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| 1 | Chronic antiepileptic drug use and functional network efficiency: A functional magnetic resonance imaging study显示文摘AIM To increase our insight in the neuronal mechanisms underlying cognitive side-effects of antiepileptic drug(AED) treatment.METHODS The relation between functional magnetic resonance-acquired brain network measures, AED use, and cognitive function was investigated. Three groups of patients with epilepsy with a different risk profile for developing cognitive side effects were included: A 'low risk' category(lamotrigine or levetiracetam, n=16), an 'intermediate risk' category(carbamazepine, oxcarbazepine, phenytoin, or valproate, n=34) and a 'high risk' category(topiramate, n=5). Brain connectivity was assessed using resting state functional magnetic resonance imaging and graph theoretical network analysis. The Computerized Visual Searching Task was used to measure central information processing speed, a common cognitive side effect of AED treatment. RESULTS Central information processing speed was lower in patients taking AEDs from the intermediate and high risk categories, compared with patients from the low risk category. The effect of risk category on global efficiency was significant(P < 0.05, ANCOVA), with a significantly higher global efficiency for patient from the low category compared with the high risk category(P < 0.05, post-hoc test). Risk category had no significant effect on the clustering coefficient(ANCOVA, P > 0.2). Also no significant associations between information processing speed and global efficiency or the clustering coefficient(linear regression analysis, P > 0.15) were observed. CONCLUSION Only the four patients taking topiramate show aberrant network measures, suggesting that alterations in functional brain network organization may be only subtle and measureable in patients with more severe cognitive side effects. | Tamar M van Veenendaal Dominique M IJff Albert P Aldenkamp Richard H C Lazeron Paul A M Hofman Anton J A de Louw Walter H Backes Jacobus F A Jansen | 2017 | World Journal of Radiology2017，9，6： | 2 |
| 2 | The use of biological activated carbon filtration for the removal of natural organic matter and organic micropollutants from water 显示文摘 | J P van der Hoek J A M H Hofman A Graveland | 1999 | Water Science and Technology1999，40，9： | 1 |
| 3 | Epistatic effect of cholesteryl ester transfer protein and hepatic lipase on serum high-density lipoprotein cholesterol levels 显示文摘 | Isaacs A Aulchenko YS Hofman A | 2007 | J Clin Endocrinol Metab2007，92，7： | 1 |
| 4 | Antihy- pertensive drugs and incidence of dementia: the Rotter- dam Study 显示文摘 | Bint Veld BYA Ruitenberg A Hofman A | 2001 | Nettrobiol Aging2001，，22： | 1 |
| 5 | The Rotterdam Study:2010 objectives and design update显示文摘 | HOFMAN A BRETELER M M VAN DUIJN C M | 2009 | Eur J Epidemiol2009，24，9： | 1 |
| 6 | Arterial stiffness and risk of cor onary heart disease and stroke: the Rotter-dam Study 显示文摘 | MATTACE RASO F U VAN DER CAMMEN T J HOFMAN A | 2006 | Circulation2006，113，： | 1 |
| 7 | At what age is the developing cerebral cortex of the rat comparable to that of the full-term human baby显示文摘 | ROMIJN HJ HOFMAN MA GRAMSBERGEN A | 1991 | Early Hum Dev1991，26，： | 1 |
| 8 | Addressing the growing burden of trauma and injury in low-and middle-income countries显示文摘 | Hofman K Primack A Keusch G | 2005 | Am J Public Health2005，95，1： | 1 |
| 9 | Elec trical conductivities in oil-bearing shaly sand accurately described with the SATORI saturation model显示文摘 | De Kuijper A Sandor R K J Hofman J P | 1996 | The Log Analyst1996，37，5： | 1 |
| 10 | Duration of antihypertensive drug use and risk of dementia: A prospective cohort study 显示文摘 | M D M Haag A Hofman P J Koudstaal | 2009 | Neurology2009，，72： | 1 |
| 11 | Long term capacity of biological activated carbon filtration for organics removal 显示文摘 | Bonne P A C Hofman J A M H van der Hoek J P | 2002 | Water Supply2002，2，1： | 1 |
| 12 | Nonsteroidal antiinflammatory drugs and the risk of Alzheimer′s disease显示文摘 | in t′Veld BA Ruitenberg A Hofman A Launer LJ van Duijn CM Stijnen T | 2001 | N Engl J Med2001，345，21： | 1 |
| 13 | Influence of daily setup measurements and corrections on the estimated delivered dose during IMRT treatment of prostate cancer patients显示文摘 | VanHaaren PM Bel A Hofman P | 2009 | Radiother Oncol2009，90，3： | 1 |
| 14 | Cross-sectionally assessed carotid intima-media thickness relates to longtenn risk of stroke ,coronary heart disease and death as estimated by available risk functions 显示文摘 | Bots ML Hoes AW Hofman A | 1999 | Intern Med1999，245，3： | 1 |
| 15 | Coronary calcification improves cardiovascular risk prediction in the elderly显示文摘 | Oudkerk M Hofman A | 2005 | Circulation2005，112，4： | 1 |
| 16 | Uirc acid is a risk factor of myocardial infarction and stroke:The Rotterdam study显示文摘 | Bos MJ Koudstaal PJ Hofman A | 2006 | Stroke2006，37，6： | 1 |
| 17 | Arterial stiffness and risk of coronary heart disease and stroke:the rotterdam study显示文摘 | Mattace-Raso F U van der Cammen T J Hofman A | 2006 | Circulation2006，113，： | 1 |
| 18 | Atherosclerosis,apolipoprotein E,and prevalence of dementia and Alzheimer's disease in the Rotterdam Study显示文摘 | Hofman A Ott A Breteler M | | 0，，： | 1 |
| 19 | Uric acid is a risk factor for myocardial infarction and stroke: the Rotterdam study 显示文摘 | Bos M J Koudstaal PJ Hofman A | 2006 | Stroke2006，37，6： | 1 |
| 20 | A study of gene-environment interaction on the gene for angiotensin converting enzyme:a combined functional and population based approach显示文摘 | Sayed-Tabatabaei FA Schut AF Hofman A | 2004 | J Med Genet2004，41，2： | 1 |
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