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| 1 | Pathobiology of the neutrophil-intestinal epithelial cell interaction:Role in carcinogenesis显示文摘The role of chronic inflammation,acting as an independent factor,on the onset of gastrointestinal carcinogenesis is now well accepted.However,even if there is an increase in the number of elements directly involving polymorphonuclear leukocytes (PMNL),as a major actor in digestive carcinogenesis,the different cellular and molecular events occurring in this process are still not completely understood.The transepithelial migration of PMNL,which is the ultimate step of the afflux of PMNL into the digestive mucosa,is a complex phenomenon involving sequential interaction of molecules expressed both on PMNL and on digestive epithelial cells.Chronic inflammatory areas rich in PMNL [so-called (chronic active inflammation)] and iterative transepithelial migration of PMNL certainly evoke intracellular signals,which lead toward progressive transformation of epithelia.Among these different signals,the mutagenic effect of reactive oxygen species and nitrates,the activation of the nuclear factor-κB pathway,and the modulation of expression of certain microRNA are key actors.Following the initiation of carcinogenesis,PMNL are involved in the progression and invasion of digestive carcinomas,with which they interact.It is noteworthy that different subpopulations of PMNL,which can have some opposite effects on tumor growth,in association with different levels of transforming growth factor-β and with the number of CD8 positive T lymphocytes,could be present during the development of digestive carcinoma.Other factors that involve PMNL,such as massive elastase release,and the production of angiogenic factors,can participate in the progression of neoplastic cells through tissues.PMNL may play a major role in the onset of metastases,since they allow the tumor cells to cross the endothelial barrier and to migrate into the blood stream.Finally,PMNL play a role,alone or in association with other cell parameters,in the initiation,promotion,progression and dissemination of digestive carcinomas.This review focuses on the main currently accepted cellular and molecular mechanisms that involve PMNL as key actors in digestive carcinogenesis. | Paul M Hofman | 2010 | World Journal of Gastroenterology2010，16，46： | 9 |
| 2 | Chronic antiepileptic drug use and functional network efficiency: A functional magnetic resonance imaging study显示文摘AIM To increase our insight in the neuronal mechanisms underlying cognitive side-effects of antiepileptic drug(AED) treatment.METHODS The relation between functional magnetic resonance-acquired brain network measures, AED use, and cognitive function was investigated. Three groups of patients with epilepsy with a different risk profile for developing cognitive side effects were included: A 'low risk' category(lamotrigine or levetiracetam, n=16), an 'intermediate risk' category(carbamazepine, oxcarbazepine, phenytoin, or valproate, n=34) and a 'high risk' category(topiramate, n=5). Brain connectivity was assessed using resting state functional magnetic resonance imaging and graph theoretical network analysis. The Computerized Visual Searching Task was used to measure central information processing speed, a common cognitive side effect of AED treatment. RESULTS Central information processing speed was lower in patients taking AEDs from the intermediate and high risk categories, compared with patients from the low risk category. The effect of risk category on global efficiency was significant(P < 0.05, ANCOVA), with a significantly higher global efficiency for patient from the low category compared with the high risk category(P < 0.05, post-hoc test). Risk category had no significant effect on the clustering coefficient(ANCOVA, P > 0.2). Also no significant associations between information processing speed and global efficiency or the clustering coefficient(linear regression analysis, P > 0.15) were observed. CONCLUSION Only the four patients taking topiramate show aberrant network measures, suggesting that alterations in functional brain network organization may be only subtle and measureable in patients with more severe cognitive side effects. | Tamar M van Veenendaal Dominique M IJff Albert P Aldenkamp Richard H C Lazeron Paul A M Hofman Anton J A de Louw Walter H Backes Jacobus F A Jansen | 2017 | World Journal of Radiology2017，9，6： | 2 |
| 3 | The use of biological activated carbon filtration for the removal of natural organic matter and organic micropollutants from water 显示文摘 | J P van der Hoek J A M H Hofman A Graveland | 1999 | Water Science and Technology1999，40，9： | 1 |
| 4 | The Rotterdam Study:2010 objectives and design update显示文摘 | HOFMAN A BRETELER M M VAN DUIJN C M | 2009 | Eur J Epidemiol2009，24，9： | 1 |
| 5 | Absence of a prominent TH2 cytokine response in human tuberculosis 显示文摘 | Lin Y Zhang M Hofman FM PanX | 1996 | Infect Immun1996，64，： | 1 |
| 6 | Duration of antihypertensive drug use and risk of dementia: A prospective cohort study 显示文摘 | M D M Haag A Hofman P J Koudstaal | 2009 | Neurology2009，，72： | 1 |
| 7 | Long term capacity of biological activated carbon filtration for organics removal 显示文摘 | Bonne P A C Hofman J A M H van der Hoek J P | 2002 | Water Supply2002，2，1： | 1 |
| 8 | LANA-1 ,Bcl-2,Mcl-1 and HIF-I alpha protein expression in HIV-associated Kaposi sarcoma 显示文摘 | Long E fllie M Hofman V | 2009 | Virchows Arch2009，455，2： | 1 |
| 9 | Problem-based learning out-comesten years of experience at the University of Missouri-Coloumbia School of Medieine 显示文摘 | Hofman K Hosokawa M Blake RJ | 2006 | Acad Med2006，81，7： | 1 |
| 10 | Cancer- related Fatigue: the Scale of the Problem显示文摘 | Hofman M Ryan J L Figueroa-Moseley C D | 2007 | Oncologist2007，12，1： | 1 |
| 11 | Low-temperature irradiation behavior of ura nium-molybdenum alloy dispersion fuel显示文摘 | MEYER M K HOFMAN G L HAYES S L | 2002 | Jour nal of Nuclear Materials2002，304，： | 1 |
| 12 | Coronary calcification improves cardiovascular risk prediction in the elderly显示文摘 | Oudkerk M Hofman A | 2005 | Circulation2005，112，4： | 1 |
| 13 | Atherosclerosis,apolipoprotein E,and prevalence of dementia and Alzheimer's disease in the Rotterdam Study显示文摘 | Hofman A Ott A Breteler M | | 0，，： | 1 |
| 14 | Uric acid is a risk factor for myocardial infarction and stroke: the Rotterdam study 显示文摘 | Bos M J Koudstaal PJ Hofman A | 2006 | Stroke2006，37，6： | 1 |
| 15 | Measuring the contribution of tumor biobanks to research in oncology:surrogate indicators and bibliographic output显示文摘 | Hofman V Ilie M Long E | 2013 | Biopreserv Biobank2013，11，4： | 1 |
| 16 | Problem - based learning out - comes: ten years of experience at the University of Missouri- Columbia School of Medieine显示文摘 | Hofman K Hosokawa M Blake R J | 2006 | Acad Med2006，81，7： | 1 |
| 17 | Professional identity in institutions of higher learning in Israel显示文摘 | Moore M Hofman J E | 1998 | Higher Education1998，17，1： | 1 |
| 18 | The Metabolic Consequences of Low and Moderate Intensity Exercise with or with or without Feeding in Lean and Borderline Obese Males显示文摘 | C E BROEDER M BRENNER Z HOFMAN | 1991 | Int J Obes1991，15，： | 1 |
| 19 | Ripening and quality responses of avocado,custard apple,mango and papaya fruit to 1-methylcyclopropene显示文摘 | Hofman P J Jobin-Décor M Meiburg G F | 2001 | Australian Journal of Experimental Agriculture2001，41，4： | 1 |
| 20 | New phacoemulsification technologies 显示文摘 | Fine IH Packer M Hofman RS | 2002 | Cataract Refract Surg2002，28，6： | 1 |
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