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| 1 | 研究、综述、摘要、总结、系统:循证卫生保健决策的“5S”信息服务演进显示文摘要成功开展循证卫生保健,很大程度上依赖于对当前疾病诊断、治疗、预防方面最佳证据的可及性,最好能够根据个体患者或人群的特征和所处环境,以及医疗卫生资源,制定相应的卫生保健措施。尽管现有的信息资源远未尽善尽美,但过去十年间已取得了长足的进步,目前已有一系列出色的信息服务可用于多种卫生保健决策。循证卫生保健的提供者和用户可通过最成熟的信息服务,为各自关心的问题找到当前最佳证据。 | R. Brian Haynes 陈耀龙(译) 刁骧(审校) | 2007 | 中国循证医学杂志2007，7，5： | 21 |
| 2 | 慢性牙周炎中核因子κB受体活化子、护骨素和肿瘤坏死因子-α的蛋白表达显示文摘目的 比较慢性牙周炎牙槽骨吸收处肉芽组织中的核因子κB受体活化子 (RANKL)、护骨素 (OPG)和肿瘤坏死因子(TNF) -α的水平 ,研究慢性牙周炎牙槽骨吸收与这些调节因子间的关系。方法 应用鼠抗人单克隆抗体、半定量分析及数字成像技术分析慢性牙周炎组织中RANKL、OPG和TNF α的蛋白表达。结果 慢性牙周炎牙槽骨吸收处肉芽组织中有较高的RANKL和TNF α蛋白表达 ,OPG蛋白表达相对较低 (P <0 .0 5 ) ;非牙周炎组织中显示较强的OPG蛋白表达和较弱的RANKL和TNF -α蛋白水平 (P <0 .0 5 ) ;OPG蛋白表达与牙周组织中内皮细胞相关。结论 RANKL可能与慢性牙周炎牙槽骨吸收相关 ;RANKL和OPG平衡的变化在慢性牙周炎骨吸收的分子机制中起重要调节作用 ;TNF | 刘琪 David Haynes Mark Bartold | 2004 | 口腔医学2004，24，6： | 15 |
| 3 | Role of polyethylene particles in peri-prosthetic osteolysis:A review显示文摘There is convincing evidence that particles produced by the wear of joint prostheses are causal in the periprosthetic loss of bone,or osteolysis,which,if it progresses,leads to the phenomenon of aseptic loosening.It is important to fully understand the biology of this bone loss because it threatens prosthesis survival,and loosened implants can result in peri-prosthetic fracture,which is disastrous for the patient and presents a difficult surgical scenario.The focus of this review is the bioactivity of polyethylene(PE)particles,since there is evidence that these are major players in the development and progression of osteolysis around prostheses which use PE as the bearing surface.The review describes the biological consequences of interaction of PE particles with macrophages,osteoclasts and cells of the osteoblast lineage,including osteocytes.It explores the possible cellular mechanisms of action of PE and seeks to use the findings to date to propose potential nonsurgical treatments for osteolysis.In particular,a nonsurgical approach is likely to be applicable to implants containing newer,highly cross-linked PEs(HXLPEs),for which osteolysis seems to occur with much reduced PE wear compared with conventional PEs.The caveat here is that we know little as yet about the bioactivity of HXLPE particles and addressing this constitutes our next challenge. | Gerald J Atkins David R Haynes Donald W Howie David M Findlay | 2011 | World Journal of Orthopedics2011，2，10： | 11 |
| 4 | 外科手术核对清单可全球范围内降低手术并发症发生率和手术死亡率(续前)显示文摘背景外科手术已经成为全球卫生保健构成整体所必需的一部分,估计每年实施的手术有2亿3千4百万次之多,手术并发症常见,并常常是可以预防的。我们设想,通过实施一份19项外科手术安全核对清单,以改善手术团队交流和治疗一致性,将会降低手术并发症发生率和手术死亡率。方法于2007年10月至2008年9月间,从8座城市(加拿大的多伦多、印度的新德里、约旦的安曼、新西兰的奥克兰、菲律宾的马尼拉、坦桑尼亚的伊法卡拉、英国的伦敦、华盛顿州的西雅图市)各选取1所医院共计8所医院参加世界卫生组织的'安全手术拯救生命项目',前瞻性地在临床治疗过程中和治疗结束时收集资料,共有3733例年龄16岁或16岁以上的进行非心脏手术的患者入选,随后在引入'外科手术安全核对清单'后收集了连续入选的3955名患者,主要终点事件为手术后30d内的并发症(包括死亡)发生率。结果在引入核对清单前死亡率为1.5%,手术并发症发生率为11.0%,而引入后死亡率和手术并发症发生率分别下降到0.8%(P=0.003)和7.0%(P<0.001)。结论实施外科手术核对清单可以降低不同医院16岁及16岁以上非心脏手术患者的死亡率和并发症发生率。结果在基线资料收集阶段我们入选了3733名患者,实施核对清单后入选3955名患者。表4罗列了这些患者的情况和医院分布,这两个阶段的患者情况没有明显差别。 | Haynes AB Weiser TG Berry WR 丁一妹 孙永华 高建川 | 2009 | 中华损伤与修复杂志(电子版)2009，4，3： | 9 |
| 5 | 循证实践中的医患选择——医疗决策不能迷信证据而要靠人显示文摘 | R Brain Haynes PJ Devereaux Gordon H Guyatt 陈霖 | 2003 | 中国循证医学杂志2003，3，4： | 7 |
| 6 | 二语阅读及词汇教学研究综述显示文摘一、研究状况:目前,有关二语阅读及词汇教学的研究都指明了阅读和词语猜测之间相互作用的本质。这两个互为联系的语言活动,不是完全地“自上而下”或“自下而上”,而是这二者之间相互作用,有机平衡的过程。因此,在这篇综述里,我们就这一观点进行总结,并说明它对教学的含义。首先,这一论点出自于这种教学上的假设,即我们教授学生二语的最终目标,就是要帮助他们在某些应用语言的技巧方面(对许多人而言,最主要的就是阅读技巧)达到近乎母语者的能力。在学校和大学中。 | Thomas Huckin Margot Haynes 黑玉琴 | 1996 | 外语教学理论与实践1996，，2： | 5 |
| 7 | Relative quantification of phosphoproteomic changes in grapevine (Vitis vinifera L.) leaves in response to abscisic acid显示文摘In a previous transcriptomic analysis,abscisic acid(ABA)was found to affect the abundance of a number of transcripts in leaves of Cabernet Sauvignon grapevines with roots that had been exposed to 10μM ABA for 2 h.Other work has indicated that ABA affects protein abundance and protein phosphorylation as well.In this study we investigated changes in protein abundance and phosphorylation of Cabernet Sauvignon grapevine leaves.Protein abundance was assessed by both label-free and isobaric-label quantitive proteomic methods.Each identified common proteins,but also additional proteins not found with the other method.Overall,several thousand proteins were identified and several hundred were quantified.In addition,hundreds of phosphoproteins were identified.Tens of proteins were found to be affected in the leaf after the roots had been exposed to ABA for 2 h,more than half of them were phosphorylated proteins.Many phosphosites were confirmed and several new ones were identified.ABA increased the abundance of some proteins,but the majority of the proteins had their protein abundance decreased.Many of these proteins were involved in growth and plant organ development,including proteins involved in protein synthesis,photosynthesis,sugar and amino-acid metabolism.This study provides new insights into how ABA regulates plant responses and acclimation to water deficits. | Supakan Rattanakan Iniga George Paul A Haynes Grant R Cramer | 2016 | Horticulture Research2016，3，1： | 3 |
| 8 | 自然熟化及施用石膏和有机物质是赤泥堆场修复的关键(英文)显示文摘本文探讨了赤泥堆场生态修复的主要过程。第一个重要过程就是赤泥物理、化学和微生物特性的自然熟化,主要包括:允许剖面排水、干燥、收缩和开裂至一定的深度;表面层可溶性盐、碱和钠的向下溶淋,并通过直接碳酸化进行酸化;抗性植被的自然播种、表层附近有机质的富集以及随之而产生的活性微生物群落的形成。堆场赤泥熟化后,表层施用石膏和有机特质(如粪肥、堆肥、生物固形物),这些改良剂的添加会进一步降低pH,提高钙和其他可交换阳离子的水平,促进钠的溶淋(降低可交换钠离子和ESP),改善赤泥的物理性质、提高微生物的活性。其他重要因素还包括选择合适的耐盐、耐碱及适应当地环境条件的植物种类、施用合适的肥料等。 | HAYNES Richard 周亚凤 | 2019 | Journal of Central South University2019，26，2： | 3 |
| 9 | The Use of High-Performance Fatigue Mechanics and the Extended Kalman/Particle Filters,for Diagnostics and Prognostics of Aircraft Structures显示文摘In this paper,we propose an approach for diagnostics and prognostics of damaged aircraft structures,by combing high-performance fatigue mechanics with filtering theories.Fast&accurate deterministic analyses of fatigue crack propagations are carried out,by using the Finite Element Alternating Method(FEAM)for computing SIFs,and by using the newly developed Moving Least Squares(MLS)law for computing fatigue crack growth rates.Such algorithms for simulating fatigue crack propagations are embedded in the computer program Safe-Flaw,which is called upon as a subroutine within the probabilistic framework of filter theories.Both the extended Kalman as well as particle filters are applied in this study,to obtain the statistically optimal and semi-optimal estimates of crack lengths,from a series of noisy measurements of crack-lengths over time.For the specific problem,a simple modification to the particle filter,which can drastically reduce the computational burden,is also proposed.Based on the results of such diagnostic analyses,the prognostics of aerospace structures are thereafter achieved,to estimate the probabilistic distribution of the remaining useful life.By using a simple example of a single-crack near a fastener hole,we demonstrate the concept and effectiveness of the proposed framework.This paper thus forms the scientific foundation for the recently proposed concepts of VRAMS(Virtual Risk-Informed Agile Maneuver Sustainment)and Digital Twins of aerospace vehicles. | Hai-Kun Wang Robert Haynes Hong-Zhong Huang Leiting Dong Satya N.Atluri | 2015 | Computer Modeling in Engineering & Sciences2015，，5： | 3 |
| 10 | The changing time-series properties of earnings, cash flows and accruals: Has financial reporting become more conservative?显示文摘 | Dan Givoly Carla Hayn | 2000 | Journal of Accounting and Economics2000，，3： | 3 |
| 11 | Barley yield and soil microbial and enzyme activities as affected by contamination of two soils with lead, zinc or copper显示文摘 | O. N. Belyaeva R. J. Haynes O. A. Birukova | 2005 | Biology and Fertility of Soils2005，，2： | 2 |
| 12 | Land-walking vs.water-walking interventions in older adults:Effects on aerobic fitness显示文摘Background:Low cardiorespiratory fitness is an independent predictor of all-cause and cardiovascular mortality,and interventions that increase fitness reduce risk.Water-walking decreases musculoskeletal impact and risk of falls in older individuals,but it is unclear whether water-walking improves aerobic fitness in the same way as weight-dependent land-walking.This randomized controlled trial involved 3 intervention groups—a no-exercise control group(CG),a land-walking(LW)group,and a water-walking(WW)group—to investigate the comparative impacts of LWandWWto CG on fitness.Methods:Both exercise groups attended individually tailored,center-based,intensity-matched 3×weekly sessions for 24 weeks,which progressed to 150 min of exercise per week.This was followed by a 24-week no-intervention period.Maximal graded exercise tests were performed on a treadmill at Weeks 0,24,and 48.Results:Maximal oxygen uptake increased from Week 0 to Week 24 in both exercise groups(0.57±0.62 mL/kg/min,0.03±0.04 L/min for LW;0.93±0.75 mL/kg/min,0.06±0.06 L/min for WW,mean±SE)compared to the CG(-1.75±0.78 mL/kg/min,-0.16±0.05 L/min)(group×time,p<0.05).Time to exhaustion increased significantly following LW only(123.4±25.5 s),which was significantly greater(p=0.001)than the CG(24.3±18.5 s).By Week 48,the training-induced adaptations in the exercise groups returned to near baseline levels.Conclusion:Our study supports current physical-activity recommendations that 150 min/week of moderate-intensity exercise produces improvements in fitness in previously sedentary older individuals.Also,LW andWW elicit similar improvements in fitness if conducted at the same relative intensities.Exercise-na?ve older individuals can benefit from the lower impact forces and decreased risk of falls associated withWWwithout compromising improvements in cardiorespiratory fitness. | Andrew Haynes Louise H.Naylor Howard H.Carter Angela L.Spence Elisa Robey Kay L.Cox Barbara A.Maslen Nicola T.Lautenschlager Nicola D.Ridgers Daniel J.Green | 2020 | Journal of Sport and Health Science2020，9，3： | 2 |
| 13 | 利用Arecibo射电望远镜河外21-cm巡天数据进行中性氢吸收线的探测研究显示文摘利用Arecibo射电望远镜40%的ALFALFA(Arecibo Legacy Fast Arecibo L-band Feed Array)河外中性氢巡天数据,探讨了进行中性氢吸收线'盲寻'的过程与方法,并给出了搜寻吸收线的一些初步结果:(1)探测到的中性氢吸收源的数量共有10个,其中5个为文献中已知源,其余新发现的吸收线源需要进一步的研究与证实.(2)利用探测灵敏度给出了探测区域中性氢柱密度的上限,这些上限的频率统计分布显示阻尼莱曼α吸收线系统(DLAs)中的中性氢气体的平均自旋温度与覆盖因子的比值Ts/f很可能大于500K.射电干扰与驻波是影响Arecibo河外中性氢吸收线探测的两个重要因素,也将进行一定的分析以及讨论相应的解决方法等.正在建设中的500 m口径射电望远镜FAST(The Five-hundred-meter Aperture Spherical Telescope)与Arecibo射电望远镜属于相似类型,但在灵敏度、频带宽度、观测天区范围等方面都将有较大的提高,结合目前的研究进展对将来FAST在中性氢吸收线方面的研究也给出了一定的展望. | 吴忠祖 HAYNES Martha P GIOVANELLI Riccardo 朱明 陈如荣 | 2015 | 天文学报2015，56，2： | 2 |
| 14 | Density functional study of the reaction of O 2 with a single site on the zigzag edge of graphene显示文摘 | Karina Sendt Brian S. Haynes | 2010 | Proceedings of the Combustion Institute2010，，2： | 2 |
| 15 | 临床诊断的证据基础 诊断性研究的构想显示文摘人们已经付出了很大的努力来研究临床医学和科学方法之间的相互关系,以使诊断性试验最有效、最实用。本文重点讨论在诊断性研究中出现的特殊类型的问题以及用以解决上述问题的研究构想(将这些临床问题转化成适当的研究计划)。举一个例子,我们将评价一下脑钠素(BNP) | D L Sackett R B Haynes 陈雷 | 2003 | 英国医学杂志中文版2003，6，3： | 2 |
| 16 | Reninoma: case report and literature review显示文摘 | Lara Wong Thomas HS Hsu Mark G Perlroth Lawrence V Hofmann Claudia M Haynes Laurence Katznelson | 2008 | Journal of Hypertension2008，，2： | 2 |
| 17 | 使用非侵入的神经影像方法解码人类思维显示文摘随着神经影像技术的发展,'读脑机器'在不久的将来可能会变成现实。在众多实现'读脑机器'的技术中,使用基于血氧水平依赖的脑功能磁共振技术的神经解码方法则是非常有希望的一种技术。在本报告中,我们结合我们实验室最近开展的两个研究工作,说明了使用功能磁共振技术进行神经解码的一般方法及其应用。本领域的发展很快,所有的这些工作让我们对发明'读脑机器'充满了期待。但是,与此同时,我们也应该看到目前还存在着很多技术的局限和挑战。本报告的最后,我们也对这些局限和挑战进行了一些讨论。 | HAYNES John-Dylan | 2009 | 生命科学2009，21，2： | 2 |
| 18 | 循证医学进展下一个十年将同样精彩显示文摘 | Gordon Guyatt Deborah Cook Brian Haynes 廖加群 | 2005 | 中国循证医学杂志2005，5，8： | 2 |
| 19 | Agency Costs, Risk Management, and Capital Structure显示文摘 | Hayne E.Leland | 2002 | The Journal of Finance2002，，4： | 2 |
| 20 | Effects of lime and phosphate additions on changes in enzyme activities, microbial biomass and levels of extractable nitrogen, sulphur and phosphorus in an acid soil显示文摘 | R. J. Haynes R. S. Swift | 1988 | Biology and Fertility of Soils1988，，2： | 2 |
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