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| 1 | Management of borderline and locally advanced pancreatic cancer:Where do we stand?显示文摘Many patients with pancreas cancer present with locally advanced pancreatic cancer(LAPC).The principle tools used for diagnosis and staging of LAPC include endoscopic ultrasound,axial imaging with computed tomography and magnetic resonance imaging,and diagnostic laparoscopy.The definition of resectability has historically been vague,as there is considerable debate and controversy as to the definition of LAPC.For the patient with LAPC,there is some level of involvement of the surrounding vascular structures,which include the superior mesenteric artery,celiac axis,hepatic artery,superior mesenteric vein,or portal vein.When feasible,most surgeons would recommend possible surgical resection for patients with borderline LAPC,with the goal of an R0 resection.For initially unresectable LAPC,neoadjuvant should be strongly considered.Specifically,these patients should be offered neoadjuvant therapy,and the tumor should be assessed for possible response and eventual resection.The efficacy of neoadjuvant therapy with this approach as a bridge to potential curative resection is broad,ranging from 3%-79%.The different modalities of neoadjuvant therapy include sin-gle or multi-agent chemotherapy combined with radiation,chemotherapy alone,and chemotherapy followed by chemotherapy with radiation.This review focuses on patients with LAPC and addresses recent advances and controversies in the field. | Jin He Andrew J Page Matthew Weiss Christopher L Wolfgang Joseph M Herman Timothy M Pawlik | 2014 | World Journal of Gastroenterology2014，20，9： | 11 |
| 2 | 煤灰沉积的传热过程模型及其数值研究显示文摘计算流体力学(CFD)方法的应用在锅炉设计或燃烧设备的改造过程中有着十分重要的作用.本文研究了实际燃烧过程中普遍存在的煤灰沉积现象对数值计算结果的影响,提出了描述煤灰沉积的新型传热模型,比较了新模型采用前后数值计算结果与实测数据的差异,从而验证了该模型的合理性,提高了对炉内积灰、结渣过程数值描述的精度. | 徐明厚 郑楚光 HE X G AZEVEDO J L T CARVALHO M G | 2002 | 工程热物理学报2002，23，1： | 10 |
| 3 | 16年随访的前瞻性队列中521120名个体的膳食脂肪摄入与总死亡率和特定原因死亡率的关系显示文摘饱和脂肪摄入与心血管健康相关性的证据存在争议。不饱和脂肪和总死亡率及心血管病死亡率的相关性存在不一致性,并且关于非心血管病死亡率的数据较少。该文旨在评估膳食脂肪与总死亡率和特定原因死亡率的关系。方法和结果:研究者分析了来自随访16年的美国国立卫生研究院一美国退休人员协会膳食与健康研究年龄50~71岁的参与者521 120人的数据。通过食品频率问卷评估饱和脂肪酸(saturatedfatty acid,SFA )、反式脂肪酸(trans-fatty acid,TFA)、单不饱和脂肪酸(monounsaturated fatty acid,MUFA)与多不饱和脂肪酸(polyunsaturated fattyacid,PUFA)的摄入量。 | 陈嘉睿(译) 练桂丽(审校) Zhuang P Zhang Y He W Chen X Chen J He L Mao L Wu F Jiao J | 2019 | 中华高血压杂志2019，27，4： | 7 |
| 4 | Induction of mucosal and systemic immune response by single-dose oral immunization with biodegradable microparticles containing DNA encoding HBsAg显示文摘 | He XW Wang F Jiang L Li J Liu SK Xiao ZY Jin XQ Zhang YN He Y Li K Guo YJ Sun SH | 2005 | 第二军医大学学报2005，26，10： | 5 |
| 5 | Rho/Rock signal transduction pathway is required for MSC tenogenic differentiation显示文摘Mesenchymal stem cell(MSC)-based treatments have shown promise for improving tendon healing and repair.MSCs have the potential to differentiate into multiple lineages in response to select chemical and physical stimuli, including into tenocytes. Cell elongation and cytoskeletal tension have been shown to be instrumental to the process of MSC differentiation. Previous studies have shown that inhibition of stress fiber formation leads MSCs to default toward an adipogenic lineage, which suggests that stress fibers are required for MSCs to sense the environmental factors that can induce differentiation into tenocytes. As the Rho/ROCK signal transduction pathway plays a critical role in both stress fiber formation and in cell sensation, we examined whether the activation of this pathway was required when inducing MSC tendon differentiation using rope-like silk scaffolds. To accomplish this, we employed a loss-of-function approach by knocking out ROCK,actin and myosin(two other components of the pathway) using the specific inhibitors Y-27632, Latrunculin A and blebbistatin, respectively. We demonstrated that independently disrupting the cytoskeleton and the Rho/ROCK pathway abolished the expression of tendon differentiation markers and led to a loss of spindle morphology. Together, these studies suggest that the tension that is generated by MSC elongation is essential for MSC teno-differentiation and that the Rho/ROCK pathway is a critical mediator of tendon differentiation on rope-like silk scaffolds. | Edward Maharam Miguel Yaport Nathaniel L Villanueva Takintope Akinyibi Damien Laudier Zhiyong He Daniel J Leong Hui B Sun | 2015 | Bone Research2015，3，3： | 4 |
| 6 | Mechanical properties of a biodegradable bone regeneration scaffold显示文摘 | Porter B D Oldham J B He S L | 2000 | J Biomech Eng2000，122，3： | 2 |
| 7 | 强化降压对高血压患者左心室肥厚的影响显示文摘目前尚不清楚超出推荐值的强化降压是否更能降低高血压患者的左心室肥厚(left ventricular hypertrophy,LVH)发生风险,以及LVH风险降低能否解释强化降压的益处。Soliman等纳入收缩压干预试验(systolic blood pressure intervention,SPRINT)中患有高血压但无糖尿病的8164例受试者(平均年龄67.9岁,女性35.3%,31.2%为非洲裔), | 刘莉 叶鹏 Soliman EZ Ambrosius WT Cushman WC Zhang ZM Bates JT Neyra JA Carson TY Tamariz L Ghazi L Cho ME Shapiro BP He J Fine LJ Lewis CE SPRINT Research Study Group | 2017 | 中华高血压杂志2017，25，6： | 2 |
| 8 | Image enhancement and minutiae matching in fingerprint verification显示文摘 | He Y L Tian J Luo X P | 2003 | Pattem Recognition Letters2003，24，910： | 1 |
| 9 | Aerobic and anaerobic biodegradation of nonylphenol ethoxylates in estuary sediment of Yangtze River, China显示文摘 | LU J HE Y L WU J | 2009 | Environ Geol2009，57，1： | 1 |
| 10 | Test results for three prototype models of a linear induction launcher显示文摘 | Zabar Z Lu X N He J L | 1991 | IEEE Transactions on Magnetics1991，27，1： | 1 |
| 11 | A new mixed micellar electrokinetic chromatography method for analysis of natural and synthetic anabolic steroids 显示文摘 | Zhang L Chen J He Y eZ al | 2009 | Talanta2009，77，3： | 1 |
| 12 | Modified fast climbing search auto-focus algorithm with adaptive step size searching technique for digital camera显示文摘 | HE J ZHOU R Z HONG Z L | 2003 | Journal of IEEE Transactions on Consumer Electronics2003，49，2： | 1 |
| 13 | Experimental observations on the mechanical properties of nanoscale ceramic/Teflon multilaters显示文摘 | HE J L WANG L D LI W Z | 1998 | Mater Chem Phys1998，54，13： | 1 |
| 14 | Dissolved organic matter (DOM) in recycled leachate of bioreactor landfill 显示文摘 | He P J Xue J F Shao L M | 2006 | Water Res2006，40，7： | 1 |
| 15 | Maps preserving numerical radius of products of self-adjoint operators显示文摘 | He K Hou J C Zhang X L | 2010 | Acta Math Sinca-Eng-lish Series2010，6，： | 1 |
| 16 | Modeling and simulation for hybrid electric vehicles-part II: simulation显示文摘 | HE X L HODGSON J W | 2002 | IEEE Transaction on Intelligent Transportation Systems2002，3，4： | 1 |
| 17 | Thermal stability of recorded information at high densities显示文摘 | Charap S H Lu P L He Y J | 1997 | IEEE Trans Magn1997，33，1： | 1 |
| 18 | 显示文摘 | He P Liu M Luo J L | 2002 | Journal of the Electrochemical Society2002，149，7： | 1 |
| 19 | Mitochondrial permeability transition: a common pathway to necrosis and apoptosis显示文摘 | Kim J S He L Lemasters J J | 2003 | Biochem Biophys Res Commun2003，304，3： | 1 |
| 20 | Promotion of photodynamic therapy-induced apoptosis by stress kinases显示文摘 | Xue L He J Oleinick NL | 1999 | Cell Death Differ1999，6，9： | 1 |
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