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| 1 | 麻风病全基因组关联分析显示文摘背景:由于麻风分枝杆菌宿主的局限性和难以在体外培养,限制了对麻风病的研究及其生物学方面的了解。宿主的遗传因素不仅影响对麻风菌的易感性,也影响麻风病的病程。方法:采用Illumina Human 610-Quad BeadChips对706个麻风病例及1225名正常对照人群进行全基因组扫描,扫描的结果采用PLINK软件进行统计学分析。根据分析结果对可能阳性的93个SNPs位点在3254个麻风病例及5955名正常对照中验证,以确定麻风病的易感基因。同时我们在麻风病的不同临床型别中进行了异质性检验,以期发现与型别相关的易感基因。结果:(1)研究发现位于6个区域的15个SNPs达到了全基因关联研究水平(P<1.0×10^(-8)),定位了6个麻风病的易感基因:HLA-DR,RIPK2,TNFSF15,CCDC122,C13ORF31和NOD2。另外LRRK2基因对应SNP的P值为5.10×10,提示该基因可能为麻风病的易感基因。(2)研究发现5个SNPs在多菌型麻风病中的遗传效力强于少菌型。结论:位于调节固有免疫NOD2介导的信号通路中基因的变异与麻风病的易感性相关。 | 张福仁 黄薇 陈树民 孙良丹 刘红 李毅 崔勇 颜潇潇 杨海涛 杨荣德 初同胜 张弛 张林 韩建文 于功奇 权晟 于永翔 张铮 史本青 张连华 程晖 王昌媛 林燕 郑厚峰 付希安 左先波 王强 龙恒 孙一萍 程义林 田洪青 周伏圣 刘华绪 陆闻生 何素敏 杜文莉 沈珉 金祺祎 王颖 Hui-Q iLow Tantoso Erwin Ninghan Yang 李金勇 赵欣 娇曰林 毛立国 殷刚 姜珍霞 王晓东 于京平 胡宗厚 巩翠华 柳玉强 刘瑞玉 王德民 魏东 刘金献 曹巍鲲 曹恒仲 李永平 阎维国 魏世玉 王奎军 Martin L Hibberd 杨森 张学军 刘建军 | 2010 | 中国麻风皮肤病杂志2010，，1： | 4 |
| 2 | Interaction between castanospermine an immunosuppressant and cyclosporin A in rat cardiac transplantation显示文摘AIM: To investigate the interaction between castanospermine and cyclosporin A(Cs A) and to provide an explanation for it.METHODS: The alkaloid castanospermine was prepared from the seeds of Castanospermum austral consistently achieving purity. Rat heterotopic cardiac transplantation and mixed lymphocyte reactivity were done using genetically inbred strains of PVG(donor) and DA(recipient). For the mixed lymphocyte reaction stimulator cells were irradiated with 3000 rads using a linear accelerator. Cyclosporin A was administered by gavage and venous blood collected 2 h later(C_2). The blood levels of Cs A(Neoral) were measured by immunoassay which consisted of a homogeneous enzyme assay(EMIT) on Cobas Mira. Statistical analyses of interactions were done by an acceleratedfailure time model with Weibull distribution for allograft survival and logistic regression for the mixed lymphocyte reactivity.RESULTS: Castanospermine prolonged transplant survival times as a function of dose even at relatively low doses. Cyclosporin A also prolonged transplant survival times as a function of dose particularly at doses above 2 mg/kg. There were synergistic interactions between castanospermine and Cs A in the prolongation of cardiac allograft survival for dose ranges of Cs A by castanospermine of(0 to 2) mg/kg by(0 to 200) mg/kg(HR = 0.986; 95%CI: 0.981-0.992; P < 0.001) and(0 to 3) mg/kg by(0 to 100) mg/kg(HR = 0.986; 95%CI: 0.981-0.992; P < 0.001) respectively. The addition of castanospermine did not significantly increase the levels of cyclosporin A on day 3 or day 6 for all doses of Cs A. On the contrary, cessation of castanospermine in the presence of Cs A at 2 mg/kg significantly increased the Cs A level(P = 0.002). Castanospermine inhibited mixed lymphocyte reactivity in a dose dependent manner but without synergistic interaction. CONCLUSION: There is synergistic interaction between castanospermine and Cs A in rat cardiac transplantation. Neither the mixed lymphocyte reaction nor the metabolism of Cs A provides an explanation. | Adrian D Hibberd David A Clark Paul R Trevillian Patrick Mcelduff | 2016 | World Journal of Transplantation2016，6，1： | 2 |
| 3 | Probiotics for Prevention of Antibiotic-associated Diarrhea显示文摘 | Shira Idit Doron Patricia L. Hibberd Sherwood L. Gorbach | 2008 | Journal of Clinical Gastroenterology2008，，： | 2 |
| 4 | Ultrasonic characterisation of colloidal dispersions: detection of flocculation and adsorbed layers 显示文摘 | David J Hibberd | 1999 | Colloids and Surfaces B : Biointerfaces1999，12，： | 1 |
| 5 | An assessment of LIS curricula and the field of practice in the commercial sector显示文摘 | Liz Blankson-Hemans Betty Jo Hibberd | 2004 | New Library World2004，，105： | 1 |
| 6 | Can we use influen-cing factors to predict aspiration pneumonia in the UnitedKingdom显示文摘 | Hibberd J Fraser J Chapman C | 2013 | Multidiscip Respir Med2013，8，1： | 1 |
| 7 | Probioties for prevention of an- tibiotic-associated diarrhea 显示文摘 | Doron SI Hibberd PL Gorbaeh SL | 2008 | J Clin Gastroenterol2008，42，2： | 1 |
| 8 | Upper- airway obstruction and perioperative management of the airway in patients managed with posterior operations on the cervical spine for rheumatoid arthritis 显示文摘 | Wattenmaker I Concepcion M Hibberd P | 1994 | J Bone Joint Surg Am1994，76，36： | 1 |
| 9 | Glucocorticoids and the ageing hippocampus显示文摘 | Hibberd C Yau JL Seckl JR | 2000 | J Anat2000，，1974： | 1 |
| 10 | Localization of photosynthetic metabolism in the parasitic angiosperm Cuscuta reflexa显示文摘 | HIBBERD J M BUNGARD R A PRESS M C | 1998 | Planta1998，205，： | 1 |
| 11 | Characteristics of C4 photosynthesis in stems and petioles of C3 flowering plants 显示文摘 | Hibberd J M Quick W P | 2002 | Nature2002，415，： | 1 |
| 12 | Polumorphism in the 5'end of the aldose reductase gene is strongly associated with the development of diabetic nephropathy in type I diabetes显示文摘 | Heesom AE Hibberd ML Millward A | 1997 | Diabetes1997，46，2： | 1 |
| 13 | VEGF,flk-1,and flk- 1 expression in a rat myocardial infarction model of angiogenesis显示文摘 | Li J Brown LF Hibberd MG | 1996 | Am J Physiol1996，270，： | 1 |
| 14 | Probiotics for prevention of antibiotic - associated diarrhea 显示文摘 | Doron SI Hibberd PL Gorbach SL | 2008 | Clin Gastroenterol2008，42，2： | 1 |
| 15 | The H+-sucrose cotransporter NtSUT1 is essential for sugar export from tobacco leaves 显示文摘 | Burkle L Hibberd J M Quick W P | 1998 | Plant Physiol1998，118，： | 1 |
| 16 | A numerical model for oil film flow in an aeroengine bearing chamber and comparison to ex- perimental data 显示文摘 | Farrall M Simmons K Hibberd S | 2006 | Transactions of the ASME-Journal of Engineering for Gas Turbines and Power2006，128，1： | 1 |
| 17 | Characteristics of C4photosynthesis in stems and petioles of C3flowering plants显示文摘 | Hibberd J M Quick W P | 2002 | Nature2002，415，： | 1 |
| 18 | Serial Analysis of the Gut and Respiratory Microbiome in Cystic Fibrosis in Infancy: Interaction between Intestinal and Respiratory Tracts and Impact of Nutritional Exposures显示文摘 | J. C. Madan D. C. Koestler B. A. Stanton L. Davidson L. A. Moulton M. L. Housman J. H. Moore M. F. Guill H. G. Morrison M. L. Sogin T. H. Hampton M. R. Karagas P. E. Palumbo J. A. Foster P. L. Hibberd G. A. O’Toole | 2012 | mBio2012，，： | 1 |
| 19 | Probiotics for prevention of antibioticassociated diarrhea显示文摘 | Doron SI Hibberd PL Gorbach SL | 2008 | J Clin Gastroenterol2008，42，2： | 1 |
| 20 | Chloramphenicol versus ampicillin plus gentamicin for community acquired very severe pneumonia among children aged 2- 59 months in low resource settings: multicentre randomised controlled trial (SPEAR study)显示文摘 | Asghar R Banajeh S Egas J Hibberd P lqbal I Katep-Bwalya | 2008 | BMJ2008，336，7635： | 1 |
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