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| 1 | On tolerability and safety of a maintenance treatment with 6-thioguanine in azathioprineor 6-mercaptopurine intolerant IBD patients显示文摘AIM: To determine the tolerability and safety profile of a low-dose maintenance therapy with 6-TG in azathioprine (AZA) or 6-mercaptopurine (6-MP) intolerant inflammatory bowel disease (IBD) patients over a treatment period of at least 1 year.METHODS: Database analysis.RESULTS: Twenty out of ninety-five (21%) patients discontinued 6-TG (mean dose 24.6 mg; mean 6-TGN level 540 pmol/8×108 RBC) within 1 year. Reasons for discontinuation were GI complaints (31%), malaise (15%)and hepatotoxicity (15%). Hematological events occurred in three patients, one discontinued treatment. In the 6-TG-tolerant group, 9% (7/75) could be classified as hepatotoxicity. An abdominal ultrasound was performed in 54% of patients, one patient had splenomegaly.CONCLUSION: The majority of AZA or 6-MP-intolerant IBD patients (79%) is able to tolerate maintenance treatment with 6-TG (dosages between 0.3 and 0.4 mg/kg per d). 6-TG may still be considered as an escape maintenance immunosuppressant in this difficult to treat group of patients, taking into account potential toxicity and efficacy of other alternatives. The recently reported hepatotoxicity is worrisome and 6-TG should therefore be administered only in prospective trials. | Nanne KH de Boer Luc JJ Derijks Lennard PL Gilissen Daniel W Hommes Leopold GJB Engels Sybrand Y de Boer Gijsbertus den Hartog Piet M Hooymans Anja BU M(?)kelburg Barend D Westerveld Anton HJ Naber Chris JJ Mulder Dirk J de Jong | 2005 | World Journal of Gastroenterology2005，11，35： | 4 |
| 2 | Low risk aversion encourages the choice for entrepreneurship: an empirical test of a truism显示文摘 | J.S Cramer J Hartog N Jonker C.M Van Praag | 2002 | Journal of Economic Behavior and Organization2002，，1： | 2 |
| 3 | Mechanical Vibrations显示文摘 | Den Hartog J P | 1956 | New York:McGraw-Hill BookCompany Inc 4Th ed1956，1956，： | 1 |
| 4 | Application of the HACCP concept to improve the safety of street foods显示文摘 | Hartog B J Stoots J A M | 1992 | Food Lab News1992，8，2： | 1 |
| 5 | Transmission line vibration due to sleet 显示文摘 | DEN HARTOG J P | 1932 | AIEE Transmission1932，51，4： | 1 |
| 6 | Transmission line vibration due to sleet显示文摘 | Den Hartog J P | 1932 | Trans AIEE1932，51，4： | 1 |
| 7 | Transmission line vibration due to sleet显示文摘 | Den Hartog J P | 1932 | Trans AIEE1932，51，4： | 1 |
| 8 | The insulin-like growth factor 1 receptor in cancer: old focus, new future显示文摘 | Hartog H Wesseling J Boezen HM | 2007 | Eur J Cancer2007，43，13： | 1 |
| 9 | Effects of ultrafine and fine particulate and gaseous air pollution on cardiac autonomic control in subjects with coronary artery disease:the ULTRA study显示文摘 | Timonen KL Vanninen E de Hartog J | 2006 | J Expo Sci Environ Epidemiol2006，16，4： | 1 |
| 10 | If You Are So Smart, Why Aren't You An Entrepreneur Returns to Cognitive and Social Ability: Entrepreneurs Versus Employees显示文摘 | Hartog J Van Praag M Van Der Sluis J | 2010 | Journal of Economics & Management Strategy2010，19，4： | 1 |
| 11 | Tumover of root-derived material and related microbial biomass formation in soils of different texture显示文摘 | Merckx R Den Hartog A Van Veen J | 1985 | Soil Biology and Biochemistry1985，17，4： | 1 |
| 12 | APC in flexible gastrointestinal endoscopy: pilot experiences 显示文摘 | Wahab PJ Mulder C J J den Hartog GD | 1997 | Endoscopy1997，29，： | 1 |
| 13 | Primary shoulder arthmplasty versus conservative treatment for comminuted proximal humeral fractures : a systematic literature review 显示文摘 | den Hartog D de Haan J Sehep NW | 2010 | Open Orthop J2010，4，： | 1 |
| 14 | Molecular identification of the api- cal Ca2+channel in 1,25-dihydroxyvitamin Dz-respon- sive epithelia 显示文摘 | HOENDEROP J G VAN DER KEMP A W C M HARTOG A | 1999 | The Journal of Biological Chemis- try1999，274，13： | 1 |
| 15 | Primary shoulder arthroplasty versus conservative treatment for comminuted proximal humeral fractures: a systematic literature review显示文摘 | Den Hartog D De Haan J Schep NW | 2010 | Open Orthop J2010，4，： | 1 |
| 16 | Health, Wealth and Happiness: Why Pursue a Higher Education?显示文摘 | Hartog J Oosterbeek H | 1998 | Economics of Education Review1998，17，3： | 1 |
| 17 | Rela-tionship between allergic rhinitis,disturbed cognitive functions and psychological well being显示文摘 | KREMER B DEN HARTOG H M JOLLES J | 2002 | Clin Exp Allergy2002，32，： | 1 |
| 18 | Linking Measured Risk Aversion to Individual Charac teristics显示文摘 | HARTOG J FERRER-I-CARBONELL A JONKER N | 2002 | Kyklos2002，55，1： | 1 |
| 19 | A potential role for regulatory T-cells in the amelioration of DSS induced colitis by dietary non-digestible polysaccharides显示文摘 | Hartog A Belle FN Bastiaans J | 2015 | J Nutr Biochem2015，26，3： | 1 |
| 20 | The Arabidopsis somatic embryogenesis receptor kinase 1 gene is expressed in developing ovules and embryos and enhances embryogenic competence in culture显示文摘 | Hecht V Vielle-Calzada J P Hartog M V | 2001 | Plant Physiol2001，127，： | 1 |
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