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| 1 | 口腔医疗行业中的新型职业--数字化牙科技师显示文摘随着数字化、信息化科技及互联网技术在口腔医疗领域的广泛应用,传统口腔医疗模式和义齿加工制作模式正在面临着革命性的改变。应用数字诊断技术,口腔扫描仪、3D打印系统、数字引导种植牙、显微镜下超薄美容牙、义齿注塑系统、口腔数字化CT扫描等国际化新技术、新方法,从而全面提升口腔医疗模式和义齿加工制作模式技术的整体水平,正式进入了一个数字化的口腔医疗和义齿制作的新时代。 | 王丹 李刚 John Haupt 程昕 常亮 | 2018 | 全科口腔医学电子杂志2018，5，25： | 5 |
| 2 | Less common etiologies of exocrine pancreatic insufficiency显示文摘Exocrine pancreatic insufficiency(EPI), an important cause of maldigestion and malabsorption, results from primary pancreatic diseases or secondarily impaired exocrine pancreatic function. Besides cystic fibrosis and chronic pancreatitis, the most common etiologies of EPI, other causes of EPI include unresectable pancreatic cancer, metabolic diseases(diabetes); impaired hormonal stimulation of exocrine pancreatic secretion by cholecystokinin(CCK); celiac or inflammatory bowel disease(IBD) due to loss of intestinal brush border proteins; and gastrointestinal surgery(asynchrony between motor and secretory functions, impaired enteropancreatic feedback, and inadequate mixing of pancreatic secretions with food). This paper reviews such conditions that have less straightforward associations with EPI and examines the role of pancreatic enzyme replacement therapy(PERT). Relevant literature was identified by database searches. Most patients with inoperable pancreatic cancer develop EPI(66%-92%). EPI occurs in patients with type 1(26%-57%) or type 2 diabetes(20%-36%) and is typically mild to moderate; by definition, all patients with type 3 c(pancreatogenic) diabetes have EPI. EPI occurs in untreated celiac disease(4%-80%), but typically resolves on a gluten-free diet. EPI manifests in patients with IBD(14%-74%) and up to 100% of gastrointestinal surgery patients(47%-100%; dependent on surgical site). With the paucity of published studies on PERT use for these conditions, recommendations for or against PERT use remain ambiguous. The authors conclude that there is an urgent need to conduct robust clinical studies to understand the validity and nature of associations between EPI and medical conditions beyond those with proven mechanisms, and examine the potential role for PERT. | Vikesh K Singh Mark E Haupt David E Geller Jerry A Hall Pedro M Quintana Diez | 2017 | World Journal of Gastroenterology2017，23，39： | 5 |
| 3 | The role of MDM2 and MDM4 in breast cancer development and prevention显示文摘从乳癌的死亡的主要原因不是主要的瘤,而是 relapsing,药抵抗的、变形疾病。识别贡献好攻击的癌症的因素为治疗提供重要领先。对致癌物的固有的防卫取决于每个人的单个分子的组成。这些回答的重要分子的决定因素在鼠标的控制下面是两倍分钟(MDM ) 家庭:蛋白质 MDM2 和 MDM4 包括了。对应力和随后的恢复的在正常、健康成年房间,极其调整的 MDM 家庭功能测量的、细胞的回答。MDM 家庭的合适的功能为正常的胸开发,而且为保存 genomic 忠实是重要的。MDM 家庭成员最好被描绘让他们主要的瘤 suppressor p53 的否定规定调制压力回答。他们另外的细胞的管理者上的影响正在出现。MDM 家庭的不适当地提高的蛋白质层次高度与癌症发生的增加的风险被联系。是的 MDM 家庭成员的探索癌症治疗学的目标为设计定制的反癌症治疗是相关的,但是成功的途径必须战略上在目标癌症和邻近的健康房间和纸巾上考虑影响。这评论集中于在正常、恶意的胸房间与 MDM 家庭的角色相关的最近的调查结果。 | Sue Haupt Reshma Vijayakumaran Panimaya Jeffreena Miranda Andrew Burgess Elgene Lim Ygal Haup | 2017 | Journal of Molecular Cell Biology2017，9，1： | 3 |
| 4 | Thinned arrays using genetic algorithm显示文摘 | Randy L Haupt | 1994 | IEEE Transactions on Antenna and Propagation1994，42，7： | 2 |
| 5 | Lithium beyond psychiatric indications:the reincarnation of a new old drug显示文摘Lithium has been used in the treatment of bipolar disorders for decades,but the exact mechanisms of action remain elusive to this day.Recent evidence suggests that lithium is critically involved in a variety of signaling pathways affecting apoptosis,inflammation,and neurogenesis,all of which contributing to the complex pathophysiology of various neurological diseases.As a matter of fact,preclinical work reports both acute and longterm neuroprotection in distinct neurological disease models such as Parkinson’s disease,traumatic brain injury,Alzheimer’s disease,and ischemic stroke.Lithium treatment reduces cell injury,decreasesα‑synuclein aggregation and Tau protein phosphorylation,modulates inflammation and even stimulates neuroregeneration under experimental conditions of Parkinson’s disease,traumatic brain injury,and Alzheimer’s disease.The therapeutic impact of lithium under conditions of ischemic stroke was also studied in numerous preclinical in vitro and in vivo studies,giving rise to a randomized double-blind clinical stroke trial.The preclinic data revealed a lithium-induced upregulation of anti-apoptotic proteins such as B-cell lymphoma 2,heat shock protein 70,and activated protein 1,resulting in decreased neuronal cell loss.Lithium,however,does not only yield postischemic neuroprotection but also enhances endogenous neuroregeneration by stimulating neural stem cell proliferation and by regulating distinct signaling pathways such as the RE1-silencing transcription factor.In line with this,lithium treatment has been shown to modulate postischemic cytokine secretion patterns,diminishing microglial activation and stabilizing blood-brain barrier integrity yielding reduced levels of neuroinflammation.The aforementioned observations culminated in a first clinical trial,which revealed an improved motor recovery in patients with cortical stroke after lithium treatment.Beside its well-known psychiatric indications,lithium is thus a promising neuroprotective candidate for the aforementioned neurological diseases.A detailed understanding of the lithium-induced mechanisms,however,is important for prospective clinical trials which may pave the way for a successful benchto-bedside translation in the future.In this review,we will give an overview of lithiuminduced neuroprotective mechanisms under various pathological conditions,with special emphasis on ischemic stroke. | Matteo Haupt Mathias Bähr Thorsten R.Doeppner | 2021 | Neural Regeneration Research2021，16，12： | 2 |
| 6 | 中美牙科技师市场现状分析显示文摘没有什么企业是可以工作一辈子的,不过职业却可以保持一辈子。让你了解什么是牙科技师过去、现在和将来。以及中美两国牙科技师市场需求,为你职业规划和定位的重要性,助你走向明确的人生。要去争取从事的职业类型,选择职业目标。 | Liang Chang 李刚 John Haupt | 2019 | 全科口腔医学电子杂志2019，6，4： | 2 |
| 7 | Phase-only adaptive nulling with a genetic algorithm显示文摘 | Randy L Haupt | 1997 | IEEE Transactions on Antenna and Propagation1997，45，6： | 2 |
| 8 | Patent indicators for the technology life cycle development 显示文摘 | HAUPT R KLOYER M LANGE M | 2007 | Research Policy2007，36，： | 1 |
| 9 | High-throughput viral expression of cDNA-green fluorescent protein fusions reveals novel subcellular addresses and identifies unique proteins that interact with plasmodesmata 显示文摘 | ESCOBAR N M HAUPT S THOW G | 2003 | The Plant Cell2003，15，： | 1 |
| 10 | Electrophysiological signature of working and long-term memory interaction in the human hip-pocampus显示文摘 | Axmacher N Lenz S Haupt S | 2010 | EurJ Neurosci2010，31，1： | 1 |
| 11 | Fractal antenna engineering: The theory and design of fractal antenna arrays显示文摘 | WERNER D H HAUPT R L WERNER P L | 1999 | IEEE Antennas Propagat Mag1999，41，5： | 1 |
| 12 | High-throughput viral expression of cDNA-green fluorescent protein fusions reveals novel subcellular addresses and identifies unique proteins that interact with plasmodesmata显示文摘 | Escobar N M Haupt S Thow G | 2003 | Plant Cell2003，15，： | 1 |
| 13 | Apoptosis -the p53 network显示文摘 | HAUPT S BERGER M | 2003 | J Cell Sci2003，116，20： | 1 |
| 14 | Patent indicators for the technology life cycle development 显示文摘 | Haupt R Kloyer M Laage M | 2007 | Research Policy2007，36，3： | 1 |
| 15 | Toeplitz compressedsensing matrices with applications to sparse channelestimation 显示文摘 | Haupt J Bajwa W U Raz G | 2010 | IEEE Transactions on InformationTheory2010，56，11： | 1 |
| 16 | Temporal profile of connexin 43 expression after photothrombotic lesion in rat brain 显示文摘 | Haupt C Witte OW Frahm C | 2007 | Neuroscience2007，144，： | 1 |
| 17 | Role of the apolipoprotein E and catechol - 0 - methyltransferase genes in prospective and ret- rospective memory traits 显示文摘 | Donges B Haupt LM Lea RA | 2012 | Gene2012，506，1： | 1 |
| 18 | Bmi1 transgene induces lymphomas and collaborates with myc in tumorigenesis显示文摘 | Haupt Y Bath M L Harris A W | 1993 | Oncogene1993，8，11： | 1 |
| 19 | Patent Indicators for the Technol- ogy Life Cycle Development显示文摘 | Haupt R Kloyer M Lange M | 2007 | Research Policy2007，，36： | 1 |
| 20 | Sequential treatment ofGuillain-Barr6 syndrome with extracorporeal elimination and intravenous immunoglobulin 显示文摘 | Haupt WF Rosenow F van der Ven C | 1996 | J Neurol Sci1996，137，2： | 1 |
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