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| 1 | 体内腺相关病毒-常间回文重复序列丛集及其相关蛋白9介导的基因编辑可改善家族性高胆固醇血症的动脉粥样硬化显示文摘低密度脂蛋白受体(low-density lipoprotein receptor,Ldlr)基因突变是家族性高胆固醇血症的主要原因之一,可导致动脉粥样硬化,并具有很高的终生心血管病风险。常间回文重复序列丛集(clustered regularly interspaced short palindromic repeats,CRISPR)/CRISPR相关蛋白9(CRISPR-related protein 9,Cas9)系统是基因编辑纠正基因突变从而改善疾病的有效工具。该研究的目的是通过腺相关病毒(adeno-associated virus,AAV)携带的CRISPR/Cas9系统进行体内体细胞基因编辑,以确定其能否在小鼠模型中治疗由Ldlr突变体引起的家族性高胆固醇血症。 | 刘青(译) 叶鹏(审校) Zhao H Li Y He L Pu W Yu W Li Y Wu YT Xu C Wei Y Ding Q Song BL Huang H Zhou B | 2020 | 中华高血压杂志2020，28，3： | 22 |
| 2 | Electrodeposition of Pt-Ru nanoparticles on carbon nanotubes and their electrocatalytic properties for methanol electrooxidation 显示文摘 | He Z B Chen J H Liu D Y | 2004 | Diamond and Related Materials2004，13，10： | 1 |
| 3 | disturbance attenuation for state delayed systems 显示文摘 | Wang Q G Lee T H | 1998 | System & Control Letters1998，33，： | 1 |
| 4 | Carbohydrates from Cynanchum otophyllum 显示文摘 | Zhao Y B Shen Y M He H P | 2004 | Carbohydrate Research2004，339，11： | 1 |
| 5 | lntracellular trehalose improves the survival of human red blood cells by freeze-drying显示文摘 | He H Liu B L Hua Z Z et aI | 2007 | Ener- gy Power Eng2007，1，1： | 1 |
| 6 | Distribution, degradation and dynamics of dissolved organic carbon and its major compound classes in the Pearl River estuary, China显示文摘 | HE B Y DAI M H ZHAI W D | 2010 | Marine Chemistry2010，119，14： | 1 |
| 7 | Mechanical properties of single crystal tungsten microwhiskers characterized by nanoindentation 显示文摘 | HUANG H WU Y Q WANG S L HE Y H ZOU J HUANG B Y LIU C T | 2009 | Materials Science and Engeering A2009，53，12： | 1 |
| 8 | Compliant needle modeling and steerable insertion simulation 显示文摘 | Tang L B Chen Y H He X J | 2008 | Computer-Aided Design and Applications2008，5，1234： | 1 |
| 9 | An innovative design for using flexible printed coils for magnetostrictive-based longitudinal guided wave sensors in steel strand inspection显示文摘 | Tse P W Liu X C Liu Z H Wu B He C F Wang XJ | 2011 | Smart Materials and Structures2011，20，05： | 1 |
| 10 | Computed tomography evaluation of right heart dysfunction in patients with acute pulmonary embolism显示文摘 | He H Stein Mw Zalta B et a1 | 2006 | J Comput Assist Tomogr2006，30，2： | 1 |
| 11 | The TIL commissioning and performance显示文摘 | X Zhang W Zheng X Wei F Jing Z Sui K Zheng Q Xu X Yuan X Jiang L Yang P Ma M Li J Wang D Hu S He F Li Z Peng B Feng H Zhou L Guo X Li X Zhang J Su Q Zhu H Yu R Zhao C Ma H He D Fan W Zhang | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 12 | Spectroelectrochemistry of solid in-dirubin and its sulfdnated form显示文摘 | Hu X W He J B You Y H | 2011 | Electrochim Acta2011，56，3： | 1 |
| 13 | A continuum model for size-dependent deformation of elastic films of nanoscale thickness显示文摘 | He L H Lim C W Wu B S | 2004 | International Journal of Solids and Structures2004，41，： | 1 |
| 14 | Novel KOH electrolyte for one-step electrochemical synthesis of high purity solid K2FeO4:Comparison with NaOH 显示文摘 | He W C Wang J M Shao H B | 2005 | Electrochemistry Communications2005，7，6： | 1 |
| 15 | Mango malformation disease in South China caused by Fus arium p roliferotum显示文摘 | ZHAN R L YANG S J HO H H LIU F ZHAO Y L CHANG J M HE Y B | 2010 | Journal of Phytopathology2010，158，： | 1 |
| 16 | Modeling the runoff and glacier mass balance in a small watershed on the Central Tibetan Plateau, China, from 1955 to 2008显示文摘 | GAO H HE X YE B | 2012 | Hydrological Processes2012，26，11： | 1 |
| 17 | Natural variation in GS5 plays an important role in regulating grain size and yield in rice显示文摘 | Li Y B Fan C C Xing Y Z Jiang Y H Luo L J Sun L Shao D Xu C J Li X H Xiao J H He Y Q Zhang Q F | 2011 | Nature genetics2011，2，43： | 1 |
| 18 | Formation mechanism and oxidation behavior of MoSi2-SiC protective coating prepared by chemical vapor infiltration/reaction显示文摘 | He Z B Li H J Shi X H | 2013 | Trans Nonfer- rous Metals Soc China2013，23，7： | 1 |
| 19 | Nanocelluloses as innovative polymers in research and application显示文摘 | Klemm D Schumann D Kramer F He(B)ler N Hornung M Schmauder H P Marsch S | | 0，，09： | 1 |
| 20 | Antimicrobial,cytotoxic lignans and terpenoids from the twigs ofPseudolarix kaempferi 显示文摘 | He W J Chu H B Zhang Y M | 2011 | Planta Med2011，77，17： | 1 |
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