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| 1 | Multimodality functional imaging using DW-MRI and 18F-FDG-PET/CT during radiation therapy for human papillomavirus negative head and neck squamous cell carcinoma: Meixoeiro Hospital of Vigo Experience显示文摘AIM To noninvasively investigate tumor cellularity measured using diffusion-weighted magnetic resonance imaging(DW-MRI) and glucose metabolism measured by 18 Flabeled fluorodeoxyglucose positron emission tomography/computed tomography(18F-FDG-PET/CT) during radiation therapy(RT) for human papillomavirus negative(HPV-) head and neck squamous cell carcinoma(HNSCC).METHODS In this prospective study, 6 HPV- HNSCC patients underwent a total of 34 multimodality imaging examinations(DW-MRI at 1.5 T Philips MRI scanner [(n = 24) pre-, during-(2-3 wk), and post-treatment(Tx), and 18F-FDG PET/CT pre- and post-Tx(n = 10)]. All patients received RT. Monoexponential modeling of the DW-MRI data yielded the imaging metric apparent diffusion coefficient(ADC) and the mean of standardized uptake value(SUV) was measured from 18F-FDG PET uptake. All patients had a clinical follow-up as the standard of care and survival status was documented at 1 year.RESULTS There was a strong negative correlation between the mean of pretreatment ADC(ρ =-0.67, P = 0.01) and the pretreatment 18F-FDG PET SUV. The percentage(%) change in delta(?) ADC for primary tumors and neck nodal metastases between pre- and Wk2-3 Tx were as follows: 75.4% and 61.6%, respectively, for the patient with no evidence of disease, 27.5% and 32.7%, respectively, for those patients who were alive with disease, and 26.9% and 7.31%, respectively, for those who were dead with disease.CONCLUSION These results are preliminary in nature and are indicative, and not definitive, trends rendered by the imaging metrics due to the small sample size of HPV- HNSCC patients in a Meixoeiro Hospital of Vigo Experience. | David Aramburu Núnez Antonio Lopez Medina Moisés Mera Iglesias Francisco Salvador Gomez Abhay Dave Vaios Hatzoglou Ramesh Paudyal Alfonso Calzado Joseph O Deasy Amita Shukla-Dave Victor M Munoz | 2017 | World Journal of Radiology2017，9，1： | 2 |
| 2 | The antiproliferative effect of opioid receptor agonists on the T47D human breast cancer cell line is partially mediated through opioid receptors显示文摘 | Hatzoglou A Bakogeorgou E Castanas E | 1996 | Eur J Pharmacol1996，296，2： | 1 |
| 3 | COPD prevalence and the differences between newly and previously diagnosed COPD patients in a spirometry program 显示文摘 | Minas M Hatzoglou C Karetsi E | 2010 | Prim Care Respir J2010，19，4： | 1 |
| 4 | Identification of a novel opioid peptide from human α sl casein显示文摘 | Kampa M Loukas S Hatzoglou A | 1996 | J Biochem1996，319，： | 1 |
| 5 | Identification and characterization of opioid and somato- statin binding sites in the opossum kidney(OK)cell line and their effect on growth显示文摘 | HATZOGLOU A BAKOGEORGOU E PAPAKONSTANTI E | | 0，，04： | 1 |
| 6 | Morphine cross-reacts with somatostatin receptor SSTR2 in the T47D human breast cancer cell line and decreases cell growth 显示文摘 | Hatzoglou A Ouafic LH Bakogeorgou E | 1995 | Cancer Res1995，55，23： | 1 |
| 7 | Tele- metric detection of chronic obstructive pulmonary disease and investigation of quality of life for people working in shipbuilding industry显示文摘 | Koulouri A Gourgoulianis K Hatzoglou C | 2014 | Acta Inform Med2014，22，5： | 1 |
| 8 | Opioid - somatostatin interactions in regulating cancer cell growth 显示文摘 | Hatzoglou A Kampa M Castanas E | 2005 | Front Biosci2005，，10： | 1 |
| 9 | Morphine cross-reacts with somatostatin receptor SSTR2 in the T47D human breast cancer cell line and decreases cell growth显示文摘 | Hatzoglou A Ouafik L Bakogeorgou E | 1995 | Cancer Res1995，55，23： | 1 |
| 10 | COPD charac- teristics and socioeconomic burden in Hellenic correc- tional institutions 显示文摘 | Bania EG Daniil Z Hatzoglou C | 2016 | Int Chron Obstruct Pulmon Dis2016，11，： | 1 |
| 11 | Mitochondrial genes as sites of primary action of steroid hormones显示文摘 | Demonacos CV Karayanni N Hatzoglou E | 1996 | Steroids1996，61，： | 1 |
| 12 | Brain metastases from prostate cancer: an ll-year analysis in the MRI era with emphasis on imaging characteristics, incidence, and prognosis显示文摘 | Hatzoglou V Patel GV Morris MJ | 2014 | J Neuroimaging2014，24，2： | 1 |
| 13 | Gem associates with ezrin and acts via the Rho-GAP Protein Gmip to down-regulate the Rho pathway 显示文摘 | Hatzoglou A Ader I Splingard A | 2007 | Mol Biol Cell2007，18，4： | 1 |
| 14 | Repeatability investigation of reduced field-of-view diffusion-weighted magnetic resonance imaging on thyroid glands显示文摘 | Lu Y Hatzoglou V Banerjee S | 2015 | J Comput Assist Tomogr2015，，： | 1 |
| 15 | Repeatability investigation of reduced field-of-view diffusion-weighted magnetic resonance imaging on thyroid glands显示文摘 | Lu Y Hatzoglou V Banerjee S | 2015 | J Comput Assist Tomogr2015，39，3： | 1 |
| 16 | Using diffusion-weighted MRI to predict aggressive histological features in papillary thyroid carcinoma:a novel tool for pre-operative risk stratification in thy- roid cancer显示文摘 | Lu Y Moreira AL Hatzoglou V | 2015 | Thyroid2015，25，6： | 1 |
| 17 | Regulation of cationic amino acid transport:the story of the CAT-1 transporter显示文摘 | HATZOGLOU M FERNANDEZ J YAMAN I | 2004 | Annu Rev Nutr2004，24，： | 1 |
| 18 | The antiproliferative effect of opioid receptor agonists on the T47D human breast cancer cell line,is partially mediated through opioid receptors显示文摘 | HATZOGLOU A BAKOGEORGOU E CASTANAS E | 1996 | Eur J Pharmacol1996，296，2： | 1 |
| 19 | Mitochondrial genes as sites of primary action of steroid hormones显示文摘 | Demonacos CV Karayanni N Hatzoglou E | 1996 | Steroids1996，61，： | 1 |
| 20 | Identification of a novel opioid peptide (Tyr-Val-Pro-Phe-Pro) derived from human as casein (s-casomorphin, and as-casomorphin amide) 显示文摘 | Kampa M Loukas S Hatzoglou A | 1996 | Biochem J1996，319，： | 1 |
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