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| 1 | Chronic antiepileptic drug use and functional network efficiency: A functional magnetic resonance imaging study显示文摘AIM To increase our insight in the neuronal mechanisms underlying cognitive side-effects of antiepileptic drug(AED) treatment.METHODS The relation between functional magnetic resonance-acquired brain network measures, AED use, and cognitive function was investigated. Three groups of patients with epilepsy with a different risk profile for developing cognitive side effects were included: A 'low risk' category(lamotrigine or levetiracetam, n=16), an 'intermediate risk' category(carbamazepine, oxcarbazepine, phenytoin, or valproate, n=34) and a 'high risk' category(topiramate, n=5). Brain connectivity was assessed using resting state functional magnetic resonance imaging and graph theoretical network analysis. The Computerized Visual Searching Task was used to measure central information processing speed, a common cognitive side effect of AED treatment. RESULTS Central information processing speed was lower in patients taking AEDs from the intermediate and high risk categories, compared with patients from the low risk category. The effect of risk category on global efficiency was significant(P < 0.05, ANCOVA), with a significantly higher global efficiency for patient from the low category compared with the high risk category(P < 0.05, post-hoc test). Risk category had no significant effect on the clustering coefficient(ANCOVA, P > 0.2). Also no significant associations between information processing speed and global efficiency or the clustering coefficient(linear regression analysis, P > 0.15) were observed. CONCLUSION Only the four patients taking topiramate show aberrant network measures, suggesting that alterations in functional brain network organization may be only subtle and measureable in patients with more severe cognitive side effects. | Tamar M van Veenendaal Dominique M IJff Albert P Aldenkamp Richard H C Lazeron Paul A M Hofman Anton J A de Louw Walter H Backes Jacobus F A Jansen | 2017 | World Journal of Radiology2017，9，6： | 2 |
| 2 | The use of biological activated carbon filtration for the removal of natural organic matter and organic micropollutants from water 显示文摘 | J P van der Hoek J A M H Hofman A Graveland | 1999 | Water Science and Technology1999，40，9： | 1 |
| 3 | Endothelin- 1 induces production of the neutrophil chemotactic factor interleukin - 8 by human brain - derived endothelial cells 显示文摘 | Chen P Jeyaseelan R | 1998 | Blood1998，92，9： | 1 |
| 4 | Elec trical conductivities in oil-bearing shaly sand accurately described with the SATORI saturation model显示文摘 | De Kuijper A Sandor R K J Hofman J P | 1996 | The Log Analyst1996，37，5： | 1 |
| 5 | A practical approach to obtain primary drainagecapillary pressure curves from NMR core and log data显示文摘 | HOFMAN J P LOOYESTIJN W J SLIJKERMAN W F | 2001 | Petrophysics2001，42，4： | 1 |
| 6 | Duration of antihypertensive drug use and risk of dementia: A prospective cohort study 显示文摘 | M D M Haag A Hofman P J Koudstaal | 2009 | Neurology2009，，72： | 1 |
| 7 | Long term capacity of biological activated carbon filtration for organics removal 显示文摘 | Bonne P A C Hofman J A M H van der Hoek J P | 2002 | Water Supply2002，2，1： | 1 |
| 8 | Influence of daily setup measurements and corrections on the estimated delivered dose during IMRT treatment of prostate cancer patients显示文摘 | VanHaaren PM Bel A Hofman P | 2009 | Radiother Oncol2009，90，3： | 1 |
| 9 | Limitations of routine spiral computerized tomography in the evaluation of blunt renal trauma 显示文摘 | Browns L Hofman DM Spimak J P | 1998 | Urology1998，160，6： | 1 |
| 10 | Human polymorphonuclear leukocytes are sensitive in vitro to Helicobacter pylori VacA toxin显示文摘 | Brest P Hofman V Lassalle S | 2006 | Helicobacter2006，11，6： | 1 |
| 11 | Ripening and quality responses of avocado,custard apple,mango and papaya fruit to 1-methylcyclopropene显示文摘 | Hofman P J Jobin-Décor M Meiburg G F | 2001 | Australian Journal of Experimental Agriculture2001，41，4： | 1 |
| 12 | Endocrine disruptors and the thyroid gland: a combined in vitro and in vivo analysis of potential new biomarkers 显示文摘 | SCHMUTZLER C GOTTHARDT I HOFMAN P J | 2007 | Environ Health Perspect2007，1151，： | 1 |
| 13 | Ripening and quality responses of avocado, custardapple, mango and papaya fruit tol-MCP显示文摘 | Hofman P J Jobin D M Meiburg G F | 2001 | Australian Journal of Experiment Agriculture2001，41，： | 1 |
| 14 | Low temperature conditioning before cold disinfestation improves 'Hass' avocado fruit quality显示文摘 | Hofman P J Stubbings B A Adkins M F | 2003 | Postharvest Biology and Technology2003，28，1： | 1 |
| 15 | Migraine as a risk factor for subclinical brain lesions显示文摘 | Kruit M C van Buchem M A Hofman P A | 2004 | JAMA2004，291，： | 1 |
| 16 | Temporal and spatial patterns of denitrifycation enzyme activity and nitrous oxide fluxes in three adjacent vegetated riparian buffer zones 显示文摘 | DHONDT K BOECKX P HOFMAN G | 2004 | Biology and Fertility of Soils2004，40，： | 1 |
| 17 | Segmentalhyperperfusion in lobar pneumonia visualized withrespiratory-gated four-dimensional pulmonary perfusionpositron emission tomography-computed tomography显示文摘 | Hofman MS Cal lahan J Eu P | 2014 | AmJ Respir Crit Care Med2014，189，1： | 1 |
| 18 | Skp1 connects cell cycle regulation to the ubiquitin proteolysis machinery through a novel motif,the F-box显示文摘 | Bai C Sen P Hofman K | 1996 | Cell1996，86，： | 1 |
| 19 | Effect of preharvest bagging and of embryo abortion on calcium levels in 'Kensington Pride' mango fruit显示文摘 | HOFMAN P J BEASLEY D R JOYCE D C | 1999 | Aust J Exp Agr1999，39，3： | 1 |
| 20 | Quantification of orbit- al and midfacial growth retardation after megavoltage external beam irradiation in children with retinoblastoma 显示文摘 | Imhof S M Mourits M P Hofman P | 1996 | Ophthalmology1996，103，2： | 1 |
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