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| 1 | 器官移植受体发生EBV阳性的皮肤黏膜溃疡:一种局限性惰性移植后淋巴组织增殖性疾病显示文摘Epstein-Barr 病毒( EBV )阳性的皮肤黏膜溃疡( EBV MCU)是在老人或医源性免疫受损患者中发生的一种B细胞淋巴组织增殖性疾病,尚未见发生于实体器官移植受者的报道。作者在70例EBV阳性移植后淋巴组织增殖性疾病( PTLD)患者中发现7例EBV阳性MCU。包括5例肾脏、1例心脏和1例肺脏移植,其中男性5例。患者中位年龄61岁,4例发生于口腔黏膜,3例发生于胃肠道。溃疡病变发生前患者接受免疫抑制治疗0.6-13年。溃疡由炎症细胞和多形性或单形性大细胞增生,破坏皮肤黏膜而形成。5例中可见Reed-Sternberg样细胞。所有病例CD20、CD30阳性,原位杂交EBER结果阳性。3例近期患者被诊断为EBV阳性MCU,4例患者前期被诊断为单形性大细胞PTLD(n=3)和多形性 PTLD ( n =1)。所有患者血液 EBV DNA 均阴性(〈1000拷贝数/ml),而在诊断或随访的44例移植患者中有35例发生系统性 PTLD ( P 〈0.001)。所有 EBV 阳性MCU患者通过减少免疫抑制剂用量(7/7),调整免疫抑制剂用量(2/7),和联用利妥昔单抗(3/7)等使皮损得到治愈。目前5例存活:其中4例身体健康,1例在等待肾移植手术;另2例分别在EBV阳性MCU治愈后的3年和5年死亡。未发现EBV阳性MCU复发或其他PTLD。 | Hart M Thakral B Yohe S 胡舜摘 余英豪 | 2014 | 临床与实验病理学杂志2014，30，12： | 5 |
| 2 | Indirect enzyme-linked immunosorbent assay for the mycotoxin zearalenone显示文摘 | Liu M T Ram B P Hart L P and Pestka J J | 1985 | Appl Environ Microbiol1985，50，2： | 1 |
| 3 | Synthesis ofdimethylcarbonate by vapor phase oxidative carbonylation of methanol over Cu-based catalysts显示文摘 | Hart M S Lee B G Ahn B S | 2001 | Journal of Molecular Catalysis2001，170，1： | 1 |
| 4 | Apramycin-resistant Escheriehia coli isolated from pigs and a stockman显示文摘 | Hunter J E B Bennett M Hart C A | 1994 | Epidemiol infect1994，112，： | 1 |
| 5 | Vibration analysis of circtdar Mindlin plates using the differential quadrature method显示文摘 | Liew K M Hart J B Xiao Z M | 1997 | Journal of Sound and Vibration1997，205，5： | 1 |
| 6 | External skeletal fixation of canine tibial osteotomies: Compression compared with no compression显示文摘 | Hart M B Wu J J Chao EYS | 1985 | J Bone Joint Surg(Am)1985，67，4： | 1 |
| 7 | Determination ofsugars in yogurt and microbiological media by high performance liquidchromatography during processing and subsequent storage显示文摘 | RICHMOND M L HARTE B R GRAY J I | 1987 | Journal ofDairy Science1987，70，6： | 1 |
| 8 | Ion microprobe analysis of oxygen,carbon and hydrogen isotope ratios显示文摘 | Graham C M Harte B | 1998 | SEG Reviews in Economic Geology1998，7，： | 1 |
| 9 | Microstructure and proper- ties of high chrome steel roller after laser surface melting 显示文摘 | Li M Y Wang Y Hart B | 2009 | Applied Surface Science2009，255，： | 1 |
| 10 | Apramycin-resistant Escheriehia coli isolated from pigs and a stockman显示文摘 | Hunter J E B Bennett M Hart C A | 1994 | Epidemiol infect1994，112，： | 1 |
| 11 | The placental transfer of propylthiouracil, methimazole and carbimazole 显示文摘 | MARCHANT B BROWNLIE B E HART D M | 1977 | Clin Endocrinol Metab1977，45，6： | 1 |
| 12 | The nitrogen cycle in the Broadbalk wheat experiment: 15N-labelled fertilizer residues in the soil and in the soil microbial biomass显示文摘 | Shen S M Hart B S Powlson D S | 1989 | Soil Biology and Biochemistry1989，21，4： | 1 |
| 13 | Ischemia - reperfusion decreases protein phosphorylation and p38 mitogen - activated protein kinase phosphorylation in rat lung transplants 显示文摘 | Sakiyama S dePerrot M Hart B Wadded TK Keshavjee S Liu M | 2003 | J Heart Lung Transplantation2003，22，： | 1 |
| 14 | Late Cretaceous anoxic events in the Brazilian continental margin显示文摘 | Mello M R Koutsoukos E A M Hart M B | 1990 | Organic Geochemistry1990，14，： | 1 |
| 15 | Separation ofcarbohydrates in dairy products by high performance liquidchromatography显示文摘 | RICHMOND M L BARFUSS D L HARTE B R | 1982 | Journal of Dairy Science1982，65，8： | 1 |
| 16 | Phosphorus Runoff From Agricultural Land and Direct Fertilizer Effects:A Review 显示文摘 | HART M R QUIN B F NGUYEN M L | 2004 | Jour- nal of Environmental Quality2004，33，6： | 1 |
| 17 | Tomato transcription factors Pti4,PtiS,and Pti6 activate defense responses when expressed in Arabidopsis显示文摘 | Gu Y Q Wildermuth M C ChaEravarthy S Loh Y T Yang C He X H Hart Y Martin G B | | 0，，： | 1 |
| 18 | HLA-Dq polymorphism and heteroplamay levels of the A3243G mitochondrial mutation in maternally inherited diabetes and deafness 显示文摘 | VANESSEN H E R ROEP B O HART L M etal | 2000 | Diabete Med2000，17，： | 1 |
| 19 | Modern seawateracidification:the response of foraminifera to high-CO2conditions in the Mediterranean Sea显示文摘 | Dias B B Hart M B Smart C W | 2010 | Journal of theGeological Society2010，167，： | 1 |
| 20 | Creating Sustainable Value显示文摘 | Hart S L Milstein M B | 2003 | Academy of Management Executive2003，17，2： | 1 |
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