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| 1 | Evolving concepts in bone infection: redefining “biofilm”,“acute vs. chronic osteomyelitis”, “the immune proteome” and “local antibiotic therapy”显示文摘Osteomyelitis is a devastating disease caused by microbial infection of bone. While the frequency of infection following elective orthopedic surgery is low, rates of reinfection are disturbingly high. Staphylococcus aureus is responsible for the majority of chronic osteomyelitis cases and is often considered to be incurable due to bacterial persistence deep within bone. Unfortunately, there is no consensus on clinical classifications of osteomyelitis and the ensuing treatment algorithm. Given the high patient morbidity,mortality, and economic burden caused by osteomyelitis, it is important to elucidate mechanisms of bone infection to inform novel strategies for prevention and curative treatment. Recent discoveries in this field have identified three distinct reservoirs of bacterial biofilm including: Staphylococcal abscess communities in the local soft tissue and bone marrow, glycocalyx formation on implant hardware and necrotic tissue, and colonization of the osteocyte-lacuno canalicular network(OLCN) of cortical bone. In contrast, S.aureus intracellular persistence in bone cells has not been substantiated in vivo, which challenges this mode of chronic osteomyelitis. There have also been major advances in our understanding of the immune proteome against S. aureus, from clinical studies of serum antibodies and media enriched for newly synthesized antibodies(MENSA), which may provide new opportunities for osteomyelitis diagnosis, prognosis, and vaccine development. Finally, novel therapies such as antimicrobial implant coatings and antibiotic impregnated 3D-printed scaffolds represent promising strategies for preventing and managing this devastating disease. Here, we review these recent advances and highlight translational opportunities towards a cure. | Elysia A. Masters Ryan P. Trombetta Karen L. de Mesy Bentley Brendan F Boyce Ann Lindley Gill Steven R. Gill Kohei Nishitani Masahiro Ishikawa Yugo Morita Hiromu Ito Sheila N. Bello-Irizarry Mark Ninomiya James D. Brodell Jr. Charles C. Lee Stephanie P. Hao Irvin Oh Chao Xie Hani A. Awad John L. Daiss John R. Owen Stephen L. Kates Edward M. Schwarz Gowrishankar Muthukrishnan | 2019 | Bone Research2019，7，3： | 19 |
| 2 | Evolution of transanal total mesorectal excision for rectal cancer:From top to bottom显示文摘The gold standard for curative treatment of locally advanced rectal cancer involves radical resection with a total mesorectal excision(TME). TME is the most effective treatment strategy to reduce local recurrence and improve survival outcomes regardless of the surgical platform used. However, there are associated morbidities, functional consequences, and quality of life(QoL) issues associated with TME; these risks must be considered during the modern-day multidisciplinary treatment for rectal cancer. This has led to the development of new surgical techniques to improve patient, oncologic, and QoL outcomes. In this work, we review the evolution of TME to the transanal total mesorectal excision(TaTME) through more traditional minimally invasive platforms. The review the development, safety and feasibility, proposed benefits and risks of the procedure, implementation and education models, and future direction for research and implementation of the TaTME in colorectal surgery. While satisfactory short-term results have been reported, the procedure is in its infancy, and long term outcomes and definitive results from controlled trials are pending.As evidence for safety and feasibility accumulates,structured training programs to standardize teaching,training, and safe expansion will aid the safe spread of the TaTME. | Sameh Hany Emile F Borja de Lacy Deborah Susan Keller Beatriz Martin-Perez Sadir Alrawi Antonio M Lacy Manish Chand | 2018 | World Journal of Gastrointestinal Surgery2018，10，3： | 18 |
| 3 | Review of the evidence for the management of co-morbid Tic disorders in children and adolescents with attention deficit hyperactivity disorder显示文摘Attention deficit hyperactivity disorder(ADHD) is the most common neurodevelopmental disorder in children and adolescents, with prevalence ranging between 5% and 12% in the developed countries. Tic disorders(TD) are common co-morbidities in paediatric ADHD patients with or without pharmacotherapy treatment. There has been conflicting evidence of the role of psychostimulants in either precipitating or exacerbating TDs in ADHD patients. We carried out a literature review relating to the management of TDs in children and adolescents with ADHD through a comprehensive search of MEDLINE, EMBASE, CINAHL and Cochrane databases. No quantitative synthesis(meta-analysis) was deemed appropriate. Metaanalysis of controlled trials does not support an association between new onset or worsening of tics and normal doses of psychostimulant use. Supratherapeutic doses of dextroamphetamine have been shown to exacerbate TD. Most tics are mild or moderate and respond to psychoeducation and behavioural management. Level A evidence support the use of alpha adrenergic agonists, including Clonidine and Guanfacine, reuptake noradrenenaline inhibitors(Atomoxetine) and stimulants(Methylphenidate and Dexamphetamines) for the treatment of Tics and comorbid ADHD. Priority should be given to the management of co-morbid Tourette's syndrome(TS) or severely disabling tics in children and adolescents with ADHD. Severe TDs may require antipsychotic treatment. Antipsychotics, especially Aripiprazole, are safe and effective treatment for TS or severe Tics, but they only moderately control the co-occurring ADHD symptomatology. Short vignettes of different common clinical scenarios are presented to help clinicians determine the most appropriate treatment to consider in each patient presenting with ADHD and co-morbid TDs. | Michael O Ogundele Hani F Ayyash | 2018 | World Journal of Clinical Pediatrics2018，7，1： | 10 |
| 4 | Exposing Digital Forgeries in Interlaced and De-Interlaced Video显示文摘 | WEIHONG W HANY F | 2007 | IEEE Transactions on Information Forensics and Security2007，2，03： | 1 |
| 5 | Integrated PET/CT for the assessment of coronary artery disease:A feasibility study显示文摘 | Namdar M Hany T F Koepfli P | 2005 | J Nucl Med2005，46，： | 1 |
| 6 | Staging of non-small cell lung cancer with integrated positron emission tomography and computed tomography显示文摘 | LARDINOIS D WEDER W HANY T F | 2003 | N Engl J Med2003，348，25： | 1 |
| 7 | Time-resolved three-dimensional contrast-enhanced MR angiography of the peripheral vesscls显示文摘 | Wieben O Grist T M Hany T F | 2002 | Radiology2002，225，5： | 1 |
| 8 | PET diagnostic accuracy improvement with in line PET-CT system: initial results显示文摘 | HANY T F STEINERT H C GOERRES G W | 2002 | Radiology2002，225，2： | 1 |
| 9 | Flexural-torsional buckling of pultruded fiber reinforced plastic composite I-beams: experimental and analytical evaluations 显示文摘 | Davalos Jufio F Qiao Pizhong Salim Hani A | 1997 | Composite Structures1997，38，1： | 1 |
| 10 | Segmentation and classification of whiteb lood cells显示文摘 | Bikhet Sawsan F Darwish Ahmed M Tolba Hany A | 2000 | IEEE Transactions on Medical Imageing2000，19，3： | 1 |
| 11 | The relation between hepatitis C virus and coronary heart disease显示文摘 | Amr Hany Metwally Mohamed-Adel F Elgamal | 2014 | Medical Hypotheses2014，82，4： | 1 |
| 12 | Automated fluorescence-based screening for mutation by SSCP:use of universal M13 dye primers for labeling and detection显示文摘 | Boutin P Hani E H Vasseur F | 1997 | Biotechniques1997，23，3： | 1 |
| 13 | Tuberculosis of the lymph glands of the neck : a limited role for surgery显示文摘 | AMMARI F F BANI HANI A H GHARIEBEH K I | 2003 | Otolaryngol Head Neck Surg2003，128，4： | 1 |
| 14 | A Simplified Technique for Shakedown Limit Load Determination显示文摘 | Hany F Abdalla Mohammad M Megahed Maher Y A Younan | 2007 | Nuclear Engineering and De- sign2007，237，1213： | 1 |
| 15 | Fly ash-based geopolymer for Pb removal from aqueous solution 显示文摘 | AI-Zboon K AI-Harahsheh M S Hani F B | 2011 | Journal of Hazardous Materials2011，188，13： | 1 |
| 16 | On low-frequency electic powergeneration with PZT ceramics显示文摘 | STEPHEN R P SHANE F HANI H | 2005 | IEEE/ASME Transactions on Mechatronies2005，10，2： | 1 |
| 17 | Exposing digital forgeries from JPEG ghosts显示文摘 | HANY F | 2009 | IEEE Transactions on Information Forensics and Security Archive2009，4，1： | 1 |
| 18 | Exposing Digital Forgeries in Interlaced and De-Interlaced Video显示文摘 | WEIHONG W HANY F | 2007 | IEEE Transactions on Information Forensics and Security2007，2，3： | 1 |
| 19 | On Low-frequency electric power generation with PZT ceramics显示文摘 | Stephen R Shane F Hani H | 2005 | IEEE/ASME Transactions on Mechatronics2005，10，2： | 1 |
| 20 | Plevic and lower extremity arterial imaging diagnostic performance of three-dimen- sional contrast-enhanced MR angiography显示文摘 | Ruehm S G Hany T F Pfammaatter T | 2000 | AJR2000，174，4： | 1 |
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