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| 1 | Autologous CD34^+ and CD133^+ stem cells transplantation in patients with end stage liver disease显示文摘AIM:To assess the utility of an autologous CD34 + and CD133 + stem cells infusion as a possible therapeutic modality in patients with end-stage liver diseases.METHODS:One hundred and forty patients with endstage liver diseases were randomized into two groups.Group 1,comprising 90 patients,received granulocyte colony stimulating factor for five days followed by autologous CD34 + and CD133 + stem cell infusion in the portal vein.Group 2,comprising 50 patients,received regular liver treatment only and served as a control group.RESULTS:Near normalization of liver enzymes and improvement in synthetic function were observed in 54.5% of the group 1 patients;13.6% of the patients showed stable states in the infused group.None of the patients in the control group showed improvement.No adverse effects were noted.CONCLUSION:Our data showed that a CD34 + and CD133 + stem cells infusion can be used as supportive treatment for end-stage liver disease with satisfactory tolerability. | Hosny Salama Abdel-Rahman N Zekri Abeer A Bahnassy Eman Medhat Hanan A Halim Ola S Ahmed Ghada Mohamed Sheren A Al Alim Ghada M Sherif | 2010 | World Journal of Gastroenterology2010，16，42： | 16 |
| 2 | Role of relevant immune-modulators and cytokines in hepatocellular carcinoma and premalignant hepatic lesions显示文摘AIM To assess the levels of different immune modulators in patients with hepatocellular carcinoma(HCC),in relation to other hepatic diseases.METHODS Eighty-eight patients were included in the current study and represented patients with HCC(20),liver cirrhosis(28) and chronic hepatitis(CH;25),and normal controls(NC;15).Peripheral blood was isolated for immunophenotyping of active myeloid dendritic cells(m DCs;CD1 c and CD40),mature inactive myeloid cells(CD1 c and HLA),active plasmacytoid cells(p DCs;CD303 and CD40),mature inactive p DCs(CD30 and HLA),active natural killer(NK) cells(CD56 and CD161),active NK cells(CD56 and CD314) and inactive NK cells(CD56 and CD158) was done by flow cytometry.Serum levels of interleukin(IL)-2,IL-10,IL-12,IL-1β,interferon(IFN)-α,IFN-γ and tumor necrosis factor(TNF)-αR2 were assessed by ELISA.RESULTS Active m DCs(CD1 C+/CD40+) and inactive m DCs(CD1 c+/HLA+) were significantly decreased in HCC patients in relation to NC(P < 0.001).CD40+ expression on active p DCs was decreased in HCC patients(P < 0.001),and its level was not significantly changed among other groups.Inactive p DCs(CD303+/HLA+),inactive NKs(CD56+/CD158+) and active NKs(CD56+/CD161+) were not statistically changed among the four groups studied;however,the latter was increased in CH(P < 0.05).NKG2 D was statistically decreased in HCC,CH and cirrhosis(P < 0.001),and it was not expressed in 63%(12/20) of HCC patients.There was significant decrease of IL-2,IFN-α and IFN-γ(P < 0.001),and a significant increase in IL-10,IL-1β,and TNF-αR2(P <0.01,P < 0.001 and P < 0.001;respectively) in HCC patients.There was inverted correlation between IL-12 and IL-1β in HCC(r =-0.565,P < 0.01),with a strong correlation between p DCs(CD303+/CD40+) and NKs(CD56+/CD161+;r = 0.512,P < 0.05) as well as inactive m DCs(CD1 c+/HLA+) and inactive NK cells(CD56+/CD158+;r = 0.945,P < 0.001).CONCLUSION NKG2 D,CD40,IL-2 and IL-10 are important modulators in the development and progression of HCC. | Abdel-Rahman N Zekri Somaya El Deeb Abeer A Bahnassy Abeer M Badr Mona S Abdellateif Gamal Esmat Hosny Salama Marwa Mohanad Ahmed Esam El-dien Shimaa Rabah Assmaa Abd Elkader | 2018 | World Journal of Gastroenterology2018，24，11： | 6 |
| 3 | A study on the corrosion behavior of aluminum alloys in seawater显示文摘 | Hosni Ezuber E1-Houd A E1-Shawesh F | 2008 | Materials and Design2008，29，： | 1 |
| 4 | A new type of synthesis oil, 2,3-thiadiazole and 1,2,3-diazaphosphole derivatives via Hurd-Mori cyclization 显示文摘 | Hosny M A El-sayed T H El-sawi E A | 2012 | E-Journal of Chemistry2012，9，3： | 1 |
| 5 | Quality Control Inspection Knowledge-Based Qua lity Control System显示文摘 | Y A Hosni A K Elshennawy | 1988 | Computers and Industry Engineering1988，15，14： | 1 |
| 6 | A dynamic model for a gas-liquid corona discharge using neural networks显示文摘 | HOSNY A A HOPKINS D C GAY Z B | 2009 | IEEE Transactions on Power Delivery2009，24，3： | 1 |
| 7 | Reverse engineering and relevance to industrial engineering: A critical review 显示文摘 | Bapaya Bidanda Yasser A Hosni | 1994 | Computer ind Engng1994，26，2： | 1 |
| 8 | Six cases of fibromatosis of the head and neck in children显示文摘 | TOSTEVIN P M WYATT M HOSNI A | 2000 | Int J Pediatr Otorhinolaryngol2000，53，： | 1 |
| 9 | Assessment of lung cancer risk dueto exposure to radon from coastal sediments显示文摘 | El - Gamal A Hosny G | 2008 | East Medi-terr Health J2008，14，6： | 1 |
| 10 | Measurenaent of chlorine dioxide penetration in dairy process pipe biofilms during disinfection显示文摘 | Jang A Szaho J Hosni A A | 2006 | Applied microbiology and biotechnology2006，72，2： | 1 |
| 11 | Novel bis(1 acyl 2- pyrazolines) of potential anti inflammatory and molluscicidal properties显示文摘 | Barsoum F F Hosni H M Girgis A S | 2006 | Bioorganic & Medicinal Chemistry2006，14，11： | 1 |
| 12 | Effect of coating of aluminum carboxymethyl -cellulose beads on the release and bioavailability of diclofenac sodium显示文摘 | Hosny E A A1-Helw A A | 1998 | Pharm Acta Helve1998，72，： | 1 |
| 13 | Hypoglycemic effect of oral insulin in diabetic rabbits using pH-dependent coated capsules containing sodium salicylate without and with sodium cholate 显示文摘 | HOSNY E A GHILZAI N M ALONAJAR T A | 1998 | Drug Dev Ind Pharm1998，24，3： | 1 |
| 14 | Oral delivery of insulin from enteric-coated capsules containing sodium salicylate: effect on rela- tive hypoglycemia of diabetic beagle dog 显示文摘 | Hosny E A AL2Shora H I Elmazar M A | 2002 | Int J Pharm2002，237，12： | 1 |
| 15 | Effective intestinal absorption of insulin in diabetic rats using enteric coated capsules containing sodium salicylate 显示文摘 | Hosny E A Ghilzai N M K Al-Dhawalie A H | 1995 | Drug Dev Ind Pharm1995，21，： | 1 |
| 16 | Assessment of lung cancer risk due to exposure to radon from coastal sediments 显示文摘 | El-Gamal A Hosny G | 2008 | East Mediterr Health J2008，14，： | 1 |
| 17 | Metal chelates with some cellulose derivatives (Ⅲ): Synthesis and structural chemistry of nickel (Ⅱ) and copper (Ⅱ) complexes with carboxymethyl cellulose 显示文摘 | Hosny W M Abdel Hadi A K EI-Saied H Basta A H | 1995 | Polymer International1995，37，： | 1 |
| 18 | Combination of vitamin E and clomiphene citrate in treating patients with idiopathic oligoastheno- zoospermia:aprospective,randomized trial 显示文摘 | EISheikh MG Hosny MB Elshenoufy A | 2015 | Andrology2015，3，5： | 1 |
| 19 | Reliability analysis of structures using neural network method显示文摘 | A HOSNI ELHEWY E MESBAHI Y PU | 2006 | Probabilistic Engineering Mechanics2006，21，1： | 1 |
| 20 | Metal chelates with some cellulose derivative(Part Ⅲ):synthesis and structural chelating of nickel (Ⅱ) and copper (Ⅱ) complexes with carboxymehtyl cellulose显示文摘 | Hosny W M Abdel-Hadi A K | 1995 | Polymer International1995，37，2： | 1 |
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