|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Interaction of obesity and inflammatory bowel disease显示文摘Inflammatory bowel disease(IBD) is a chronic inflammatory condition of unknown etiology that is thought to result from a combination of genetic, immunologic and environmental factors. The incidence of IBD has been increasing in recent decades, especially in developing and developed nations, and this is hypothesized to be in part related to the change in dietary and lifestyle factors associated with modernization. The prevalence of obesity has risen in parallel with the rise in IBD, suggesting a possible shared environmental link between these two conditions. Studies have shown that obesity impacts disease development and response to therapy in patients with IBD and other autoimmune conditions. The observation that adipose tissue produces pro-inflammatory adipokines provides a potential mechanism for the observed epidemiologic links between obesity and IBD, and this has developed into an active area of investigative inquiry. Additionally, emerging evidence highlights a role for the intestinal microbiota in the development of both obesity and IBD, representing another potential mechanistic connection between the two conditions. In this review we discuss the epidemiology of obesity and IBD, possible pathophysiologic links, and the clinical impact of obesity on IBD disease course and implications for management. | Jason W Harper Timothy L Zisman | 2016 | World Journal of Gastroenterology2016，22，35： | 6 |
| 2 | The anaphase-promoting complex:It's not just for mitosis any more显示文摘 | Harper J W Burton J L Solomon M J | 2002 | Genes Dev2002，16，： | 2 |
| 3 | Bo-vine citrullinaemia-A clinical,pathological,biochemi-cal and genetic study显示文摘 | HEALY P J HARPER P A W DENNIS J A | 1990 | Aust Vet J1990，67，： | 1 |
| 4 | The p21CDK-interacting protein Gip1 is a potent inhibitor of G1cyclin-dependent kinases显示文摘 | Adami G R Wei N | 1993 | Cell1993，75，： | 1 |
| 5 | Innate inflammation and resolution in acute gout显示文摘 | Martin W J Harper J L | 2010 | Immunol Cell Biol2010，88，： | 1 |
| 6 | Cerebral cavernous malformations:nature history and prognosis after clinical deterioration with or without hemorrhage 显示文摘 | Poter PJ Willinsky PA Harper W | 1997 | J Neurosurg1997，87，2： | 1 |
| 7 | Extraction of rice bran protein concentrate and its application in bread显示文摘 | JIAMYANGYUEN S SRIJESDARUK V HARPER W J | 2005 | Songklanakarin Journal Science Technology2005，27，1： | 1 |
| 8 | Report of two planned interim analyses in a randomized muhicenter phase Ⅲ study comparing capcitabine with fluorouracil and oxaliplatin with cisplatin in patients with advanced oesophagogastric cancer receiving ECF 显示文摘 | Sumpler KA Harper W Cunningham D | 2005 | Br J Cancer2005，92，： | 1 |
| 9 | Nitrogen Cycling in a Wheat Crop:Soil,Plant,and Aerial Nitrogen Transport显示文摘 | HARPER L A SHARPE R R LANGDALE G W | 1987 | Agronomy Journal1987，79，6： | 1 |
| 10 | Expression profiling of gastric adenocarcinoma using cDNA array显示文摘 | El-Rifai W Frierson H F Harper J C | 2001 | IntJCancer2001，93，： | 1 |
| 11 | Modeling moral education:the basis for rehabilitation显示文摘 | Harper G W Shute R W | 1986 | J Correct Educat1986，37，2： | 1 |
| 12 | Sorption and Desorption of Perchlorate with Various Classes of Ion Exchangers:A Comparative Study显示文摘 | Xiong Z Zhao D Harper W F | 2007 | Industrial & Engineering Chemistry Research2007，46，26： | 1 |
| 13 | CDK2 encodes a 33-ku cyclinA-associated protein kinase and is expressed before CDC2 in the cell cycle 显示文摘 | BIOL N HARPER J W | 1992 | Proc Natl Acad Sci USA1992，89，： | 1 |
| 14 | Some factors affecting the heat in- activation of the milk lipase enzyme system显示文摘 | Harper W J Gould I A | 1959 | Proc 15th International Dairy Congress1959，，： | 1 |
| 15 | Network organization of the human autophagy system显示文摘 | Behrends C Sowa M E Gygi S P Harper J W | 2010 | Nature2010，466，7302： | 1 |
| 16 | Sensory Ratings of Commercial Plain Yogurts by Consumer and Descriptive Panels 显示文摘 | HARPER S J BARNES D L BODYFELT F W | 1991 | J Dairy Sci1991，74，： | 1 |
| 17 | Recept of two Protocal Planned Interin Analysis in a Randomized Multicenter Phase Ⅲ study comparing capecitabine with Fluorouracil and Oxaliplatin with Cisplatin in Patients with Advanced oesophagogastric Cancer Receiving ECF显示文摘 | Sumpter K Harper W Cuningham D | 2005 | Br J Cancer2005，92，： | 1 |
| 18 | Enhanced efficacy of a novel controlled release paclitaxel formulation ( PACLIMER delivery system ) for local-regional therapy of lung cancer tumor nodules in mice 显示文摘 | HARPER E DANG W LAPIDUS RG | 1999 | Clin Cancer Res1999，5，12： | 1 |
| 19 | WAF1/CIP1 is induced in p53 mediated G1 arrest and apoptosis 显示文摘 | El-Deiry W S Harper J W O ' Connor P M | 1994 | Cancer Res1994，54，： | 1 |
| 20 | An oriented peptide array library (OPAL) strategy to study protein-protein interactions显示文摘 | Rodriguez M Li S S Harper J W | 2004 | J Biol Chem2004，279，10： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员