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| 1 | 亚洲地区肺炎支原体和肺炎衣原体在成人社区获得性肺炎中的流行病学研究显示文摘目的由Malaya大学医学中心牵头进行的非典型病原在亚洲社区获得性肺炎(CAP)患者中的流行病学研究。结果显示,肺炎支原体和肺炎衣原体分别占成人病原的11.4%和5.8%。本研究将对这2种病原所致感染的临床和实验室资料进一步总结分析。方法亚洲7个国家12个研究中心采用统一的检测方法(DNA检测及血清学方法)和判断标准,对16岁以上的CAP患者进行肺炎支原体和肺炎衣原体的检测。结果在急性肺部感染者中,肺炎支原体和肺炎衣原体肺炎的临床表现与其他病原所致者非常相似,并无特征性。肺炎支原体和肺炎衣原体在男性和女性中检出率相仿,但肺炎支原体感染在16至44岁患者中更为多见(22.2%),而肺炎衣原体感染者重症患者相对较多。88例在病程中血清抗体显著增高的肺炎支原体感染者中,48例(54.5%)患者急性期抗体阴性,如果未检测恢复期血清抗体,上述患者则会漏诊;51例肺炎衣原体感染者中急性期血清抗体阴性则较为少见(21.6%)。肺炎支原体和肺炎衣原体既往感染和(或)病原携带率分别为5.7%和7.9%。结论肺炎支原体肺炎和肺炎衣原体肺炎发病率高,诊断困难,因此在亚洲成人CAP抗感染经验治疗时宜选用对这2种病原亦有效的药物。 | 黄海辉 张婴元 汪复 Mediadora SANIEL Marissa ALEJANDRIA Seung-Chul PARK 刘又宁 Po-Ren HSUEH Ahmad M. AZIAH Wing-Hong SETO Cecilia C. L. NGAN Mangunnegoro HADIARTO Subharee SUWANJUTHA Yun-Fong NGEOW Alsagaff HOOD | 2008 | 中国感染与化疗杂志2008，8，2： | 67 |
| 2 | Human Gut Microbiota and Gastrointestinal Cancer显示文摘Human gut microbiota play an essential role in both healthy and diseased states of humans.In the past decade,the interactions between microorganisms and tumors have attracted much attention in the efforts to understand various features of the complex microbial communities,as well as the possible mechanisms through which the microbiota are involved in cancer prevention,carcinogenesis,and anti-cancer therapy.A large number of studies have indicated that microbial dysbiosis contributes to cancer susceptibility via multiple pathways.Further studies have suggested that the microbiota and their associated metabolites are not only closely related to carcinogenesis by inducing in?ammation and immune dysregulation,which lead to genetic instability,but also interfere with the pharmacodynamics of anticancer agents.In this article,we mainly reviewed the in?uence of gut microbiota on cancers in the gastrointestinal(GI)tract(including esophageal,gastric,colorectal,liver,and pancreatic cancers)and the regulation of microbiota by diet,prebiotics,probiotics,synbiotics,antibiotics,or the Traditional Chinese Medicine.We also proposed some new strategies in the prevention and treatment of GI cancers that could be explored in the future.We hope that this review could provide a comprehensive overview of the studies on the interactions between the gut microbiota and GI cancers,which are likely to yield translational opportunities to reduce cancer morbidity and mortality by improving prevention,diagnosis,and treatment. | Changting Meng Chunmei Bai Thomas D. Brown Leroy E. Hood Qiang Tian | 2018 | Genomics, Proteomics & Bioinformatics2018，16，1： | 43 |
| 3 | 截断式脉冲射流流场结构模拟与冲蚀硬岩能力分析显示文摘孔盘截断式脉冲射流能够充分利用水锤压力、高速侧向流、循环载荷等效应,破岩效率高,在硬岩破碎中具有较高的开发潜力。基于VOF模型和动网格技术,建立与截断式脉冲射流生成装置几何及运动过程一致的两相流瞬态计算模型,结合高速摄像技术,研究了截断式脉冲水射流的流体结构的动态演变动力特征,测试了截断式脉冲水射流的破岩能力,并分别从流畅结构和破岩能力上与常规圆柱水射流进行了对比分析。研究结果表明:截断式脉冲射流有助于在射流末端形成偏转的瓦状尖体结构,可有效减弱或避免激波阻力的影响;截断式脉冲水射流在破岩过程中,岩石靶物冲蚀孔口呈现非轴对称形态,与常规圆柱射流相比,截断式脉冲射流能够大幅度提升破岩速度,增大破岩体积。 | 陆朝晖 卢义玉 Michael Hood 潘林华 贺培 | 2017 | 振动与冲击2017，36，19： | 9 |
| 4 | Endoscopic papillary large balloon dilatation with sphincterotomy is safe and effective for biliary stone removal independent of timing and size of sphincterotomy显示文摘AIM To describe the efficacy and safety of endoscopic papillary large balloon dilatation(EPLBD) in the management of bile duct stones in a Western population. METHODS Data was collected from the endoscopic retrograde cholangiopancreatography(ERCP) and Radiology electronic database along with a review of case notes over a period of six years from 1 st August 2009 to 31 st July 2015 and incorporated into Microsoft excel. Statistical analyses were performed using Med Calc for Windows,version 12.5(Med Calc Software,Ostend,Belgium). Simple statistical applications were applied in order to determine whether significant differences exist in comparison groups. We initially used simple proportions to describe the study populations. Furthermore,we used chi-square test to compare proportions and categorical variables. Non-parametric Mann-Whitney U-test was applied in order to compare continuous variables. All comparisons were deemed to be statistically significant if P values were less than 0.05.RESULTS EPLBD was performed in 229 patients(46 females) with mean age of 68 ± 14.3 years. 115/229(50%) patients had failed duct clearance at previous ERCP referred from elsewhere with standard techniques. Duct clearance at the Index* ERCP(1 st ERCP at our centre) was 72.5%. Final duct clearance rate was 98%. EPLBD after fresh sphincterotomy was performed in 81(35.4%). Median balloon size was 13.5 mm(10-18). In addition to EPLBD,per-oral cholangioscopy(POC) and electrohydraulic lithotripsy(EHL) was performed in 35(15%) patients at index* ERCP. 63(27.5%) required repeat ERCP for stone clearance. 28(44.5%) required POC and EHL and 11(17.4%) had repeat EPLBD for complete duct clearance. Larger stone size(12.4 mm vs 17.4 mm,P < 0.000001),multiple stones(2,range(1-13) vs 3,range(1-12),P < 0.006) and dilated common bile duct(CBD)(12.4 mm vs 18.3 mm,P < 0.001) were significant predictors of failed duct clearance at index ERCP. 47 patients(20%) had ampullary or peri-ampullary diverticula. Procedure related adverse events included 2 cases of bleeding and pancreatitis(0.87%) each.CONCLUSION EPLBD is a safe and effective technique for CBDS removal. There is no difference in outcomes whether it is performed at the time of sphincterotomy or at a later procedure or whether there is a full or limited sphincterotomy. | Usman Iqbal Aujla Nimzing Ladep Laura Dwyer Stephen Hood Nicholas Stern Richard Sturgess | 2017 | World Journal of Gastroenterology2017，23，48： | 8 |
| 5 | Systems Approaches to Biology and Disease Enable Translational Systems Medicine显示文摘The development and application of systems strategies to biology and disease are transforming medical research and clinical practice in an unprecedented rate.In the foreseeable future,clinicians,medical researchers,and ultimately the consumers and patients will be increasingly equipped with a deluge of personal health information,e.g.,whole genome sequences,molecular profiling of diseased tissues,and periodic multi-analyte blood testing of biomarker panels for disease and wellness.The convergence of these practices will enable accurate prediction of disease susceptibility and early diagnosis for actionable preventive schema and personalized treatment regimes tailored to each individual.It will also entail proactive participation from all major stakeholders in the health care system.We are at the dawn of predictive,preventive,personalized,and participatory(P4) medicine,the fully implementation of which requires marrying basic and clinical researches through advanced systems thinking and the employment of high-throughput technologies in genomics,proteomics,nanofluidics,single-cell analysis,and computation strategies in a highly-orchestrated discipline we termed translational systems medicine. | Leroy Hood Qiang Tian | 2012 | Genomics, Proteomics & Bioinformatics2012，10，4： | 8 |
| 6 | Demotivation: Affective states and learning outcomes显示文摘 | Joseph Falout James Elwood Michael Hood | 2009 | System2009，，3： | 5 |
| 7 | Symptoms of irritable bowel syndrome in patients with inflammatory bowel disease: examining the role of sub‐clinical inflammation and the impact on clinical assessment of disease activity显示文摘 | J. W. Berrill J. T. Green K. Hood A. K. Campbell | 2013 | Aliment Pharmacol Ther2013，，1： | 4 |
| 8 | From Phage lambda to human cancer: endogenous molecular-cellular network hypothesis显示文摘 | Gaowei Wang Xiaomei Zhu Leroy Hood Ping Ao | 2013 | Frontiers of Electrical and Electronic Engineering in China2013，8，1： | 4 |
| 9 | WONCA研究论文摘要汇编——提高基层医疗中尿路感染幼儿的诊断和治疗:来自DUTY前瞻性诊断队列研究结果显示文摘目的基层医疗中有多达50%的尿路感染(UTIs)患儿被忽视。尿液培养是诊断的关键,但收集尿液通常很难。本文旨在通过以下方式对两步骤的临床规则进行内部验证:(1)按症状和体征来选择儿童进行尿液收集;(2)进行症状、体征和试纸测试以指导抗生素治疗。方法从英格兰和威尔士的基层医疗机构中选取5岁以下急性发病儿童233例。指数测试包括父母反映的症状、临床医生报告的体征、尿试纸结果以及关于尿路感染可能性的临床医生选择。以清洁尿样中的微生物培养结果作为确认尿路感染的参考标准。计算灵敏度、特异度、和基于系数(分级严重性)和分数(二分)的症状/体征的Logistic回归模型的受试者工作特征曲线下面积(AUROC),然后采用引导指令内部验证AUROC。结果 3 036例儿童提供了尿样,获得2 740份(90%)培养结果,其中60份(2.2%)呈阳性。临床诊断灵敏度为46.6%,AUROC为0.77。基于系数和分数的经验证模型的AUROC分别为0.87和0.86,在加入亚硝酸盐试纸、白细胞和血液后其分别增加至0.90和0.90。结论根据症状和体征的临床规则优于临床诊断,在识别儿童进行无创尿液取样方面表现良好。试纸结果为经验性抗生素治疗提供了进一步的诊断价值。 | HAY A D STERNE J A HOOD K 本刊编辑部 | 2016 | 中国全科医学2016，19，28： | 3 |
| 10 | Lessons Learned as President of the Institute for Systems Biology(2000–2018)显示文摘I stepped down as president of the Institute for Systems Biology(ISB)on Jan 1,2018.As I think about my 17-year term as President,I am astounded at how much I have learned,not only about science but also about,among other things,what it takes to build a unique world-class institution.The beginningsI came to the non-pro?t,independent ISB from 30 years in academia.For 22 years,I was a faculty member of Division of Biology at the California Institute of Technology(Caltech), | Leroy E. Hood | 2018 | Genomics, Proteomics & Bioinformatics2018，16，1： | 3 |
| 11 | Synthesis of RE(OH)_2Cl and REOCl (RE=Eu, Tb) nanostructures显示文摘Anisotropic structures, nanoneedles, and nanospindles of rare earth hydroxychloride (RE(OH)2Cl) and oxychloride (REOCl) (rare earth=Eu and Tb) were synthesized. The rare earth hydroxychloride nanostructures were formed via a thermally assisted hydrolysis of the rare-earth sesquioxide nanocrystals. The morphological evolution of the nanostructures was studied using high-resolution transmission elec- tron microscopy and scanning electron microscopy, while the structural evolution was investigated using X-ray diffraction techniques. The thermal stability of the rare earth hydroxychlorides was investigated using thermogravimetric analysis. The rare earth oxychloride nanospin- dles were synthesized via a simple heat-treatment of rare earth hydroxychloride nanospindles. | S. V. Mahajan J. Hart J. Hood A. Everheart M. L. Redigolo D. S. Koktysh E. A. Payzant J. H. Dickerson | 2008 | Journal of Rare Earths2008，26，2： | 2 |
| 12 | Characterizing Thermal Augmentation of Convection-Enhanced Drug Delivery with the Fiberoptic Microneedle Device显示文摘Convection-enhanced delivery(CED) is a promis ing technique leveraging pressure-driven flow to increase penetration of infused drugs into interstitial spaces. We have developed a fiberoptic microneedle device for inducing local sub-lethal hyperthermia to further improve CED drug distribution volumes, and this study seeks to quantitatively characterize this approach in agarose tissue phantoms. Infusions of dye were conducted in 0.6%(w/w) agarose tissue phantoms with isothermal conditions at 15 °C, 20 °C, 25 °C, and 30 °C. Infusion metrics were quantifled using a custom shadowgraphy setup and imageprocessing algorithm. These data were used to build an empirical predictive temporal model of distribution volume as a function of phantom temperature. A second set of proof of-concept experiments was conducted to evaluate a novel fiberoptic device capable of generating local photothermal heating during fluid infusion. The isothermal infusions showed a positive correlation between temperature and distribution volume, with the volume at 30 °C showing a 7-fold increase at 100 min over the 15 °C isothermal case. Infusions during photothermal heating(1064 nm at 500 mW) showed a similar eff ect with a 3.5-fold increase at 4 h over the control(0 mW). These results and analyses serve to provide insight into and characterization of heat-mediated enhancement of volumetric dispersal. | R.Lyle Hood Rudy T.Andriani Tobias E.Ecker John L.Robertson Christopher G.Rylander | 2015 | Engineering2015，1，3： | 2 |
| 13 | Extracellular microRNA: A new source of biomarkers显示文摘 | Alton Etheridge Inyoul Lee Leroy Hood David Galas Kai Wang | 2011 | Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis2011，，1： | 2 |
| 14 | Multifocal VEP and ganglion cell damage:applications and limitations for the study of glaucoma显示文摘 | HOOD D C GREENSTEIN V C | 2003 | Prog Retin Eye Res2003，22，2： | 1 |
| 15 | Determining abnormal interocular latencies of multifocal visual evoked potentials显示文摘 | Hood DC Zhang X Rodarte C | 2004 | Doc Ophthalmol2004，109，2： | 1 |
| 16 | Predicting and preventing water condensation in sampled vehicle exhaust for optimal CVS dilution 显示文摘 | Hood JF Silvis WM | 1998 | SAE Transactions1998，17，4： | 1 |
| 17 | Putting e-Jidence into practiceevidence- based interventions for fatigue during and following cancer and its treatment显示文摘 | MitcheU SA Beck SL Hood LE | 2007 | Clin J Oncol Nurs2007，，1： | 1 |
| 18 | Use of chlirine dioxide to disinfect dental unit waterlines显示文摘 | Smith A J Bagge J Hood J | 2001 | Journal of Hospital Infection2001，49，4： | 1 |
| 19 | ARI-1: b-lactamase-mediated imipenem resistance in Acinetobacter baumannii显示文摘 | Paton R Miles R S Hood J | 1993 | Int J Antimicrob Agents1993，2，： | 1 |
| 20 | α-Zr self-diffusion anisotropy 显示文摘 | Hood G M Zou H Gupta D | 1995 | Journal of Nuclear Materials1995，223，2： | 1 |
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