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| 1 | Diagnosis of focal liver lesions with deep learning-based multichannel analysis of hepatocyte-specific contrast-enhanced magnetic resonance imaging显示文摘BACKGROUND The nature of input data is an essential factor when training neural networks.Research concerning magnetic resonance imaging(MRI)-based diagnosis of liver tumors using deep learning has been rapidly advancing.Still,evidence to support the utilization of multi-dimensional and multi-parametric image data is lacking.Due to higher information content,three-dimensional input should presumably result in higher classification precision.Also,the differentiation between focal liver lesions(FLLs)can only be plausible with simultaneous analysis of multisequence MRI images.AIM To compare diagnostic efficiency of two-dimensional(2D)and three-dimensional(3D)-densely connected convolutional neural networks(DenseNet)for FLLs on multi-sequence MRI.METHODS We retrospectively collected T2-weighted,gadoxetate disodium-enhanced arterial phase,portal venous phase,and hepatobiliary phase MRI scans from patients with focal nodular hyperplasia(FNH),hepatocellular carcinomas(HCC)or liver metastases(MET).Our search identified 71 FNH,69 HCC and 76 MET.After volume registration,the same three most representative axial slices from all sequences were combined into four-channel images to train the 2D-DenseNet264 network.Identical bounding boxes were selected on all scans and stacked into 4D volumes to train the 3D-DenseNet264 model.The test set consisted of 10-10-10 tumors.The performance of the models was compared using area under the receiver operating characteristic curve(AUROC),specificity,sensitivity,positive predictive values(PPV),negative predictive values(NPV),and f1 scores.RESULTS The average AUC value of the 2D model(0.98)was slightly higher than that of the 3D model(0.94).Mean PPV,sensitivity,NPV,specificity and f1 scores(0.94,0.93,0.97,0.97,and 0.93)of the 2D model were also superior to metrics of the 3D model(0.84,0.83,0.92,0.92,and 0.83).The classification metrics of FNH were 0.91,1.00,1.00,0.95,and 0.95 using the 2D and 0.90,0.90,0.95,0.95,and 0.90 using the 3D models.The 2D and 3D networks'performance in the diagnosis of HCC were 1.00,0.80,0.91,1.00,and 0.89 and 0.88,0.70,0.86,0.95,and 0.78,respectively;while the evaluation of MET lesions resulted in 0.91,1.00,1.00,0.95,and 0.95 and 0.75,0.90,0.94,0.85,and 0.82 using the 2D and 3D networks,respectively.CONCLUSION Both 2D and 3D-DenseNets can differentiate FNH,HCC and MET with good accuracy when trained on hepatocyte-specific contrast-enhanced multi-sequence MRI volumes. | Róbert Stollmayer Bettina K Budai Ambrus Tóth IldikóKalina Erika Hartmann Péter Szoldán Viktor Bérczi Pál Maurovich-Horvat Pál N Kaposi | 2021 | World Journal of Gastroenterology2021，27，35： | 6 |
| 2 | Different effects of a CD14 gene polymorphism on disease outcome in patients with alcoholic liver disease and chronic hepatitis C infection显示文摘AIM: Clinical and experimental data suggest that gut-derived endotoxins are an important pathogenic factors for progression of chronic liver disease. Recently, a C-T (-159)polymorphism in the promoter region of the CD14 gene was detected and found to confer increased CD14 expression and to be associated with advanced alcoholic liver damage. Here, we investigated this polymorphism in patients with less advanced alcoholic liver disease (ALD)and chronic hepatitis C virus (HCV) infection.METHODS: CD14 genotyping was performed by PCR-RFLP analysis in (a) 121 HCV patients, (b) 62 patients with alcohol-associated cirrhosis (Alc-Ci), (c) 118 individuals with heavy alcohol abuse without evidence of advanced liver damage (Alc-w/o Ci), and (d) 247 healthy controls.Furthermore, serum levels of soluble CD14 (sCD14) and transaminases were determined.RESULTS: The TT genotype was significantly more frequent in Alc-Ci compared to Alc-w/o Ci or controls (40.3% vs 23.7% or 24.0%, respectively). In Alc-w/o Ci,serum levels of transaminases did not differ significantly between patients with different CD14 genotypes. In HCV patients, TT-homozygotes had significantly higher sCD14 levels and sCD14 serum levels were significantly higher in patients with advanced fibrosis or cirrhosis. However,no association was found between CD14 genotypes and histological staging or grading.CONCLUSION: Considering serum transaminases as surrogate markers for alcoholic liver damage, the CD14 polymorphism seems to exhibit different effects during the course of ALD. Differences in genotype distribution between cirrhotic HCV patients and alcoholics and the known functional impact of this polymorphism on CD14 expression levels further indicate differences in the pathophysiological role of CD14 and CD14-mediated lipopolysaccharides signal transduction with regard to the stage as well as the type of the underlying liver disease. | C Meiler M Mühlbauer M Johann A Hartmann B Schnabl N Wodarz G Schmitz J Schlmerich C Hellerbrand | 2005 | World Journal of Gastroenterology2005，11，38： | 3 |
| 3 | A Hydro-code Material Model for Concrete显示文摘 | Hartmann T Pietzsch A Gebbeken N | 2010 | International Journal of Protective Structures2010，1，4： | 1 |
| 4 | Evidence for the identity of human scatter factor and human hepatocyte growth factor显示文摘 | Weider KM Arakaki N Hartmann G | 1991 | Proc Natl Acad Sci USA1991，88，： | 1 |
| 5 | A field technique for evaluating physical condition of deer显示文摘 | Kistner T P Trainer C E Hartmann N A | 1980 | Wildl Soc Bull1980，8，1： | 1 |
| 6 | Recombinant CD95-Fc (APG101) prevents graft-versus-host disease in mice without disabling antitumor cytotoxicity and T-cell functions显示文摘 | Hartmann N Messmann JJ Leith(a)user F | | 0，，： | 1 |
| 7 | Simulation and Analysis of Different Adiabatic Compressed Air Energy Storage Plant Configurations 显示文摘 | Hartmann N VShringer O Kruck C | 2012 | Applied Energy2012，93，： | 1 |
| 8 | A hydrocode material model for concrete 显示文摘 | HARTMANN T PIETZSCH A GEBBEKEN N | 2010 | International Journal of Protective Structures2010，1，： | 1 |
| 9 | DNA methylation markers predict outcome in node-positive,estrogen receptor-positive breast cancer with adjuvant anthracycline-based chemotherapy显示文摘 | Hartmann O Spyratos F Harbeck N | 2009 | Clin Cancer Res2009，15，1： | 1 |
| 10 | CXCR4 chemokine receptor and integrin signaling co-operate in mediating adhesion and chemoresistance in small cell lung cancer(SCLC) cells显示文摘 | Hartmann T N Burger J A Glodek A | 2005 | Oncogene2005，24，27： | 1 |
| 11 | Diversity of carbofuran-degrading soil bacteria and detection of plasmidencoded sequences homologous to the med gene显示文摘 | Parrkh N R Hartmann A Charnay M P | 1995 | FEMS Microbiol Ecol1995，17，： | 1 |
| 12 | Global CO-2consumption by chemical weathering:What is the contribution of highly active weathering regions?显示文摘 | Hartmann J Jansen N Dürr H H | 2009 | Global and Planetary Change2009，69，4： | 1 |
| 13 | Ecotoxicity of engineered nanoparticles to aquatic invertebrates: A brief review and recommendations for future toxicity testing 显示文摘 | Baun A Hartmann N Grieger K | 2008 | Ecotoxicology2008，17，5： | 1 |
| 14 | Anaerobic degrada- tion of decabromodiphenyl ether显示文摘 | Gerecke A C Hartmann P C Heeb N V | 2005 | Environmental Sci Technol2005，39，4： | 1 |
| 15 | Radiation channels close to a plasmonic nanowire visualized by back focal plane imaging 显示文摘 | HARTMANN N PIATKOWSKI D CIESIELSKI R | 2013 | ACS Nano2013，，10： | 1 |
| 16 | Anaerobic Degradation of Decabromodiphenyl Ether显示文摘 | Gerecke A C Hartmann P C Heeb N V | 2005 | Environ Sci Technol2005，39，4： | 1 |
| 17 | Evidence for the identity of human scatter factor and human hepatocyte growth factor 显示文摘 | Weidner KM Arakaki N Hartmann G | 1991 | Proc Natl Acad Sci USA1991，88，16： | 1 |
| 18 | Anaerobic degradation of deeabromodiphenyl ether 显示文摘 | Gerecke A C Hartmann P C Heeb N V | 2005 | Environmental Science and Technology2005，39，4： | 1 |
| 19 | The obligate intracellular parasite Toxoplasma gondii secretes a soluble phosphatidylserine decarboxylase 显示文摘 | Gupta N Hartmann A Lucius R | 2012 | J Biol Chem2012，287，22： | 1 |
| 20 | Expression of collagen type I and type II in consecutive stages of human osteoarthritis显示文摘 | Miosge N Hartmann M Maelicke C | 2004 | Histochem Cell Biol2004，122，3： | 1 |
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