).The effects of CSE on the phosphorylation of signal transduction and transcriptional activator 3(STAT3)were detected by Western blotting.Flow cytometry was performed to investigate the effects of this proto-oncogene on cell cycle distribution.Results Inflammation caused by CSE was achieved in a lung-on-a-chip model with a mimetic movement.CSE exposure induced the degradation of intercellular connections and triggered the EMT process.CSE exposure also activated the phosphorylation of proto-oncogene STAT3,while these effects were inhibited with HJC0152.Conclusions CSE exposure in the lung-on-a-chip model caused activation of STAT3 in epithelial cells and endothelial cells.HJC0152,an inhibitor of activated STAT3,could be a potential treatment for CS-associated COPD and lung cancer.	Wei Hou Siyi Hu Ken‑tye Yong Jie Zhang Hanbin Ma	2020	Bio-Design and Manufacturing2020，3，4：	1
	2	ASIAN ARCHITECTURE ARCHIVE CENTER显示文摘Profile:Asian Architectural Archives Center(AAAC)is renovated from an old building of Sipailou Cam-pus of Southeast University in 1930s,which is one of the bungalows nearby the old library.In this project,the main structure is strengthened and repaired,the interior is moderately renovated as well as the performance is improved to adapt to the function replacement of the archive center.	ZHANG Xu SHI Yonggao ZHOU Xiaodi HOU Hanbin CHANG Junfu ZHAO Xiaopeng XUE Liang	2023	Frontiers of Architectural Research2023，12，1：	0

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