|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Clinical correlates of common corneal neovascular diseases: a literature review显示文摘A large subset of corneal pathologies involves the formation of new vessels(neovascularization), leading to compromised visual acuity. This article aims to review the clinical causes and presentations of corneal neovascularization(CNV) by examining the mechanisms behind common CNV-related corneal pathologies, with a particular focus on herpes simplex stromal keratitis,contact lenses-induced keratitis and CNV secondary to keratoplasty. Moreover, we reviewed CNV in the context of different types of corneal transplantation and keratoprosthesis, and summarized the most relevant treatment available so far. | Nizar Saleh Abdelfattah Mohamed Amgad Amira A Zayed Hamdy Salem Ahmed E Elkhanany Heba Hussein Nawal Abd El-Baky | 2015 | International Journal of Ophthalmology(English edition)2015，8，1： | 10 |
| 2 | Development of an Arabic version of the National Eye Institute Visual Function Questionnaire as a tool to study eye diseases patients in Egypt显示文摘AIM:To develop and test an Arabic version of the National Eye Institute Visual Function Questionnaire-25(NEI-VFQ-25).METHODS:NEI-VFQ-25 was translated into Arabic according to WHO translation guidelines. We enrolled adult consenting patients with bilateral chronic eye diseases who presented to 14 hospitals across Egypt from October to December 2012, and documented their clinical findings. Psychometric properties were then tested using STATA.RESULTS:We recruited 379 patients, whose mean age was(54.5±15)y. Of 46.2% were males, 227 had cataract,31 had glaucoma, 23 had retinal detachment, 37 had diabetic retinopathy, and 61 had miscellaneous visual defects. Non-response rate and the floor and ceiling numbers of the Arabic version(ARB-VFQ-25) were calculated. Internal consistency was high in all subscales(except general health), with Cronbach-α ranging from0.702-0.911. Test-retest reliability was high(intraclass correlation coefficient 0.79).CONCLUSION:RB-VFQ-25 isareliableandvalidtool for assessing visual functions of Arabic speaking patients. However, some questions had high non-response rates and should be substituted by available alternatives. Our results support the importance of including self-reported visual functions as part of routine ophthalmologic examination. | Nizar Saleh Abdelfattah Mohamed Amgad Ahmed A Salama Marina E Israel Ghada A Elhawary Ahmed E Radwan Mohamed M Elgayar Tamer M EL Nakhal Islam T Elkhateb Heba A Hashem Doha K Embaby Amira A Elabd Reem K Elwy Magdi S Yacoub Hamdy Salem Mohamed Abdel-Baqy Ahmad Kassem | 2014 | International Journal of Ophthalmology(English edition)2014，7，5： | 8 |
| 3 | Towards hepatitis C virus elimination:Egyptian experience,achievements and limitations显示文摘Worldwide, more than one million people die each year from hepatitis C virus(HCV) related diseases, and over 300 million people are chronically infected with hepatitis B or C. Egypt used to be on the top of the countries with heavy HCV burden. Some countries are making advances in elimination of HCV, yet multiple factors preventing progress; remain for the majority. These factors include lack of global funding sources for treatment, late diagnosis, poor data, and inadequate screening. Treatment of HCV in Egypt has become one of the top national priorities since 2007. Egypt started a national treatment program intending to provide cure for Egyptian HCV-infected patients. Mass HCV treatment program had started using Pegylated interferon and ribavirin between 2007 and 2014. Yet, with the development of highly-effective direct acting antivirals(DAAs) for HCV, elimination of viral hepatitis has become a real possibility. The Egyptian National Committee for the Control of Viral Hepatitis did its best to provide Egyptian HCV patients with DAAs. Egypt adopted a strategy that represents a model of care that could help other countries with high HCV prevalence rate in their battle against HCV. This review covers the effects of HCV management in Egyptian real life settings and the outcome of different treatment protocols. Also, it deals with the current and future strategies for HCV prevention and screening as well as the challenges facing HCV elimination and the prospect of future eradication of HCV. | Dalia Omran Mohamed Alboraie Rania A Zayed Mohamed-Naguib Wifi Mervat Naguib Mohamed Eltabbakh Mohamed Abdellah Ahmed Fouad Sherief Sahar Maklad Heba Hamdy Eldemellawy Omar Khalid Saad Doaa Mohamed Khamiss Mohamed El Kassas | 2018 | World Journal of Gastroenterology2018，24，38： | 2 |
| 4 | Safety and efficacy of Hansenula-derived PEGylated-interferon alpha-2a and ribavirin combination in chronic hepatitis C Egyptian children显示文摘AIM:To investigate the safety and efficacy of a Hansenula-derived PEGylated(polyethylene glycol)interferon(IFN)-alpha-2a(Reiferon Retard)plus ribavirin customized regimen in treatment-na?ve and previously treated(non-responders and relapsers)Egyptian children with chronic hepatitis C infection.METHODS:Forty-six children with chronic hepatitis C virus(HCV)infection were selected from three tertiary pediatric hepatology centers.Clinical and laboratory evaluations were undertaken.Quantitative polymerase chain reaction(PCR)for HCV-RNA was performed before starting treatment,and again at 4,12,24,48,72wk during treatment and 6 mo after treatment cessation.All patients were assigned to receive a weekly subcutaneous injection of PEG-IFN-alpha-2a plus daily oral ribavirin for 12 wk.Thirty-four patients were treatment-na?ve and 12 had a previous treatment trial.Patients were then divided according to PCR results into two groups.GroupⅠincluded patients who continued treatment on a weekly basis(7-d schedule),while groupⅡincluded patients who continued treatment on a 5-d schedule.Patients from either group who were PCR-negative at week 48,but had at least one PCRpositive test during therapy,were assigned to have an extended treatment course up to 72 wk.The occurrence of adverse effects was assessed during treatment and follow up.The study was registered at www.ClinicalTrials.gov(NCT02027493).RESULTS:Only 11 out of 46(23.9%)patients showed a sustained virological response(SVR),two patients were responders at the end of treatment;however,they were lost to follow up at 6 mo post treatment.Breakthrough was seen in 18(39.1%)patients,one patient(2.17%)showed relapse and 14(30.4%)were non-responders.Male gender,short duration of infection,low viral load,mild activity,and mild fibrosis were the factors related to a better response.On the other hand,patients with high viral load and absence of fibrosis failed to respond to treatment.Before treatment,liver transaminases were elevated.After commencing treatment,they were normalized in all patients at week 4 and were maintained normal in responders till the end of treatment,while they increased again significantly in non-responders(P=0.007 and 0.003 at week 24 and 72 respectively).The 5-d schedule did not affect the response rate(1/17 had SVR).Treatment duration(whether 48 wk or extended course to 72 wk)gave similar response rates(9/36 vs 2/8 respectively;P=0.49).Type of previous treatment(short acting IFN vs PEG-IFN)did not affect the response to retreatment.On the other hand,SVR was significantly higher in previous relapsers than in previous non-responders(P=0.039).Only mild reversible adverse effects were observed and children tolerated the treatment well.CONCLUSION:Reiferon Retard plus ribavirin combined therapy was safe.Our customized regimen did not influence SVR rates.Further trials on larger numbers of patients are warranted. | Suzan El Naghi Tawhida Y Abdel-Ghaffar Hanaa El-Karaksy Elham F Abdel-Aty Mona S El-Raziky Aleef A Allam Heba Helmy Hanaa A El-Araby Behairy E Behairy Mohamed A El-Guindi Hatem El-Sebaie Aisha Y Abdel-Ghaffar Nermin A Ehsan Ahmed M El-Hennawy Mostafa M Sira | 2014 | World Journal of Gastroenterology2014，20，16： | 2 |
| 5 | Flavonoid constituents of Ephedra alata显示文摘 | Mahmoud A M N Hassan I E Heba H B | 1984 | Phytochemistry1984，23，12： | 1 |
| 6 | Flavonoids from Ephedra aphylla显示文摘 | Sahar A M H Heba H B Mahmoud A M N | 1997 | Phytochemistry1997，45，7： | 1 |
| 7 | Inter-individual variability in response to clopidogrel in patients with coronary artery disease显示文摘 | Dziewierz A Dudek D Heba G | 2005 | Kardiol Pol2005，62，： | 1 |
| 8 | Mode of action of gingerols and shogaols on 5HT3 receptors : binding studies, cation uptake by the receptor channel and contraction of isolated guinea-pig ilum显示文摘 | HEBA A AZIZ Timo W | 2006 | Eur J Pham2006，530，1： | 1 |
| 9 | Chemical and biological investigations of the constitutivesphenolics of two Egyptian folkmedicinal plants:a novel phenolic from the galls of Tamarixaphylla显示文摘 | Barakat Heba H Nada Somaia A | 1996 | Natural Product Sciences1996，2，2： | 1 |
| 10 | Biodegradable polymeric vesicles containing magnetic nanoparticles,quantum dots and anticancer drugs for drug delivery and imaging显示文摘 | Ye F Asa B Heba A | 2014 | Biomaterials2014，35，12： | 1 |
| 11 | Inter-individual variability in response to clopidogrel in patients with coronary artery disease 显示文摘 | Ziewierz A Dudek D Heba G | 2005 | Kardiol Pol2005，62，2： | 1 |
| 12 | Inter-individual variability in response to clopidogrel in patients with coronary artery disease显示文摘 | Dziewierz A Dudek D Heba G | 2005 | Kardiol Pol2005，62，2： | 1 |
| 13 | Effect of oxi- dative stress induced by paradoxical sleep deprivation on the activities of Na+ , K +-ATPase and acetylcholinesterase in the cortex and hippocampus of rat 显示文摘 | YASSER A K NEVEEN A N HEBA S A | 2011 | Transl Res2011，157，2： | 1 |
| 14 | Inter - individual variability in response to clopidogrel in patients with coronary artery disease显示文摘 | Dziewierz A Dudek D Heba G | 2005 | Kardiol Pol2005，62，2： | 1 |
| 15 | Mesenchymal stem cells inhibit natural killer cell proliferation, cytotoxieity and cytokine production: role of indoleamine 2, 3-dioxy-genase and prostaglandin E2显示文摘 | Grazia M S Heba A Flavio B | 2009 | Abstracts2009，16，3： | 1 |
| 16 | Inter-individual variability in response to clopidogrel in patients with coronary artery disease显示文摘 | Dudek D Heba G | 2005 | Kardiol Pol2005，62，2： | 1 |
| 17 | Interindividual variability in response to clopidogel in patients with coronary artery disease 显示文摘 | Dziewierz A Dudek D Heba G | 2005 | Kardiol Pol2005，62，2： | 1 |
| 18 | Vesicular powder as carrier for doxycy-cline hydrochloride and metronidazole combination therapy 显示文摘 | Heba A Kamel Amany O | 2014 | Pharmaceutical Development and Technology2014，19，6： | 1 |
| 19 | Inter-individual variability in response to clopidogrel in patients with coronary artery disease显示文摘 | Dziewierz A Dudek D Heba G | 2005 | Kardiol Pol2005，62，11： | 1 |
| 20 | Inter-individual variability in response toelopidogrel in patients with coronary artery disease 显示文摘 | Dziewierz A Dudek D Heba G | 2005 | Kardiol Pol2005，62，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员