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| 1 | Significance of postoperative follow-up of patients with metastatic colorectal cancer using circulating tumor DNA显示文摘BACKGROUND One of the most notable applications for circulating tumor DNA(ctDNA)detection in peripheral blood of patients with metastatic colorectal cancer(mCRC)is a long-term postoperative follow-up.Sometimes referred to as a“liquid(re)biopsy”it is a minimally invasive procedure and can be performed repeatedly at relatively short intervals(months or even weeks).The presence of the disease and the actual extent of the tumor burden(tumor mass)within the patient’s body can be monitored.This is of particular importance,especially when evaluating radicality of surgical treatment as well as for early detection of disease progression or recurrence.AIM To confirm the radicality of surgery using ctDNA and compare available methods for detection of recurrence in metastatic colorectal cancer.METHODSA total of 47 patients with detected ctDNA and indications for resection of mCRC were enrolled in the multicenter study involving three surgical centers.Standard postoperative follow-ups using imaging techniques and the determination of tumor markers were supplemented by ctDNA sampling.In addition to the baseline ctDNA testing prior to surgery,a postoperative observation was conducted by evaluating ctDNA presence up to a week after surgery and subsequently at approximately three-month intervals.The presence of ctDNA was correlated with radicality of surgical treatment and the actual clinical status of the patient.RESULTS Among the monitored patients,the R0(curative)resection correlated with postoperative ctDNA negativity in 26 out of 28 cases of surgical procedures(26/28,93%).In the remaining cases of R0 surgeries that displayed ctDNA,both patients were diagnosed with a recurrence of the disease after 6 months.In 7 patients who underwent an R1 resection,4 ctDNA positivities(4/7,57%)were detected after surgery and associated with the confirmation of early disease recurrence(after 3 to 7 months).All 15 patients(15/15,100%)undergoing R2 resection remained constantly ctDNA positive during the entire follow-up period.In 22 cases of recurrence,ctDNA positivity was detected 22 times(22/22,100%)compared to 16 positives(16/22,73%)by imaging methods and 15 cases(15/22,68%)of elevated tumor markers.CONCLUSION ctDNA detection in patients with mCRC is a viable tool for early detection of disease recurrence as well as for confirmation of the radicality of surgical treatment. | Lucie Benešová Tereza Hálková Renata Ptáčková Anastasiya Semyakina Kateřina Menclová JiříPudil Miroslav Ryska Miroslav Levý JaromírŠimša Filip Pazdírek JiříHoch Milan Blaha Marek Minárik | 2019 | World Journal of Gastroenterology2019，25，48： | 3 |
| 2 | Tumor necrosis factor-alpha in macrophages of heart,liver,kidney and in the pituitary gland显示文摘 | ARRAS MA HOCHE R BOHLE | 1996 | Cell Tissue Res1996，285，： | 1 |
| 3 | Can fresnoite (Ba2TiSi208) incorporate Ti3+ when crystallizing from highly reduced melts显示文摘 | HOCHE T KLEEBE H J BRYDSON R | 2001 | Philos Mag A2001，81，4： | 1 |
| 4 | Composition controlled spin polarization in Co1-x FexS2 alloys 显示文摘 | C Leighton M Manno A Cady J W Freeland L Wang K Umenoto R M Wentzcovitch T Y Chen C L Chien P L Kuhns M J R Hoch A P Reyes W G Moulton E D Dahlberg J Checkelsky J Eckert | 2007 | Journal of Physics : Condensed Matter2007，19，31： | 1 |
| 5 | Differential screening and suppression subtractive hybrization identified genes differentially expressed in an estrogen receptor-positive breast carcinoma cell line显示文摘 | Kuang W W Thompson D A Hoch R V | 1998 | Nucleic Acids Res1998，26，4： | 1 |
| 6 | New observa- tions with the gas electron multiplier(GEM) 显示文摘 | Bouclier R Dominik W Hoch M | 1997 | Nu- clear Instruments and Methods in Physics Research A1997，396，12： | 1 |
| 7 | High power electro-chemical capacitors based on carbon nanotube electrodes显示文摘 | Niu C Sichel E K Hoch R | 1997 | Appl Phys Lett1997，，： | 1 |
| 8 | Calcite crystal growth rate inhibition by polycarboxylicacid显示文摘 | Reddy M M Hoch A R | | 0，，： | 1 |
| 9 | Diverse antibody recognition patterns of the multiple Sm-D antigen polypeptides显示文摘 | HOCH S O ELSENBERG R A SHARP G C | 1999 | Clini Immunol1999，92，2： | 1 |
| 10 | High power electrochemical capacitors based on carbon nanotube electrodes显示文摘 | NIU C SICHEL E K HOCH R | 1997 | Appl Phys Lett1997，70，11： | 1 |
| 11 | Editing of a chloroplast mRNA by creation of an initiation codon显示文摘 | HOCH B Maier R M Appel K | 1991 | Nature1991，353，： | 1 |
| 12 | Differential screening and suppression subtractive hybridization identified genes differentially expressed in an estrogen receptor-positive breast carcinoma cell line显示文摘 | Kuang W W Thompson D A Hoch R V | 1998 | Nucleic Acids Research1998，26，4： | 1 |
| 13 | P16 expression predicts necrotic re- sponse among patients with osteosarcoma receiving neoadjuvant chemo- therapy显示文摘 | Borys D Canter R J Hoch B | 2012 | Hum Patho12012，43，11： | 1 |
| 14 | Nasal CPAP: An objective evalua- tion of patient compliance显示文摘 | Reeves - Hoche MK Meck R | 1994 | Am J Respir Crit Care Med1994，149，1： | 1 |
| 15 | Database models and manageri- al intuition: 50% model + 50% manager显示文摘 | Blattberg R C Hoch S J | 1990 | Manage- ment Science1990，36，： | 1 |
| 16 | Roles of PDGF in animal development 显示文摘 | Hoch R V Soriano P | 2003 | Development2003，130，： | 1 |
| 17 | High power electrochemical capacitors based on carbon nanotube electrodes显示文摘 | Niu C M Sichel E K Hoch R | 1997 | Applied Physics Letters1997，70，： | 1 |
| 18 | High power electrochemical capacitors based on carbon nanotube electrodes显示文摘 | Niu C Sichel E K Hoch R | 1997 | Appl Phys Lett1997，70，： | 1 |
| 19 | High power electrochemical capacitors based on carbon nanotube electrodes显示文摘 | Niu C M Sichel E K Hoch R | 1997 | Applied Physics Letters1997，70，11： | 1 |
| 20 | High power electrochemical capacitors based on carbon nanotube electrodes显示文摘 | NIU C SICHEL E K HOCH R | 1997 | Appy Phys Lett1997，70，11： | 1 |
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