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| 1 | Performance of N95 elastomeric respirators in high humidity and high coal dust concentration environment显示文摘High humidity and high dust concentration in deep coal mines may severely challenge the performance of respirators worn by coal miners.This paper aims at quantitatively evaluating the respirators used in deep coal mines and providing scientific guidance for the respiratory protection of miners.Based on the self-designed in-situ PM2.5 collector,controllable PM2.5 generator,human breathing simulator,and respirator simulation testing system,under the simulated deep mine working condition,this study investigated the effects of dust loading,wearing time,and dust concentration on the filtration efficiency,breathing resistance,and quality factor of N95 elastomeric respirators.With the increase of dust loading,the respirator filtration efficiency firstly decreased,then increased(minimum value 97.5%).The breathing resistance increased exponentially from 120 to 180 to 1020-1530 Pa,and the quality factor decreased logarithmically from 0.051 to 0.076 to 0.0058-0.0085 Pa^(-1).As the PM2.5 coal dust concentration increased from 5 to 50 mg/m^(3),the wearing time for the respirator breathing resistance to exceed 300 Pa reduced from 7 h to less than 1 h.One N95 elastomeric respirator is not able to perform an 8-h work shift.To avoid the excessive breathing resistance caused by dust loading,more filter cartridges are needed for coal miners. | Jintuo Zhu Xinjian He Liang Wang Xiaoxue Liao Guangping Teng Pengli Jing | 2022 | International Journal of Mining Science and Technology2022，32，1： | 4 |
| 2 | The effects of laser shock peening on fatigue life in Ni-based superalloy显示文摘 | HE Weifeng LI Yinghong QI Pengli | 2010 | Advanced Materials Research2010，135，： | 1 |
| 3 | Developmentof monoclonal antibodies and a competitive ELISA detectionmethod for glycinin,an allergen in soybean显示文摘 | MA Xi SUN Peng HE Pengli | 2010 | Food Chemistry2010，121，： | 1 |
| 4 | Development of monoclonal antibodies and a competitive ELISA detection method for glycinin, an allergen in soybean显示文摘 | MA Xi SUN Peng HE Pengli | 2010 | Food Chemistry2010，121，： | 1 |
| 5 | Atrial Fibrillation Induces Myo- cardial Fibrosis Through Angiotensin Ⅱ Type 1 Receptor-Specific Arkadia-Mediated Downregulation of Smad7 显示文摘 | He XY GaoXR PengLY | 2011 | Cire Res2011，108，2： | 1 |
| 6 | Engineered poly(A)-surrogates for translational regulation and therapeutic biocomputation in mammalian cells显示文摘Here,we present a gene regulation strategy enabling programmable control over eukaryotic translational initiation.By excising the natural poly-adenylation(poly-A)signal of target genes and replacing it with a synthetic control region harboring RNA-binding protein(RBP)-specific aptamers,cap-dependent translation is rendered exclusively dependent on synthetic translation initiation factors(STIFs)containing different RBPs engineered to conditionally associate with different eIF4F-binding proteins(eIFBPs).This modular design framework facilitates the engineering of various gene switches and intracellular sensors responding to many user-defined trigger signals of interest,demonstrating tightly controlled,rapid and reversible regulation of transgene expression in mammalian cells as well as compatibility with various clinically applicable delivery routes of in vivo gene therapy.Therapeutic efficacy was demonstrated in two animal models.To exemplify disease treatments that require on-demand drug secretion,we show that a custom-designed gene switch triggered by the FDA-approved drug grazoprevir can effectively control insulin expression and restore glucose homeostasis in diabetic mice.For diseases that require instantaneous sense-and-response treatment programs,we create highly specific sensors for various subcellularly(mis)localized protein markers(such as cancer-related fusion proteins)and show that translation-based protein sensors can be used either alone or in combination with other cell-state classification strategies to create therapeutic biocomputers driving self-sufficient elimination of tumor cells in mice.This design strategy demonstrates unprecedented flexibility for translational regulation and could form the basis for a novel class of programmable gene therapies in vivo. | Jiawei Shao Shichao Li Xinyuan Qiu Jian Jiang Lihang Zhang Pengli Wang Yaqing Si Yuhang Wu Minghui He Qiqi Xiong Liuqi Zhao Yilin Li Yuxuan Fan Mirta Viviani Yu Fu Chaohua Wu Ting Gao Lingyun Zhu Martin Fussenegger Hui Wang Mingqi Xie | 2024 | Cell Research2024，34，1： | 0 |
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