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2篇 您的检索式：作者名="Christopher G.Rylander"

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		题名	作者	年代	出处	被引量
	1	Characterizing Thermal Augmentation of Convection-Enhanced Drug Delivery with the Fiberoptic Microneedle Device显示文摘Convection-enhanced delivery(CED) is a promis ing technique leveraging pressure-driven flow to increase penetration of infused drugs into interstitial spaces. We have developed a fiberoptic microneedle device for inducing local sub-lethal hyperthermia to further improve CED drug distribution volumes, and this study seeks to quantitatively characterize this approach in agarose tissue phantoms. Infusions of dye were conducted in 0.6%(w/w) agarose tissue phantoms with isothermal conditions at 15 °C, 20 °C, 25 °C, and 30 °C. Infusion metrics were quantifled using a custom shadowgraphy setup and imageprocessing algorithm. These data were used to build an empirical predictive temporal model of distribution volume as a function of phantom temperature. A second set of proof of-concept experiments was conducted to evaluate a novel fiberoptic device capable of generating local photothermal heating during fluid infusion. The isothermal infusions showed a positive correlation between temperature and distribution volume, with the volume at 30 °C showing a 7-fold increase at 100 min over the 15 °C isothermal case. Infusions during photothermal heating(1064 nm at 500 mW) showed a similar eff ect with a 3.5-fold increase at 4 h over the control(0 mW). These results and analyses serve to provide insight into and characterization of heat-mediated enhancement of volumetric dispersal.	R.Lyle Hood Rudy T.Andriani Tobias E.Ecker John L.Robertson Christopher G.Rylander	2015	Engineering2015，1，3：	2
	2	PARAMETRIC STUDY OF TISSUE OPTICAL CLEARING BY LOCALIZED MECHANICAL COMPRESSION USING COMBINED FINITE ELEMENT AND MONTE CARLO SIMULATION显示文摘Tissue Optical Clearing Devices(TOCDs)have been shown to increase light transmission through mechanically compressed regions of naturally turbid biological tissues.We hypothesize that zones of high compressive strain induced by TOCD pins produce localized water displacement and reversible changes in tissue optical properties.In this paper,we demonstrate a novel combined mechanical finite element model and optical Monte Carlo model which simulates TOCD pin compression of an ex vivo porcine skin sample and modified spatial photon fluence distributions within the tissue.Results of this simulation qualitatively suggest that light transmission through the skin can be significantly affected by changes in compressed tissue geometry as well as concurrent changes in tissue optical properties.The development of a comprehensive multi-domain model of TOCD application to tissues such as skin could ultimately be used as a framework for optimizing future design of TOCDs.	WILLIAM C.VOGT HAIOU SHEN GE WANG CHRISTOPHER G.RYLANDER	2010	Journal of Innovative Optical Health Sciences2010，3，3：	0

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