|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 2 | A probabilistic reasoning-based decision support system for selecting remediation technologies for petroleum-contaminated sites 显示文摘 | HE L CHAN C W HUANG G H ZENG G M | 2006 | Expert Systems with Applications2006，30，4： | 1 |
| 3 | Speciation of heavy metals in marine sediments from the East China Sea by ICP-MS with sequential extraction显示文摘 | Yuan C G Shi J B He B | 2004 | Environment International2004，30，： | 1 |
| 4 | Effect of brain e dema on infarct volume in a focal cerebral ischemia model in rats显示文摘 | Lin T N He Y Y Wu G Khan M Hsu C Y | 1993 | Stroke1993，24，： | 1 |
| 5 | Delay-range-dependent stability for systems with time-varying delay显示文摘 | He Y Wang Q G Lin C | 2007 | Automatica2007，43，： | 1 |
| 6 | Newly synthesized dyes and their polymer/Glass composites for one-and two-photon pumped solid-state cavity lasing显示文摘 | Zhao C F He G S Bhawalkar J D | 1995 | Chem Mater1995，，7： | 1 |
| 7 | Sea surface temperature variability in the north side of the South China Sea over the last 55 years revealed by coral δ^18O records显示文摘 | Peng Z C He J F Chen T G | 2003 | Geochimica et Cosmochimica Acta2003，67，18： | 1 |
| 8 | Modeling Rotor Wake Dynamics with Vis- cous Vortex Particle Method 显示文摘 | He C J Zhao J G | 2009 | AIAA Journal2009，47，4： | 1 |
| 9 | Effects of a purified sap-onin miture from alfalfa on plasma lipid metabolism in hyperlipidemic mice 显示文摘 | Yu C H Xie G He R R | 2011 | Journal of Health Science2011，57，5： | 1 |
| 10 | Nonlinear solution for vibration of vertical elastic plate by initial elevation of free surface 显示文摘 | HE G KASHIWAGI M HU C | 2010 | International Jourual of Offshore and Polar Engineering2010，22，1： | 1 |
| 11 | The determination of chlorogenic acid in cigarettes by inhibited chemiluminescence analysis显示文摘 | He C Cui H Zhao G | 1997 | Analytica Chimica Acta1997，351，： | 1 |
| 12 | Modeling rotor wake dynamics with viscous vortex particle method显示文摘 | He C J Zhao J G | 2009 | AIAA Journal2009，47，4： | 1 |
| 13 | Study on the clinical efficacy of Human Urinary Kalllikrein in the treatment of acute cerebral infarction according to TOAST classification显示文摘 | Li C Zhao G He QY | 2015 | Pak J Pharm Sci2015，28，4： | 1 |
| 14 | Regeneration of full-scale commercial honeycomb monolith catalyst(V2O5-WO3/Ti O2)used in coal-fired power plant显示文摘 | SHANG X S HU G R HE C | 2012 | J Ind Eng Chem2012，18，51： | 1 |
| 15 | Microstructures and proper- ties of SnZn lead-free solder joints bearing La for electronic pack- aging显示文摘 | Zhang L Han J G He C W | 2012 | IEEE Transactions on Electron Devices2012，59，12： | 1 |
| 16 | Microstructure and mechanical properties of reactive sputtered nanocrystalline (Ti,AI)N fihns 显示文摘 | HE C L ZHANG J L SONG G H | 2015 | Thin Solid Films2015，584，： | 1 |
| 17 | High corrosion-resistance nanocrystalline Ni coating on AZ91D magnesium alloy显示文摘 | LIAN J S HE J G | 2006 | Surf Coat Technol2006，200，1819： | 1 |
| 18 | Neural network based L1-norm optimization approach for fault diagnosis of nonlinear circuits with tolerances显示文摘 | HE Y G SUN Y C | 2001 | IEE Proceedings of Circuits Device and Systems2001，148，2： | 1 |
| 19 | Transiugular intrahe- patic portosystemic shunt for portal vein thrombosis with symptomatic portal hypertension in liver cirrhosis 显示文摘 | Han G H Qi X S He C G | 2011 | J Hepatol2011，54，1： | 1 |
| 20 | Effects of a purified saponin mixture from alfalfa on plasma lipid metabolism in hyperlipi- demic miee显示文摘 | Yu C H Xie G He R R etal | 2011 | Journal of Health Science2011，57，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员