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| 1 | 4-1BB signaling activates glucose and fatty acid metabolism to enhance CD8^(+) T cell proliferation显示文摘4-1BB(CD137)is a strong enhancer of the proliferation of CD8^(+)T cells.Since these cells require increased production of energy and biomass to support their proliferation,we hypothesized that 4-1BB signaling activated glucose and fatty acid metabolism.We found that treatment with agonistic anti-4-1BB mAb promoted the proliferation of CD8^(+)T cells in vitro,increasing their size and granularity.Studies with a glycolysis inhibitor and a fatty acid oxidation inhibitor revealed that CD8^(+)T cell proliferation required both glucose and fatty acid metabolism.Anti-4-1BB treatment increased glucose transporter 1 expression and activated the liver kinase B1(LKB1)-AMP-activated protein kinase(AMPK)-acetyl-CoA carboxylase(ACC)signaling pathway,which may be responsible for activating the metabolism of glucose and fatty acids.We also examined whether blocking glucose or fatty acid metabolism affected cell cycle progression and the anti-apoptotic effect of 4-1BB signaling.The increase of anti-apoptotic factors and cyclins in response to anti-4-1BB treatment was completely prevented by treating CD8^(+)T cells with the fatty acid oxidation inhibitor,etomoxir,but not with the glycolysis inhibitor,2-deoxy-D-glucose.We conclude that anti-4-1BB treatment activates glucose and fatty acid metabolism thus supporting the increased demand for energy and biomass,and that fatty acid metabolism plays a crucial role in enhancing the cell cycle progression of anti-CD3-activated CD8^(+)T cells in vitro and the anti-apoptotic effects of 4-1BB signaling on these cells. | Beom K Choi Do Y Lee Don G Lee Young H Kim Seon-Hee Kim Ho S Oh Chungyong Han Byoung S Kwon | 2017 | Cellular & Molecular Immunology2017，14，9： | 6 |
| 2 | 临床前肥厚型心肌病的临床表现谱:肌小节基因突变携带者的特征显示文摘肥厚型心肌病研究历史已有50余年,近年研究发现:(1)50%~70%的肥厚型心肌病由基因突变所致,基因诊断已经获美国FDA批准,使临床前诊断成为可能。(2)置入性心脏除颤器的临床应用,挽救了一大批有猝死危险的肥厚型心肌病患者,使大多数患者的寿命几乎与正常人相同。 | Carolyn Y Ho | 2009 | 中华心血管病杂志2009，37，4： | 2 |
| 3 | Colonic motility abnormality in patients with irritable bowel syndrome exhibiting abdominal pain and diarrhea显示文摘 | William Y Chey Hai Ou Jin Mun Ho Lee Sung Wu Sun Kae Yol Lee | 2001 | The American Journal of Gastroenterology2001，，5： | 2 |
| 4 | Assessment of menopause-induced myocardial changes by integrated backscatter during inotropic stimulation and atropine injection显示文摘 | HO Y L LIN L C YEN M L | 2002 | Ultrasound Med Biol2002，28，7： | 2 |
| 5 | Risk stratification in symptomatic intracranial atherosclerotic disease with conventional vascular risk factors and cerebral haemodynamics显示文摘Background and purpose Symptomatic intracranial atherosclerotic stenosis(sICAS)is associated with a considerable risk of recurrent stroke despite contemporarily optimal medical treatment.Severity of luminal stenosis in sICAS and its haemodynamic significance quantified with computational fluid dynamics(CFD)models were associated with the risk of stroke recurrence.We aimed to develop and compare stroke risk prediction nomograms in sICAS,based on vascular risk factors and these metrics.Methods Patients with 50%-99%sICAS confirmed in CT angiography(CTA)were enrolled.Conventional vascular risk factors were collected.Severity of luminal stenosis in sICAS was dichotomised as moderate(50%-69%)and severe(70%-99%).Translesional pressure ratio(PR)and wall shear stress ratio(WSSR)were quantified via CTA-based CFD modelling;the haemodynamic status of sICAS was classified as normal(normal PR&WSSR),intermediate(otherwise)and abnormal(abnormal PR&WSSR).All patients received guideline-recommended medical treatment.We developed and compared performance of nomograms composed of these variables and independent predictors identified in multivariate logistic regression,in predicting the primary outcome,recurrent ischaemic stroke in the same territory(SIT)within 1 year.Results Among 245 sICAS patients,20(8.2%)had SIT.The D2H2A nomogram,incorporating diabetes,dyslipidaemia,haemodynamic status of sICAS,hypertension and age≥50 years,showed good calibration(P for Hosmer-Lemeshow test=0.560)and discrimination(C-statistic 0.73,95%CI 0.60 to 0.85).It also had better performance in risk reclassification and provided larger net benefits in decision curve analysis,compared with nomograms composed of conventional vascular risk factors only,and plus the severity of luminal stenosis in sICAS.Sensitivity analysis in patients with anterior-circulation sICAS showed similar results.Conclusions The D2H2A nomogram,incorporating conventional vascular risk factors and the haemodynamic significance of sICAS as assessed in CFD models,could be a useful tool to stratify sICAS patients for the risk of recurrent stroke under contemporarily optimal medical treatment. | Xuan Tian Hui Fang Linfang Lan Hing Lung Ip Jill Abrigo Haipeng Liu Lina Zheng Florence S Y Fan Sze Ho Ma Bonaventure Ip Bo Song Yuming Xu Jingwei Li Bing Zhang Yun Xu Yannie O Y Soo Vincent Mok Ka Sing Wong Thomas W Leung Xinyi Leng | 2023 | Stroke & Vascular Neurology2023，8，1： | 2 |
| 6 | Oxidation behavior of diamond-like carbon films 显示文摘 | Wang D Y Chang C L Ho W Y | 1999 | Surface and Coatings Technology1999，120，： | 2 |
| 7 | Hair dyes are mutagenic identification of a variety of mutagenic components显示文摘 | Ames BN Kammen HO Edith Y | 1975 | Proc Natl Sci USA1975，72，： | 2 |
| 8 | High prevalence of inducible erythromycin resistance among Streptococcus bovis isolates in Taiwan 显示文摘 | Uh Y Hsueh PR Ho SW | 2004 | Antimicrob Agents Chemother2004，53，6： | 1 |
| 9 | CD95 (Fas)-dependen elimination of self-reactive B cells upon interaction with CD4+T cells 显示文摘 | Rathmell JC Cooke M P Ho W Y et aI | 1995 | Nature1995，376，6536： | 1 |
| 10 | Outcome analysis of intraventricular thrombolytic therapy for intraventricular haemorrhage 显示文摘 | LEE M W PANG K Y HO W W | 2003 | Hong Kong Med J2003，9，5： | 1 |
| 11 | Suppression of lipopolysaccharide- induced nuclear factor- kappaB activity by theaflavin-3,3'-digallate from black tea and other polyphenols through down-regulation of IkappaB kinase activity in macrophages 显示文摘 | Pan M H Lin-shiau S Y Ho C T Lin J H Lin J K | 2000 | Biochem Pharm2000，59，： | 1 |
| 12 | Effect of cilostazol on restenosis after coronary angioplasty and stenting in comparison to conventional coronary artery stenting with ticlopidine 显示文摘 | Tanabe Y ho E Nakagawa I | 2001 | Int J Cardiol2001，78，3： | 1 |
| 13 | The sorption of lead( Ⅱ ) ions on peat显示文摘 | Ho Y S Mekay G | 1999 | Water IRes1999，33，2： | 1 |
| 14 | The US national cholesterol education programe adult treatment panel Ⅲ(NCEPATP Ⅲ) prevalence of the meta bolic syndrome in a Chinese population显示文摘 | THOMAS G N HO S Y JANUS E D | 2005 | Diabetes Res Clin Pract2005，67，： | 1 |
| 15 | Field - amplified sample stacking in capillary electrophoresis for the determination of clozapine, clozapine N - oxide, anddesmethylclozapine in schizophrenics' plasma显示文摘 | Ho Y H Ko W K Kou W S | 2004 | Journal of Chromatography B2004，809，： | 1 |
| 16 | 显示文摘 | Gong H Wilk G D | 2002 | Appl Phys Lett2002，81，： | 1 |
| 17 | Kinetics of pollutant sorption by biosorbents : review 显示文摘 | Ho Y S Ng J C McKay G | 2000 | Sep Purif Methods2000，29，2： | 1 |
| 18 | The prevalence of iron deficiency anemia and its clinical implications in patients with colorectal carcinoma显示文摘 | Ho C H Yu Y B Wu P H | 2008 | J Chin Med Assoc2008，71，3： | 1 |
| 19 | Gaseous and particulate polycyclic aromatic hydrocarbons (PAHs) emissions from Commercial Restaurants in Hong Kong 显示文摘 | Chen Y Ho K F Ho S S | 2007 | Journal of Environment Monitoring2007，9，： | 1 |
| 20 | Improved accuracy of computer --asssisted cervical pediele screw insertion显示文摘 | Kotani Y Abumi K ho M | 2003 | J Neurosurg2003，99，3： | 1 |
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