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| 1 | Monomethyl fumarate augments NK cell lysis of tumor cells through degranulation and the upregulation of NKp46 and CDIO7a显示文摘Dimethyl fumarate (DMF ) 是使用到对待的新药多重硬化(MS ) 病人。这里,我们在生来的杀手(NK ) 的各种各样的活动检验了 DMF 和 DMF 代谢物 monomethyl fumarate (MMF ) 的效果房间。我们证明 MMF 扩充 K562 和 RAJI 肿瘤房间的主要 CD56 +, 然而并非 CD56 −, NK 房间细胞溶解。MMF 为 24 h 在孵化以后在 CD56 +, 然而并非 CD56 −, NK 房间的表面上导致了 NKp46 表示。这效果密切通过这代谢物从这些房间在 CD56 + NK 房间和 Granzyme B 版本的正式就职的表面上与 CD107a 表示的 upregulation 被相关。anti-NKp46 抗体通过 CD56 + NK 房间禁止了 CD107a 的导致 MMF 的 upregulation 和肿瘤房间的细胞溶解。因此,这些结果是第一证明 MMF 扩充肿瘤目标房间的 CD56 + NK 房间细胞溶解,效果通过 NKp46 调停了。这新奇效果在癌症为治疗学或预防的协议建议 MMF 的使用。 | Heidi Vego Kristin L Sand Rune A Hoglund Lars-Egil Fallang Glenn Gundersen Trygve Holmoy Azzam A Maghazachi | 2016 | Cellular & Molecular Immunology2016，13，1： | 2 |
| 2 | Evaluation of individually ventilated cage systems for laboratory rodents: occupational health aspects 显示文摘 | Renstrom A Bjoring G Hoglund AU | 2001 | Laboratory Animal2001，35，1： | 1 |
| 3 | DICTRA,a tool for simulation of diffusion transformations in alloys显示文摘 | Borgenstam A Engstrom A Hoglund L | 2000 | Journal of Phase Equilibria2000，21，3： | 1 |
| 4 | Antisense oligodeoxynucleotide inhibition as a potent strategy in plant biology :identification of SUSIBA2 as a transcriptional activator in plant sugar signaling显示文摘 | SUN C X HOGLUND A S OLSSON H | 2005 | Plant J2005，44，1： | 1 |
| 5 | MultiLoe: prediction of protein subeellular localization using N-terminal targeting sequences, sequence motifs and amino acid composition 显示文摘 | Hoglund A Donnes P Blum T | 2006 | Bioinformaties2006，22，10： | 1 |
| 6 | Different myrosinase and idioblast distribution in Arabidopsis and Brassica napus显示文摘 | ANDREASSON E BOLT JORGENSEN L HOGLUND A S | 2001 | Plant Physiol2001，127，4： | 1 |
| 7 | MultiLoc: prediction of protein subcellular localization using N- terminal targeting sequences, sequence motifs, and amino acid composition 显示文摘 | Hoglund A Donnes P Blum T | 2006 | Bioinformatics2006，22，10： | 1 |
| 8 | A tool for simulation of diffusional transformations in alloys 显示文摘 | Borgenstam A Engstron A Hoglund L | 2000 | Phase Equilib2000，21，： | 1 |
| 9 | Evaluation of individually ventilated cage systems for laboratory rodents:cage environment and animal health aspects显示文摘 | Hoglund A U Renstrom A | 2001 | Laboratory Animal2001，35，1： | 1 |
| 10 | Seed-specific overexpression of an endogenous arabidopsis phytoene synthase gene results in delayed germination and increased levels of carotenoids, chlorophyll, and abscisic Acid 显示文摘 | Lindgren L O Stalberg K G Hoglund A S | 2003 | Plant Physiol2003，132，： | 1 |
| 11 | Safflower microsomes catalyse oil accumulation in vit ro:a model system 显示文摘 | STOBART A K STYMNE S HOGLUND S | 1986 | Planta1986，169，1： | 1 |
| 12 | Microsatellite markers reveal the potential for kin selection on black grouse leks显示文摘 | Hoglund J Alatalo RV Lundberg A | 1999 | Proceedings of the Royal Society Biological Sciences Series B1999，266，1421： | 1 |
| 13 | Distribution of myrosinase in rapeseed tussues显示文摘 | HOGLUND A S LENMAN M FALK A | 1991 | Plant Physiol1991，95，： | 1 |
| 14 | Biological half-lives of polybrominated diphenyl ethers and tetrabromobisphenol in exposed workers显示文摘 | Hagmar L Sjodin A Hoglund P | 2000 | Organohalog Compd2000，47，： | 1 |
| 15 | Myrosinase is localized to the interior of myrosin grains and is not associated to the surrounding tonoplast membrane显示文摘 | HOGLUND A S LENMAN M RASK L | 1992 | Plant Science1992，85，： | 1 |
| 16 | Myrosinase is localized to the interior of myrosin grains and is not associated to the surrounding tonoplast membrane显示文摘 | HOGLUND A S LENMAN M RASK L | 1992 | Plant Science1992，85，： | 1 |
| 17 | Distribution of myrosinase in rapeseed tissues显示文摘 | HOGLUND A S LENMAN M FALK A | 1991 | Plant Physiol1991，95，： | 1 |
| 18 | Developmental regulation of VEIDase caspase-like proteolytic activity in barley caryopsis显示文摘 | BOREN M HOGLUND A S BOZHKOV P | 2006 | Journal of Experimental Botany2006，57，14： | 1 |
| 19 | ^18F-ML-10, a PET tracer for apoptosis: first human study显示文摘 | Hoglund J Shirvan A Antoni G | 2011 | J Nucl Med2011，52，： | 1 |
| 20 | ATP gamma S disrupts human immunodeficiency virus typeⅠvirion core integrity显示文摘 | Hoglund A Hoglund S | 2005 | J Virol2005，79，9： | 1 |
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