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| 1 | Antidiabetic and in vitro antioxidant potential of Hybanthus enneaspermus(Linn) F.Muell in streptozotocin—induced diabetic rats显示文摘Objective:To evaluate antidiabetic and antioxidant potential of Hybanthus enneaspermus in different models.Methods:The oral glucose tolerance test(OGTT) and normoglycemic effect of alcoholic extract of Hybanthus enneaspermus(AHE) were evaluated at a dose of 125,250 and 500mg/kg p.o.while hypoglycemic activity and effect on body weight were tested at 250 and 500 mg/kg p.o.per day for 21 days in Streptozotocin(STZ) induced diabetic rats.Further,glucose uptake by hemidiaphram was also evaluated.The total polyphenolic and flavonoid were determined and their correlation with various antioxidant assays was also determined.Results:The results showed high level of phenolic content in AHE.AHE also exhibited higher total antioxidant capacity,good reducing power and a significant scavenger of reactive oxygen species like DPPH radical,nitric oxide,hydrogen peroxide and deoxyribose.Furthermore there was a significant increase in the body weight and decrease in the blood glucose level on treatment with the AHE.AHE increased glucose uptake on isolated rat hemi-diaphragm compared to control group.Conclusions:AHE reduce blood glucose level in STZ-induced diabetic model.It does not show significant effect in normoglycemic study but showes significant effect in OGT.AHE has significant antioxidant activity,which may be attributed to high phenolic content. | Patel DK Kumar R Prasad SK Sairam K Hemalatha S | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，4： | 22 |
| 2 | Diabetes mellitus:An overview on its pharmacological aspects and reported medicinal plants having antidiabetic activity显示文摘Diabetes mellitus is not a single disease but is a group of metabolic disorders affecting a huge numlier of population in the world.It is mainly characterized by chronic hyperglycemia,resulting from defects in insulin secretion or insulin action.It is predicated that the number of diabetes person in the world could reach upto 366 million by the year 2030.Even though the cases of diabetes are increasing day by day,except insulin and oral hypoglycemic drugs no other way of treatment has been successfully developed so far.Thus,the objective of the present review is to provide an insight over the pathophysiological and etiological aspects of diabetes mellitus along with the remedies available for this metabolic disorder.The review also contains brief idea about diabetes mellitus and the experimental screening model with their relevant mechanism and significance mainly used nowadays.Alloxan and streptozotocin are mainly used for evaluating the antidiabetic activity of a particular drug.This review contain list of medicinal plants which have been tested for their antidiabetic activity in the alloxan induced diabetic rat model.From the available data in the literature,it was found that plant having antidiabetic activity is mainly due to the presence of the secondary metabolite.Thus,the information provided in this review will help the researchers for the development of an alternative methods rather than insidin and oral hypoglycemic agents for the treatment of diabetes niellitus,which will minimize the complication associated with the diabetes and related disorder. | Patel DK Kumar R Laloo D Hemalatha S | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，5： | 17 |
| 3 | An overview on antidiabetic medicinal plants having insulin mimetic property显示文摘Diabetes mellitus is one of the common metabolic disorders acquiring around 2.8%of the world's population and is anticipated to cross 5.4%by the year 2025.Since long back herbal medicines have been the highly esteemed source of medicine therefore,they have become a growing part of modern,high-tech medicine.In view of the above aspects the present review provides profiles of plants(65 species) with hypoglycaemic properties,available through literature source from various database with proper categorization according to the parts used,mode of reduction in blood glucose(insulinomimetic or insulin secretagugues activity) and active phyloconsliluents having insulin mimetics activity.From the review it was suggested that,plant showing hypoglycemic potential mainly belongs to the family Leguminoseae,Lamiaceae,Liliaceae,Cucurbitaceae, Asteraceae,Moraceae,Rosaceae and Araliaceae.The most active plants are Allium sativum. Gymnema sylvestre,Citrullus colocynthis,Trigonella foenum greacum,Momordica charantia and Ficuts bengalensis.The review describes some new bioactive drugs and isolated compounds from plants such as roseoside,epigallocatechin gallate,beta-pyrazol-1-ylalanine,cinchonain Ib,leucocyandin 3-O-beta-d-galactosyl cellobioside,leucopelargonidin-3- O-alpha-L rhamuoside,glycyrrhetinic acid,dehydrotrametenolic acid,strictinin,isostrictinin,pedunculagin, epicatechin and christinin-A showing significant insulinomimetic and antidiabetic activity with more efficacy than conventional hypoglycaemic agents.Thus,from the review majorly,the antidiabetic activity of medicinal plants is attributed to the presence of polyphenols,flavonoida, terpenoids,coumarins and other constituents which show reduction in blood glucose levels.The review also discusses the management aspect of diabetes mellitus using these plants and their active principles. | Patel DK Prasad SK Kumar R Hemalatha S | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，4： | 15 |
| 4 | Pedalium murex Linn(Pedaliaceae) fruits:a comparative antioxidant activity of its different fractions显示文摘Objective:To examine the antioxidant activity and total phenolic content of different solvent fractions of Pedulium murex(P.murex)Linn fruits(Family:Pedaliaceae)as well as the correlation between the total antioxidant capacity and total phenolic content.Methods:In the present study,the antioxidant activities of P.murex were evaluated using six in-vitro assays,namely total antioxidant assay,DPPH assay,reducing power,nitric oxide scavenging,hydrogen peroxide scavenging and deoxyribose scavenging assays,and total phenol contents were also investigated.Results:The ethyl acetate(EA)fraction was found to have high levels of phenolic content(298.72±2.09 mg GAE/g).The EA fraction exhibit higher total antioxidant capacity,higher percentage of DPPH radical scavenging activity(135.11±2.95μg/mL),nitric oxide(200.57±4.5lμg/mL),hydrogen peroxide(2I7.91±6.12μg/mL),deoxyribose(250.01±4.68μg/mL)and higher reducing power.Correlation coefficient(r^2=0.914)was found to be significant between total phenolic content and total antioxidant activity.Conclusions:In general,the results indicate that the EA fractions are rich in phenolic antioxidants with potent free radical scavenging activity implying their importance to human health. | DK Patel R Kumar SK Prasad S Hemalatha | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，5： | 12 |
| 5 | Antidiabetic activity of alcoholic leaves extract of Alangium lamarckii Thwaites on streptozotocin-nicotinamide induced type 2 diabetic rats显示文摘Objective:To investigate antidiabetic potential of alcoholic leaves extract of Alangium lamarekii (A.lamarckii) on streptozotocin-nicotinamide induced type 2 diabetic rats.Methods:Oral glucose tolerance test was done by inducing hyperglycemic state via administration of glucose in water(2 g/kg).Single dose of alcoholic leaves extract of.4.lamarckii(250 and 500 mg/kg,p.o.) were administered to normoglycemic,hyperglycemic rats.Type 2 diabetes was induced by single intraperitoneal injection of nicotinamide(110 mg/kg) followed by streptozotocin(65 mg/kg).The study also included estimations of blood plasma glucose,lipid profile,liver glycogen,body weight and antioxidant status in normal and diabetic rats.Results:Admistration of alcoholic extract of A.lamarekii at two dosage 250 and 500 rag/kg,p.o.did not showed any significant change in blood glucose level of normoglycemic rats(P>0.05).whereas,oral glucose tolerance test depicted reduction in blood glucose level(P<0.05).The streptozotocin-nicotinamide induced diabetic rats, significantly decreased the blood plasma glucose level(P<0.001) comparable to glibenclamide (10 mg/kg),restored the lipid profile and showed improvement in liver glycogen,body weight and antioxidant status in diabetic rats.Conclusions:Present finding demonstrated the significant antidiabetic activity of alcoholic leaves extract of.4.lamarekii. | Rajesh Kumar Dinesh Kumar Pate Satyendra Kuldip Prasad Kirshnamurthy Sairam Siva Hemalatha | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，11： | 8 |
| 6 | Evaluation of phytochemical and antioxidant activities of the different fractions of Hybanthus enneaspermus (Linn.) F.Muell. (Violaceae).显示文摘Objective:To investigate the naturally occurring antioxidant for the first time from the different solvent fractions of Hybanthus enneaspermus(H.enneaspermus) Linn F.Muell.family(Violaceae). Methods:Different fractions of H.enneaspermus were tested for total phenolic content,and in vitro antioxidant activity was measured by total antioxidant assay,DPPH assay,reducing power, nitric oxide(NO),hydrogen peroxide(H2O2) scavenging assays.Results:The ethyl acetate(EA) fraction was found to have high levels of phenolic content[(212.15±0.79) mg GAE/g].The EA fraction exhibited higher total antioxidant capacity,higher percentage of DPPH radical scavenging activity[(127.07±2.29) Fg/mL],nitric oxide[(245.16±1.44)μg/mLJ,hydrogen peroxide[(227.38±7.18)μg/mL],deoxyribose[(270.61±8.72)μg/mL]and higher reducing power.There was a significant correlation between total phenolic content and total antioxidant activity(r =0.972). Conclusions:These results reveal that EA fraction of H.enneaspermus has strong antioxidant potential compared with other fractions.Our further study has been extended to the isolation of the possible compound that is responsible for having antioxidant property. | Dinesh Kumar Patel Rajesh Kumar Damiki Laloo Siva Hemalatha | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，5： | 7 |
| 7 | Anti-anaphylactic and anti-inflammatory activities of a bioactive alkaloid from the root bark of Plumeria acutifolia Poir显示文摘Objective:To investigate the anti-anaphylactic,anti-inflammatory and membrane stabilizing properties of plumerianine(compound 1)isolated from the root bark of Plumeria acuifolia Poir.Methods:The anti-anaphylactic activity of compound 1(10,25 and 50 mg/kg)was studied by using models such as passive cutaneous anaphylaxis,passive paw anaphylaxis and its antiinflammatory activity against carrageenin induced paw edema and cotton pellet granuloma in albino rats was also investigated using ketotifen and indomethacin as reference drugs.Results:A dose-dependent beneficial effect was observed on leakage of evans blue dye in skin challenged with antigen and on paw anaphylaxis induced by antiserum.The compound 1 also exhibited significant(P<0.01)inhibition of rat paw edema and granuloma tissue formation,including significant protection of RBC against the haemolytic effect of hypotonic solution,an indication of membrane-stabilizing activity.Conclusions:Anti-anaphylactic activity of compound 1 may be possibly due to inhibition of the release of various inflammatory mediators.Anti-inflammatory activity of compound may be related to the inhibition of the early phase and late phase of inflammatory events. | A Vijayalakshmi V Ravichandiran Malarkodi Velraj S Hemalatha G Sudharani S Jayakumari | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，5： | 6 |
| 8 | Preparation and Characterization of Hydroxyapatite-Coated Selenium Nanoparticles and their Interaction with Osteosarcoma(SaOS-2) Cells显示文摘Nanotechnology has taken a firm step to revolutionize the field of orthopedic implants. Current research on bone implants focuses to develop implants with multifaceted functions viz., osteoinduction, chemoprevention, antimicrobial action etc., especially for cancerous bone resection. The objective of the present study was to synthesize a novel composite for bone implants, possessing the above properties. Selenium was selected owing to its chemopreventive and chemotherapeutic properties. Hydroxyapatite was selected owing to its bioactivity and similarity in composition to bone mineral properties. Selenium nanoparticles were prepared by chemical reduction method and coated with hydroxyapatite.Hydroxyapatite-coated selenium nanoparticle(HASnp) was characterized physico-chemically using fourier transform infrared spectroscopy, X-ray diffractometry, scanning electron microscope, and energy-dispersive X-ray spectroscopy.HASnp was analysed in vitro using SaOS-2 cell line. Enhanced cell proliferation and alkaline phosphatase activity were observed in HASnp-treated cells. The results indicate that HASnp is highly suitable for the use in orthopedic applications. | Thiagarajan Hemalatha Gunasekaran Krithiga Baskar Santhosh Kumar Thotapalli P. Sastry | 2014 | Acta Metallurgica Sinica(English Letters)2014，27，6： | 4 |
| 9 | Inhibitory effect of two Indian medicinal plants on aldose reductase of rat lens in vitro显示文摘Objective:To assesse the inhibitor) effect of alcoholic extract of two Indian medicinal plants namely Ceasalpinia digyna Rottler and.Alangium lamarckii Thwaits on aldose reductase(AR) of rat lens.Methods:Rats lens were enucleated through posterior approach and their homogenate was prepared and centrifuged to obtain a clear supernatant for the determination of AR activity and protein content.Results:The alcoholic extract of Ceasalpirda digyna and Alangium lamarckii had a potent inhibitory effect on the lens AR enzyme.The IC50 values of alcoholic extract of the selected plants were calculated and were(46.29±11.17) and(106.00±5.11)μg/mL,respectively. Quercetin was used as a positive control and its IC50 value was(2.95±1.53)μg/mL.Conclusions:Thus,it is concluded that alcoholic extracts of the selected plant exhibit significant inhibitory effects on AR in the rat lens in vitro. | Rajesh Kumar Dinesh Kumar Patel Damiki Laloo Krishnamurthy Sairam Siva Hemalatha | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，9： | 4 |
| 10 | Evaluation of in vitro aldose reductase inhibitory potential of different fraction of Hybanthus enneaspermus Linn F.Muell显示文摘Objective:To evaluate the aldose reductase inhibitory(ARI)activity of different fractions of Hybanthus enneaspermus for potential use in diabetic cataract.Methods:Total phenol and flavonoid content of different fractions was determined.ARI activity of different fractions in rat lens was investigated in vitro.Results:The results showed significant level of phenolic and flavonoid content in ethyl acetate fraction[total phenol(212.15±0.79 mg/g),total flavonoid(39.11±2.27mg/g)]and aqueous fraction[total phenol(140.62±0.57mg/g),total flavonoid(26.07±1.49 mg/g)]as compared with the chloroform fraction[total phenol(68.56±0.51mg/g),total flavonoid(13.41±0.82mg/g)]and petrolium ether fraction[total phenol(36.68±0.43mg/g),total flavonoid(11.55±1.06mg/g)].There was a significant difference in the ARI activity of each fraction,and it was found to be the highest in ethyl acetate fraction[IC_(50)(49.26±1.76μg/mL)]followed by aqueous extract[IC_(50)(70.83±2.82μg/mL)]and it was least in the petroleum ether fraction[IC_(50)(118.89±0.71μg/mL)].Chloroform fraction showed moderate activity[IC_(50)(98.52±1.80μg/mL)].Conclusions:Different fractions showed significanct amount of ARI activity,where in ethyl acetate fraction it was found to be maximum which may be due to its high phenolic and flavonoid content.The extract after further evaluation may be used in the treatment of diabetic cataract. | Patel DK Kumar R Kumar M Sairarn K Hemalatha S | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，2： | 4 |
| 11 | Pedalium murex Linn.:An overview of its phytopharmacological aspects显示文摘Pedalium murex Linn(family:Pedaliaceae)(P.murex) commonly known as Large Caltrops and Gokhru(India) is a shrub found in the Southern part.Deccan region of India and in some parts of Ceylon.Different parts of the plant are used to treat various ailments like,cough,cold and as an antiseptic.Interestingly.P.murex is reported traditionally to have an excellent cure in patients with reproductive disorders which are mainly impotency in men.nocturnal emissions,gonorrhoea as well as leucorrhoea in women.The plant has also benifiled in complications like urinary track disorder as well as gastro intestinal tract disorders.Phytochemically the plant is popular for the presence of a considerable amount of diosgenin and vanillin which are regarded as an important source and useful starting materials for synthesizing steroidal contraceptive drugs and isatin alkaloids.Other phytochemicals reported in the plant includes quercetin.ursolic acid,caffeic acid,amino acids(glycine,histidine,tyrosine,threonine,aspartie acid and glutamic acid) and various classes of fatty acids(triacontanoic acid,nonacosane.tritriacontane.tetratriacontanyl and heptatriacontan-4-one).Pharmacologically,the plant have been investigated for antiulcerogenic. nephroprotective.hypolipidemic,aphrodisiac,antioxidant,antimicrobial and insecticidal activities.From all these reports it can be concluded that the plant were found to have a better profile with potential natural source for the treatment of various range of either acute or chronic disease.The overall database of our review article was collected from the scientific sources in regards with all the information ol the research article for P.murex published so far. | Dinesh Kumar Patel Damiki Laloo Rajesh Kumar Siva Hemalatha | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，9： | 3 |
| 12 | ZSM-5沸石结晶度对乙苯叔丁基化对位选择性的影响(英文)显示文摘Highly crystalline ZSM-5 zeolites are important for para-selective alkylation of alkyl aromatics, because they carry few external acid sites for isomerization of p-dialkyl products. Such zeolites (Si/Al = 25, 50, and 75) were synthesized in a fluoride medium between pH 4 and 6. Their crystallinities, crystal sizes, and surface areas were higher than those of a commercial ZSM-5 zeolite. Their para selectivities in alkylation were tested for vapor-phase tert-butylation of ethylbenzene between 200 and 400 °C. As expected, all the catalysts showed more than 90% para selectivity. At 300 °C, ethylbenzene conversion decreased in the order ZSM-5(25, commercial) > ZSM-5(25) > ZSM-5(50) > ZSM-5(75). The catalysts had weak, medium, and strong acid sites, but all the acid sites of ZSM-5(75) were weaker than those of ZSM-5(25) and ZSM-5(50). The high activity of commercial ZSM-5 was caused by its strong acid sites being stronger than those of the synthesized zeolites. Although the activity of the commercial catalyst was higher than those of the present catalysts, the selectivity for 4-t-butylethylbenzene (4-t-BEB) was low. The optimum feed ratio (ethylbenzene:t-butyl alcohol) was 2:1 and the feed rate was 1.65 h?1 for high ethylbenzene conversion and 4-t-BEB selectivity. Time-on-stream studies showed slow catalyst deactivation. Highly crystalline ZSM-5 zeolites are therefore better than a commercial zeolite for para-selective alkylation of alkyl aromatics. They do not require much post-modification for high para selectivity. A fluoride medium is therefore better than an alkaline medium for obtaining highly crystalline para-selective ZSM-5 zeolites. | PUSHPARAJ Hemalatha MANI Ganesh MUTHIAHPILLAI Palanichamy VELAYUTHAM Murugesan PARK Yong-Ki CHOI Won Choon JANG Hyun Tae | 2013 | 催化学报2013，34，2： | 2 |
| 13 | Synthesis and screening of some novel substituted indoles contained 1,3,4-oxadiazole and 1,2,4-triazole moiety显示文摘<正>A series of novel 3-[5-(1H-indol-3-yl-methyl)-2-oxo-[1,3,4]oxadiazol-3-yl]propionitrile(5),3-[4- amino-3-(1H-indol-3-yl-methyl)-5-oxo-4,5-dihydro-[1,2.4]triazol-1-yljpropionitrile(6),3-[5-(1H- indol-3-yl-methyl)-2-thioxo-[1,3,4]oxadiazol-3-yl]propionitrile(7) and 3-[4-amino-3-(1H-indol-3-yl-methyl) -5-thioxo-4,5-dihydro-[1,2,4]triazol-l -yljpropionitrile(8) were synthesized in good yields from the intermediate(1H-indol-3-yl)-acetic acid N’-(2-cyanoethyl)hydrazide(4).The chemical structures of the newly synthesized compounds were elucidated by their IR,~1H NMR and MS.Further,all the compounds were screened for their antimicrobial activity against Gram-positive,Gram-negative bacteria and also tested their ability toward anti-inflammatory activity. | Hemalatha Gadegoni Sarangapani Manda | 2013 | Chinese Chemical Letters2013，24，2： | 2 |
| 14 | Natural medicines from plant source used for therapy of diabetes mellitus: An overview of its pharmacological aspects显示文摘 | DK Patel R Kumar D Laloo S Hemalatha | 2012 | Asian Pacific Journal of Tropical Disease2012，，3： | 2 |
| 15 | Cataract: A major secondary complication of diabetes, its epidemiology and an overview on major medicinal plants screened for anticataract activity显示文摘 | DK Patel SK Prasad R Kumar S Hemalatha | 2011 | Asian Pacific Journal of Tropical Disease2011，，4： | 2 |
| 16 | Detection of AmpC beta lactamases production in Escherichia coli & Klebsiella by an inhibitor based method 显示文摘 | Hemalatha V Padma M Sekar U | 2007 | Indian J Med Res2007，126，3： | 1 |
| 17 | Microwave Assisted Extraction-An Innovative and Promising Extraction Tool for Medicinal Plant Research 显示文摘 | Vivekananda Mandal Yogesh Mohan S Hemalatha | 2007 | Pharmaco gnosy Reviews2007，1，1： | 1 |
| 18 | A Survey on Software Protection Techniques against Various Attacks显示文摘 | Sasirekha N Hemalatha M | 2012 | Global Journal of Computer Science and Technology2012，12，1： | 1 |
| 19 | Microwave assisted extration-an innovative and promising extraction tool for medicinal plant research显示文摘 | Mandal V Mohan Y Hemalatha S | 2007 | Pharmacogn Rev2007，1，1： | 1 |
| 20 | IKKε modulates RSV-induced NF-κB-dependent gene transcription显示文摘 | Xiaoyong Bao Hemalatha Indukuri Tianshuang Liu Sui-Ling Liao Bing Tian Allan R. Brasier Roberto P. Garofalo Antonella Casola | 2010 | Virology2010，，2： | 1 |
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