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| 1 | Bleb needling outcomes for failed trabeculectomy blebs in Asian eyes: a 2-year follow up显示文摘·AIM: To describe the outcomes of bleb needling in primary glaucoma in an Asian tertiary eye centre over a2 y period. To compare the success rates between primary angle-closure glaucoma(PACG) and primary open angle glaucoma(POAG). Lastly, to identify factors associated with success of bleb needling.·METHODS: This was a retrospective review of 227 patients who underwent bleb needling between June2009 and June 2011 in Singapore National Eye Centre.The 5-fluorouracil(5-FU) augmented bleb needling was performed either at the slit lamp or in the operating theatre. Repeat bleb needlings were performed as necessary. Complete success was defined as maintenance of intraocular pressure(IOP) ≥6 mm Hg and ≤21 mm Hg, in the absence of further surgery or use of antiglaucoma medication. Qualified success met the above criteria with or without use of antiglaucoma medications.· RESULTS: One hundred and seventy-five eyes completed the two-year follow up. Sixty-nine percent of participants had POAG and 31% had PACG. The mean interval between filtering surgery and bleb needling was299.9 ±616.4d for POAG and 167.1 ±272.2d for PACG.Mean needling attempts were 1.9±1.4 and 2±1.6 for POAG and PACG respectively. In general, there was a statistically significant reduction of IOP ranging from21.9% to 26.8% from month 1 through to month 24. The complete success rates at month 6 were 70.0% for POAG and 65.7% for PACG. At month 12, this decreased to62.2% for POAG and PACG and at month 24, 57.9% for POAG and 63.0% for PACG respectively. The qualified success rates at month 6 for POAG and PACG were23.8% and 29.9% respectively, 32.2% and 29.2% at month12, and 34.7% and 29.6% at month 24. The success ratesbetween POAG and PACG were not significantly different(P >0.05 for complete and qualified success at months 6,12 and 24). An increased number of needlings and higher pre-needling IOP were associated with failure.·CONCLUSION: The 5-FU augmented bleb needling within one year of trabeculectomy in Asian eyes can provide clinically significant IOP lowering of more than20% for 2y. POAG and PACG had similar complete success rates(58% and 63% respectively). Factors associated with greater risk of procedure failure included increased number of needlings and higher pre-needling IOP. Asian eyes have a greater propensity for scarring but bleb needling, if performed in a timely manner can rescue bleb function. | Andrew S.H.Tsai Pui Yi Boey Hla M Htoon Tina T Wong | 2015 | International Journal of Ophthalmology(English edition)2015，8，4： | 2 |
| 2 | Cyclooxygenase isozymes: the biology of prostaglandin synthesis and inhibition显示文摘 | Simmons DL Botting RM Hla T | 2004 | Pharmacol Rev2004，56，3： | 1 |
| 3 | Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(1) , G(q) , and G(12) families of heterotrimeric G pro- teins显示文摘 | Windh RT Lee M J Hla T | 1999 | J Biol Chem1999，274，27： | 1 |
| 4 | Lysophospholipids-receptor revelations 显示文摘 | Hla T Lee M J Ancellin N | 2001 | Science2001，294，： | 1 |
| 5 | Inhibitory role of sphingosine l- phosphate receptor 2 in macrophage recruitment during inflammation 显示文摘 | Michaud J Im DS Hla T | 2010 | J Immunol2010，184，： | 1 |
| 6 | Cyclooxygenase isozymes: the biology of prostaglandin synthesis and inhibition 显示文摘 | Simmons DL Botting RM Hla T | 2004 | Pharmacol Rev2004，56，3： | 1 |
| 7 | FTY720:sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function显示文摘 | Bripkmann V Cyster JG Hla T | 2004 | Am J Transplant2004，4，7： | 1 |
| 8 | Cyclooxygenase-1 and-2 isoenzymes 显示文摘 | Hla T Bishop-Bailey D Liu CH | 1999 | Int J Biochem Cell Biol1999，31，5： | 1 |
| 9 | Structural and functional characteristics of SIP receptor显示文摘 | Smmhez T Hla T | 2004 | J Cell Biochem2004，92，： | 1 |
| 10 | Signaling of sphingosine-l-phosphate via the S1P/EDG-family of G-protein-coupled receptors 显示文摘 | Klu KMJ Hla T | 2002 | Biochim Biophys Acta2002，1582，13： | 1 |
| 11 | Human cyclooxygenase -2显示文摘 | Hla T Neilson K | 1992 | CDNA proc Natl Acad sci USA1992，89，： | 1 |
| 12 | Sleep apnea and hyper- tension, A Population-based study 显示文摘 | Hla KM Young TB Bidwell T | 1994 | Ann Intern Med1994，120，5： | 1 |
| 13 | Distribution of human papilloma-virus genotypes among cervical intraepithelial neoplasia and inva-sive cancers in Macao显示文摘 | Hlaing T Yip YC Nqai KL | 2010 | Med Virol2010，82，9： | 1 |
| 14 | Cyclooxygenase isozymes: the biology of prostaglandin synthesis and inhibi- tion 显示文摘 | SIMMONS D L BOtTING R M HLA T | 2004 | Pharmacological Reviews2004，56，3： | 1 |
| 15 | Molecular assessment of artemisinin-resistanee markers, polymorphisms in the K13 propeller and a multidrng-resistance gene, in eastern and western border areas of Myanmar显示文摘 | Nyunt MH Hlaing T Oo HW et d | 2014 | Clin Infect Dis2014，60，8： | 1 |
| 16 | Cyclooxygenase-1 and -2 isoenzymes显示文摘 | BISHOP-BAILEY D LIU C H | 1999 | Int J Biochem and Cell Bio1999，31，5： | 1 |
| 17 | Cyclcoxygenase isozymes: The biology of prostaglandin synthesis and inhibition显示文摘 | Simmons DL Botting RM Hla T | 2004 | Pharmacol Rev2004，56，： | 1 |
| 18 | Cyclooxygenase-2 modulates cellular growth and promotes tumorigenesis显示文摘 | Trifan OC Hla T | 2003 | Cell Mol Med2003，17，3： | 1 |
| 19 | Down-regulation of cytokine-induced cyclo-oxygenase-2transcript isoforms by dexamethasone:evidence for post-transcriptional regulation显示文摘 | Ristimki A Narko K Hla T | 1996 | Biochem J1996，318，1： | 1 |
| 20 | In vivo cyclooxygenase expression in synovial tissues of patients with rheumatoid arthritis and osteoarihritis and rats with adjuvant and streptococcal cell wall arthritis显示文摘 | Sano H Hla T Maier J A M | | 0，，： | 1 |
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