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| 1 | 体内腺相关病毒-常间回文重复序列丛集及其相关蛋白9介导的基因编辑可改善家族性高胆固醇血症的动脉粥样硬化显示文摘低密度脂蛋白受体(low-density lipoprotein receptor,Ldlr)基因突变是家族性高胆固醇血症的主要原因之一,可导致动脉粥样硬化,并具有很高的终生心血管病风险。常间回文重复序列丛集(clustered regularly interspaced short palindromic repeats,CRISPR)/CRISPR相关蛋白9(CRISPR-related protein 9,Cas9)系统是基因编辑纠正基因突变从而改善疾病的有效工具。该研究的目的是通过腺相关病毒(adeno-associated virus,AAV)携带的CRISPR/Cas9系统进行体内体细胞基因编辑,以确定其能否在小鼠模型中治疗由Ldlr突变体引起的家族性高胆固醇血症。 | 刘青(译) 叶鹏(审校) Zhao H Li Y He L Pu W Yu W Li Y Wu YT Xu C Wei Y Ding Q Song BL Huang H Zhou B | 2020 | 中华高血压杂志2020，28，3： | 22 |
| 2 | 血清netrin-1增加与缺血性脑卒中预后改善相关显示文摘先前的实验研究表明,血清netrin-1与缺血性脑卒中进展相关。进一步了解缺血性脑卒中患者中netrin-1的变化可能为缺血性脑卒中的预后评估提供新的思路。该研究旨在探讨血清netrin-1与缺血性脑卒中预后的关系。研究人员测定3346例中国急性缺血性脑卒中抗高血压试验(China antihypertensive trial in acute ischemic stroke,CATIS)中缺血性脑卒中患者基线血清netrin-1水平,所有患者均在脑卒中发病后3个月进行随访。主要观察指标是脑卒中发病后3个月内死亡和严重残疾(改良Rankin 量表评分≥3)。 | 刘莉 叶鹏 Guo D Zhu Z Zhong C Peng H Wang A Xu T Peng Y Xu T Chen CS Li Q Ju Z Geng D Chen J Zhang Y He J | 2019 | 中华高血压杂志2019，27，5： | 6 |
| 3 | Cyanea capillata tentacle-only extract as a potential alternative of nematocyst venom:its cardiovascular toxicity and tolerance to isolation and purification procedures显示文摘 | Xiao L He Q Guo Y | 2009 | Toxicon2009，53，1： | 1 |
| 4 | Delay-range-dependent stability for systems with time-varying delay显示文摘 | He Y Wang Q G Lin C | 2007 | Automatica2007，43，： | 1 |
| 5 | Production of tetraploid pearl oyster (Pinctada martensii Dunker) by inhibiting the first polar body in eggs from triploids 显示文摘 | He M Lin Y Shen Q | 2000 | Journal of Shellfish Research2000，19，1： | 1 |
| 6 | Analysis and design of fuzzy controller and fuzzy observer显示文摘 | Ma X J Sun Z Q He Y Y | 1998 | IEEE Trans on Fuzzy Systems1998，6，1： | 1 |
| 7 | Analysis and design of fuzzy controller and observer 显示文摘 | Ma X J Sun Z Q He Y Y | 1998 | IEEE Trans on Fuzzy Systems1998，6，1： | 1 |
| 8 | Biomacromolecules显示文摘 | Chen Y Ding D Mao Z Q He Y F Hu Y Wu W Jiang X Q | 2008 | 9(10):2609-26142008，9，10： | 1 |
| 9 | The distributions of particulate heavy metals and its indication to the transfer of sediments in the Changjiang Estuary and Hangzhou Bay, China 显示文摘 | Che Y He Q Lin W Q | 2003 | Marine Pollution Bulletin2003，46，1： | 1 |
| 10 | Mechanical properties of single crystal tungsten microwhiskers characterized by nanoindentation 显示文摘 | HUANG H WU Y Q WANG S L HE Y H ZOU J HUANG B Y LIU C T | 2009 | Materials Science and Engeering A2009，53，12： | 1 |
| 11 | Modulation of preactivation of PPAR : on memory and learning dysfunction and inflammatory response in the hippocampus in rats exposed to global cerebral ischemia/reperfusion 显示文摘 | Kuang G He Q Zhang Y | 2012 | PPAR Res2012，10，1155： | 1 |
| 12 | Graphene oxide as a carbon source for controlled growth of carbon nanowires 显示文摘 | CAO X H HE Q Y SHI W H | 2011 | Small2011，7，9： | 1 |
| 13 | Endogenous amino acid loss at the terminal ileum of rats fed water-extractable or alkali-extractable soluble non-starch polysaccharides obtained from wheat bran when fed with and without xylanase显示文摘 | HE Y H LU W Q PIAO X S | 2006 | Journal of Animal and Veterinary Advances2006，5，8： | 1 |
| 14 | Effect of several organic acids on phosphate adsorption by variable charge soils of central China 显示文摘 | Hu H Q He J Z Li X Y | 2001 | Environment International2001，26，56： | 1 |
| 15 | Experimental study on progressive col- lapse-resistant behavior of reinforced concrete frame structures 显示文摘 | Yi W He Q Xiao Y | 2008 | ACI Structural Journal2008，105，43： | 1 |
| 16 | 3D numerical simulation on shell-and-tube heat exchangers with middle-overlapped helical baffles and continuous baffles-Part II : Simulation results of periodic model and comparison between continuous and noncontinuous helical baffles显示文摘 | Zhang J F He Y L Tao W Q | 2009 | International Journal of Heat and Mass Transfer2009，52，2324： | 1 |
| 17 | Multiferroic BiFeO3 thin films prepared via a simple sol-gel method显示文摘 | Wang Y Jiang Q H He H C | | 0，，14： | 1 |
| 18 | Experimental study on the performance of CO2 residential air-conditioning system with anInternal heat exchanger显示文摘 | Tao Y B He Y L Tao W Q Wu Z G | | 0，，01： | 1 |
| 19 | Microstructure difference between core and skin of T700 carbon fibers in heat-treated carbon/carbon composites显示文摘 | Zhou G S Liu Y Q He L L | 2011 | Carbon2011，49，9： | 1 |
| 20 | Emergence, circulation, and spatiotemporal phylogenetie analysis of eoxsaekievirus a6 - and coxsackievirus al0 - associated hand, foot, and mouth disease infections from 2008 to 2012 in shenzhen, china显示文摘 | He Y Q Chen L Xu W B | 2013 | J Clin Microbiol2013，51，11： | 1 |
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