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| 1 | Significance of postoperative follow-up of patients with metastatic colorectal cancer using circulating tumor DNA显示文摘BACKGROUND One of the most notable applications for circulating tumor DNA(ctDNA)detection in peripheral blood of patients with metastatic colorectal cancer(mCRC)is a long-term postoperative follow-up.Sometimes referred to as a“liquid(re)biopsy”it is a minimally invasive procedure and can be performed repeatedly at relatively short intervals(months or even weeks).The presence of the disease and the actual extent of the tumor burden(tumor mass)within the patient’s body can be monitored.This is of particular importance,especially when evaluating radicality of surgical treatment as well as for early detection of disease progression or recurrence.AIM To confirm the radicality of surgery using ctDNA and compare available methods for detection of recurrence in metastatic colorectal cancer.METHODSA total of 47 patients with detected ctDNA and indications for resection of mCRC were enrolled in the multicenter study involving three surgical centers.Standard postoperative follow-ups using imaging techniques and the determination of tumor markers were supplemented by ctDNA sampling.In addition to the baseline ctDNA testing prior to surgery,a postoperative observation was conducted by evaluating ctDNA presence up to a week after surgery and subsequently at approximately three-month intervals.The presence of ctDNA was correlated with radicality of surgical treatment and the actual clinical status of the patient.RESULTS Among the monitored patients,the R0(curative)resection correlated with postoperative ctDNA negativity in 26 out of 28 cases of surgical procedures(26/28,93%).In the remaining cases of R0 surgeries that displayed ctDNA,both patients were diagnosed with a recurrence of the disease after 6 months.In 7 patients who underwent an R1 resection,4 ctDNA positivities(4/7,57%)were detected after surgery and associated with the confirmation of early disease recurrence(after 3 to 7 months).All 15 patients(15/15,100%)undergoing R2 resection remained constantly ctDNA positive during the entire follow-up period.In 22 cases of recurrence,ctDNA positivity was detected 22 times(22/22,100%)compared to 16 positives(16/22,73%)by imaging methods and 15 cases(15/22,68%)of elevated tumor markers.CONCLUSION ctDNA detection in patients with mCRC is a viable tool for early detection of disease recurrence as well as for confirmation of the radicality of surgical treatment. | Lucie Benešová Tereza Hálková Renata Ptáčková Anastasiya Semyakina Kateřina Menclová JiříPudil Miroslav Ryska Miroslav Levý JaromírŠimša Filip Pazdírek JiříHoch Milan Blaha Marek Minárik | 2019 | World Journal of Gastroenterology2019，25，48： | 3 |
| 2 | An experimental model for infiltration of malignant lymphoma to the eye and brain显示文摘 | ASSAF N HASSON T HOCH MARCHAIM H | 1997 | Virchows Arch1997，431，6： | 1 |
| 3 | Glomerular injury associated with hepatitis C infection: A correlation with blood and tissue HCV-PCR显示文摘 | Hoch B Juknevicius I Liapis H | 2002 | Semin Diagn Pathol2002，19，3： | 1 |
| 4 | Can fresnoite (Ba2TiSi208) incorporate Ti3+ when crystallizing from highly reduced melts显示文摘 | HOCHE T KLEEBE H J BRYDSON R | 2001 | Philos Mag A2001，81，4： | 1 |
| 5 | Effects of the chromium to aluminum content on the tribology in dry machining using (Cr, A1)N coated tools 显示文摘 | SCHEERER H HOCHE H | 2005 | Surface and Coatings Technology2005，200，： | 1 |
| 6 | Oxidation resistance of SiAlCN:H-coatings显示文摘 | Allebrandt D Hoche H Scheerer H | 2007 | Surface & Coatings Technology2007，201，： | 1 |
| 7 | Development of a plasma surface treatment for magnesium alloys to ensure sufficient wear and corrosion resistance显示文摘 | Hoche H | 2003 | Surface and Coatings Technology2003，173，： | 1 |
| 8 | Heart failure in pediatric patients显示文摘 | Hoch M Netz H | 2005 | Thorac Cardiovasc Surg2005，53，2： | 1 |
| 9 | Effect of Stage 0 Sporulation Mutations on Subtilisin Expression显示文摘 | Ferrari E Howard S M H Hoch J A | 1986 | J Bacteriol1986，166，： | 1 |
| 10 | PTH-receptors regulate norepinephrine retease in human heart and kidney显示文摘 | Potthoff SA Janus A Hoch H | 2011 | Regul Pept2011，171，123： | 1 |
| 11 | Spatial variability of mobile carbohydrates within Pinus cembra trees at the A12 pine treeline显示文摘 | Li M H Hoch G KI rner C H | 2001 | Phyton2001，41，2： | 1 |
| 12 | Differential effects of sterol inhibitors on growth,cell membrane permeability and ultra structure in two target fungi 显示文摘 | DAHMEN H HOCH H C STAUB T | 1988 | Phytopathology1988，78，8： | 1 |
| 13 | Water as the source of oxidant and reductant in bacterial chemosynthesis显示文摘 | ALEEM M I H HOCH G E VARNER J E | 1965 | Biochemistry1965，54，： | 1 |
| 14 | An instrument for measurements of BrO with LED-based Cavity-enhanced differential optical absorption spectroscopy 显示文摘 | HOCH D J BUXMANN J SIHLER H | 2014 | Atmospheric Measurement Techniques2014，7，19： | 1 |
| 15 | Distribution of antibodies to porcine circovirus in swine populations of different breeding farms显示文摘 | Tischer H Vettermann W Hoch M A | 1995 | Arch Virol1995，140，： | 1 |
| 16 | Plasma anodisation as an environmental harmless method for the corrosion protection of magnesium alloys显示文摘 | HOCHE H SCHEERER H PROBST D | 2003 | Surface and Coatings Technology2003，，： | 1 |
| 17 | Investigation of the macroscopic and microscopic electrochemical corrosion behavior of PVD-coated magnesium die cast alloy AZ91显示文摘 | HOCHE H ROSENKRANZ C DELP A | 2005 | Surface and Coatings Technology2005，193，： | 1 |
| 18 | Souce/sink removal affects mobile carbohydrates in Pinus cembra at the Swiss treeline 显示文摘 | Li M H Hoch G Komer C | 2002 | Trees2002，16，： | 1 |
| 19 | Tribological properties of sputtered CrN coatings under dry sliding oscillation motion at elevated temperatures显示文摘 | Scheerer H Hoche H Broszeit E | 2001 | Surface and Coatings Technology2001，，： | 1 |
| 20 | Spatial variability of mobile carbohydrates within Pinus cembra trees at the Alpine treeline 显示文摘 | LI M H HOCH G KORNER C | 2001 | Phyton2001，41，2： | 1 |
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