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| 1 | Monomethyl fumarate augments NK cell lysis of tumor cells through degranulation and the upregulation of NKp46 and CDIO7a显示文摘Dimethyl fumarate (DMF ) 是使用到对待的新药多重硬化(MS ) 病人。这里,我们在生来的杀手(NK ) 的各种各样的活动检验了 DMF 和 DMF 代谢物 monomethyl fumarate (MMF ) 的效果房间。我们证明 MMF 扩充 K562 和 RAJI 肿瘤房间的主要 CD56 +, 然而并非 CD56 −, NK 房间细胞溶解。MMF 为 24 h 在孵化以后在 CD56 +, 然而并非 CD56 −, NK 房间的表面上导致了 NKp46 表示。这效果密切通过这代谢物从这些房间在 CD56 + NK 房间和 Granzyme B 版本的正式就职的表面上与 CD107a 表示的 upregulation 被相关。anti-NKp46 抗体通过 CD56 + NK 房间禁止了 CD107a 的导致 MMF 的 upregulation 和肿瘤房间的细胞溶解。因此,这些结果是第一证明 MMF 扩充肿瘤目标房间的 CD56 + NK 房间细胞溶解,效果通过 NKp46 调停了。这新奇效果在癌症为治疗学或预防的协议建议 MMF 的使用。 | Heidi Vego Kristin L Sand Rune A Hoglund Lars-Egil Fallang Glenn Gundersen Trygve Holmoy Azzam A Maghazachi | 2016 | Cellular & Molecular Immunology2016，13，1： | 2 |
| 2 | : Identification of cytogenetic subgroups and karyotypic pathways of clonal evolution in follicular lymphomas 显示文摘 | Hoglund M Sehn L Connors JM | 2004 | Genes Chromosomes Cancer2004，39，： | 1 |
| 3 | Approximate geodesic distances reveal biologically relevant structures in microarray data 显示文摘 | Nilsson J Fioretos T Hoglund M | 2004 | Bioinformaties2004，20，6： | 1 |
| 4 | Iscom, a novel structure for antigenic presentation of membrane proteins from enveloped viruses显示文摘 | Sundquist B Hoglund S | 1984 | Nature (London)1984，308，： | 1 |
| 5 | Evaluation of individually ventilated cage systems for laboratory rodents: occupational health aspects 显示文摘 | Renstrom A Bjoring G Hoglund AU | 2001 | Laboratory Animal2001，35，1： | 1 |
| 6 | Identification of cytogenetic subgroups and karyotypic pathways in tran- sitional cell carcinoma显示文摘 | Hoglund M Sail T Heim S | 2001 | Cancer Res2001，61，： | 1 |
| 7 | DICTRA,a tool for simulation of diffusion transformations in alloys显示文摘 | Borgenstam A Engstrom A Hoglund L | 2000 | Journal of Phase Equilibria2000，21，3： | 1 |
| 8 | Antisense oligodeoxynucleotide inhibition as a potent strategy in plant biology :identification of SUSIBA2 as a transcriptional activator in plant sugar signaling显示文摘 | SUN C X HOGLUND A S OLSSON H | 2005 | Plant J2005，44，1： | 1 |
| 9 | Pharmacoki- netics of thalidomide in patients with impaired renal function and while on and off dialysis 显示文摘 | Eriksson T Hoglund P Turesson I | 2003 | J Pharm Pharmacol2003，55，： | 1 |
| 10 | Iscoms and immunostimulation with viral antigens显示文摘 | Dalagard K | 1989 | Subcellular Biochem1989，15，： | 1 |
| 11 | Atrioventricular plane displacement in severe congestive ssessment of rheart failure following dilated cardiomyopathy or myocardial infarction显示文摘 | Alam M Hoglund C Thorstrand C | 1990 | J Intern Med1990，228，6： | 1 |
| 12 | Nerve growth factor levels and localisation in human asthmatic bronchi 显示文摘 | Olgart Hoglund C de Blay F Oster JP | 2002 | Eur Respir J2002，20，5： | 1 |
| 13 | Influence of Luhrieant Properties on Elasto- hydrodynamic, Lubrieation 显示文摘 | Hoglund E | 1999 | Wear1999，232，： | 1 |
| 14 | Thermo-Calc and DICTRA,computational tools for materials science显示文摘 | Andersson J O Helander T Hoglund L | 2002 | CALPHAD2002，26，2： | 1 |
| 15 | Elimination of S100( and renal function after cardiac surgery显示文摘 | Jonsson H Johnsson P Hoglund P | 2000 | J Cardiothorac Vasc Anesth2000，14，6： | 1 |
| 16 | Current perspectives of natural killer cell education by MHC class I molecules显示文摘 | Hoglund P Brodin P | 2010 | Nature RevImmunol2010，10，10： | 1 |
| 17 | Pharmacokinetics of Thalidomide in Patients with Impaired Renal Function and While on and off Dialysis显示文摘 | Eriksson T Hoglund P Turesson I | 2003 | Journal of Pharmacy and Pharmacology2003，55，： | 1 |
| 18 | Assessment by echocardiogram of left ven- tricular diastolic function in healthy subjects using the arrio- venticular plane displacement 显示文摘 | Alam M Hoglund C | 1992 | Am J Cardiol1992，65，4： | 1 |
| 19 | Gender aspects of survival after surgical treatment for rectal cancer显示文摘 | Lydrup ML Hoglund P | 2015 | Colorectal Dis2015，17，5： | 1 |
| 20 | MultiLoe: prediction of protein subeellular localization using N-terminal targeting sequences, sequence motifs and amino acid composition 显示文摘 | Hoglund A Donnes P Blum T | 2006 | Bioinformaties2006，22，10： | 1 |
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