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| 1 | Adenosquamous carcinoma of the pancreas: Molecular characterization of 23 patients along with a literature review显示文摘Adenosquamous carcinoma of the pancreas(ASCP)is a rare entity. Like adenocarcinoma of the pancreas,overall survival is poor. Characteristics of ASCP include central tumor necrosis, along with osteoclasts and hypercalcemia. Various theories exist as to why this histological subtype exists, as normal pancreas tissue has no benign squamous epithelium. Due to the rarity of this disease, limited molecular analysis has been performed, and those reports indicate unique molecular features of ASCP. In this paper, we characterize 23 patients diagnosed with ASCP through molecular profiling using immunohistochemistry staining, fluorescent in situ hybridization, chromogenic in situ hybridization, and gene sequencing, Additionally, we provide a comprehensive literature review of what is known to date of ASCP.Molecular characterization revealed overexpression in MRP1(80%), MGMT(79%), TOP2A(75), RRM1(42%),TOPO1(42%), PTEN(45%), CMET(40%), and C-KIT(10%) among others. One hundred percent of samples tested were positive for KRAS mutations. This analysis shows heretofore unsuspected leads to be considered for treatments of this rare type of exocrine pancreas cancer. Molecular profiling may be appropriate to provide maximum information regarding the patient's tumor. Further work should be pursued to better characterize this disease. | Erkut Borazanci Sherri Z Millis Ron Korn Haiyong Han Clifford J Whatcott Zoran Gatalica Michael T Barrett Derek Cridebring Daniel D Von Hoff | 2015 | World Journal of Gastrointestinal Oncology2015，7，9： | 6 |
| 2 | Favorable lifestyle before diagnosis associated with lower risk of screen-detected advanced colorectal neoplasia显示文摘AIM: To investigate the association between adherence to health recommendations and detection of advanced colorectal neoplasia(ACN) in colorectal cancer(CRC) screening.METHODS: A total of 14832 women and men were invited to CRC screening, 6959 in the fecal immunochemical test arm and 7873 in the flexible sigmoidoscopy arm. These were also sent a self-reported lifestyle questionnaire to be completed prior to their first CRC screening. A lifestyle score was created to reflect current adherence to healthy behaviors in regard to smoking, body mass index, physical activity, alcohol consumption and food consumption, and ranged from zero(poorest) to six(best). Odds ratios(ORs) and 95%CIs were calculated using multivariable logistic regression to evaluate the association between the single lifestyle variables and the lifestyle score and the probability of detecting ACN.RESULTS: In all 6315 women and men completed the lifestyle questionnaire, 3323(53%) in the FIT arm and 2992(47%) in the FS arm. This was 89% of those who participated in screening. ACN was diagnosed in 311(5%) participants of which 25(8%) were diagnosed with CRC. For individuals with a lifestyle score of two, three, four, and five-six, the ORs(95%CI) for the probability of ACN detection were 0.82(0.45-1.16), 0.43(0.28-0.73), 0.41(0.23-0.64), and 0.41(0.22-0.73), respectively compared to individuals with a lifestyle score of zero-one. Of the single lifestyle factors, adherence to non-smoking and moderate alcohol intake were associated with a decreased probability of ACN detection compared to being a smoker or having a high alcohol intake 0.53(0.42-0.68) and 0.63(0.43-0.93) respectively.CONCLUSION: Adopted healthy behaviors were inversely associated with the probability of ACN detection. Lifestyle assessment might be useful for risk stratification in CRC screening. | Markus D Knudsen Thomas de Lange Edoardo Botteri Dung-Hong Nguyen Helge Evensen Chloé B Steen Geir Hoff Tomm Bernklev Anette Hjartaker Paula Berstad | 2016 | World Journal of Gastroenterology2016，22，27： | 3 |
| 3 | Functional Genomics in Plants 显示文摘 | BOUCHEZ D HOFF H | 1998 | Plant Physiology1998，118，： | 1 |
| 4 | The importance of snow scavenging of polychlorinated biphenyl and polycyclic aromatic hydrocarbon vapors 显示文摘 | Wania F Mackay D Hoff J | 1999 | Environ Sci Technol1999，33，1： | 1 |
| 5 | Spherically symmetric solutions of the Navier-Stokes equations for compressible, isothermal flow with large discontinuous initial data 显示文摘 | Hoff D Novotn:: A Petzeltov: H | 1992 | Indiana Univ Math J1992，41，： | 1 |
| 6 | Tumor-stroma interactions in pancre-atic ductal adenocarcinoma显示文摘 | Mahadevan D Von Hoff D D | 2007 | Molecular cancer therapeutics2007，6，4： | 1 |
| 7 | Comparison of in vitro activities of camptothecin and nitidine derivatives against fungal and cancer cells 显示文摘 | Del Poeta M Chen SF Von Hoff D | 1999 | Antimicrob Agents Chemother1999，43，12： | 1 |
| 8 | Modeling dependencies in international relations networks 显示文摘 | Hoff Peter D | 2004 | Political Analysis2004，12，2： | 1 |
| 9 | Uniqueness and continuous depend- ence of weak solutions in compressible magnetohydrody- namics显示文摘 | Hoff D Tsyganov E | 2005 | ZAngew Math Phys2005，56，： | 1 |
| 10 | The importance of snow scavenging of polycyclic aromatic hydrocarbon vapors 显示文摘 | WANIA F MACKAY D HOFF J T | 1998 | Environmental Science and Technology1998，33，： | 1 |
| 11 | Photobiology of micro-organisms: how photosensors catch a photon to initialize signaling 显示文摘 | Hellingwerf K J Hoff W D Crielaard W | 1996 | Mol Microbiol1996，21，： | 1 |
| 12 | Osteopoikilosis aml multiple exostoses caused by novel mutations in LEMD3 and EXTI genes respectively--coinci- dence within one family显示文摘 | Baadanjav S Jamsheer A Kolanczyk M Horn D Latos T Hoff mann K | 2010 | BMC Med Genet2010，11，： | 1 |
| 13 | STUDY OF PT-PROMOTED COBALT CO HYDROGENATION CATALYSTS显示文摘 | Schanke D Vada S Blekkan E A Hilmen A M Hoff A Holmen A | | 0，，： | 1 |
| 14 | The enzyme 4- hydroxy- 2- oxoglutarate aldolase is deficient in primary hyperoxaluria type 3显示文摘 | Williams EL Bockenhauer D van't Hoff WG | 2012 | Nephrol Dial Transplant2012，27，： | 1 |
| 15 | The Arabidopsis downymildew resistance gene RPP8 is induced by pathogens andsalicylic acid and is regulated by W-box cis elements 显示文摘 | Mohr T J Mammarella N D Hoff T | 2010 | MolPlant-Micro Interac2010，23，10： | 1 |
| 16 | Enhancing career development through the career success club显示文摘 | Wessel R D Christian N T Hoff A K | 2003 | Journal of Career Development2003，，29： | 1 |
| 17 | The taxoids: same roots, different drugs显示文摘 | Yon Hoff D D | 1997 | Semin Oncol1997，24，13： | 1 |
| 18 | The failure of continuous dependence on initial data for the Navier-Stokes Equations of compressible flow显示文摘 | Hoff D Serre D | 1991 | SIAM J Appl Math1991，51，4： | 1 |
| 19 | Dynamic imaging of emer-ging resistance during cancer therapy 显示文摘 | Lee K C Hall D E Hoff B A | 2006 | Cancer Res2006，66，9： | 1 |
| 20 | Randomized phase III study of weekly nab - paclitaxel plus gemeitabine versus gemeitabine a- lone in patients with metastatic adenocareinoma of the panceras ( MPACT ) 显示文摘 | Von Hoff D Ervin TJ Arena FP et at | 2012 | Gastrointestinal Cancers Symposium2012，5，： | 1 |
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